The structural parameters for antimicrobial activity, human epithelial cell cytotoxicity and killing mechanism of synthetic monomer and dimer analogues derived from hBD3 C-terminal region

Amino Acids

Volumn 40, Issue 1, 2011, Pages 123-133

  Zhou, L ^a,b   Liu, S P ^a   Chen, L Y ^a   Li, J ^a,b   Ong, L B ^c   Guo, L ^c   Wohland, T ^c   Tang, C C ^d   Lakshminarayanan, R ^a   Mavinahalli, J ^e   Verma, C ^e   Beuerman, R W ^a,b,f  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d SINGAPORE GENERAL HOSPITAL   (Singapore)

^e BIOINFORMATICS INSTITUTE   (Singapore)

^f DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Antimicrobial peptides (AMPs); Covalent dimerization; Cytotoxicity; Fluorescence correlation spectroscopy (FCS); Human defensin 3 (hBD 3)

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; BETA DEFENSIN 3; DIMER; GLYCEROPHOSPHOLIPID; MONOMER; RHODAMINE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; CYTOTOXICITY TEST; DIMERIZATION; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG SYNTHESIS; EPITHELIUM CELL; FLUORESCENCE CORRELATION SPECTROSCOPY; HUMAN; HUMAN CELL; HYDROPHOBICITY; MAMMAL CELL; MOLECULAR DYNAMICS; NONHUMAN; PEPTIDE SYNTHESIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BETA-DEFENSINS; CELL LINE; CYTOTOXINS; DIMERIZATION; EPITHELIAL CELLS; GRAM-NEGATIVE BACTERIA; HUMANS; MOLECULAR STRUCTURE;

BACTERIA (MICROORGANISMS); MAMMALIA; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 78751585357     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0565-8     Document Type: Article

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