NMR structures and interactions of temporin-1Tl and temporin-1Tb with lipopolysaccharide micelles: Mechanistic insights into outer membrane permeabilization and synergistic activity

Journal of Biological Chemistry

Volumn 286, Issue 27, 2011, Pages 24394-24406

  Bhunia, Anirban ^a   Saravanan, Rathi ^a   Mohanram, Harini ^a   Mangoni, Maria L ^b   Bhattacharjya, Surajit ^a,c  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c 60 Nanyang Dr ^*  (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL PEPTIDE; CONFORMATIONAL CHANGE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GAIN INSIGHT; GRAM-NEGATIVE BACTERIA; HELICAL STRUCTURES; LIPOPOLYSACCHARIDES; MODE OF ACTION; NMR STRUCTURES; OUTER MEMBRANE; SATURATION TRANSFER DIFFERENCE NMR; STRUCTURAL INSIGHTS; SYNERGISTIC ACTIVITY; SYNERGISTIC MECHANISM; TEMPORINS;

AROMATIC COMPOUNDS; AROMATIZATION; BACTERIA; BACTERIOLOGY; ENERGY TRANSFER; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; MICELLES; NUCLEAR MAGNETIC RESONANCE; OLIGOMERIZATION; OLIGOMERS; PEPTIDES;

DRUG INTERACTIONS;

LIPOPOLYSACCHARIDE; POLYPEPTIDE ANTIBIOTIC AGENT; TEMPORIN 1TB; TEMPORIN 1TL; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; FLUORESCENCE SPECTROSCOPY; FROG; GRAM NEGATIVE BACTERIUM; MEMBRANE PERMEABILITY; MICELLE; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMPHIBIAN PROTEINS; ANIMALS; ANTI-INFECTIVE AGENTS; CELL MEMBRANE PERMEABILITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GRAM-NEGATIVE BACTERIA; HUMANS; LIPOPOLYSACCHARIDES; MICELLES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RANIDAE;

ANURA; NEGIBACTERIA;

EID: 79959903251     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.189662     Document Type: Article

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