An antioxidant Trolox restores decreased oral absorption of cyclosporine A after liver ischemia-reperfusion through distinct mechanisms between CYP3A and P-glycoprotein in the small intestine

European Journal of Pharmacology

Volumn 690, Issue 1-3, 2012, Pages 192-201

  Ikemura, Kenji ^a,c   Inoue, Koichi ^c   Mizutani, Hideki ^c   Oka, Hisao ^c   Iwamoto, Takuya ^a,b   Okuda, Masahiro ^a,b  

^a MIE UNIVERSITY   (Japan)

^b MIE UNIVERSITY HOSPITAL   (Japan)

^c KINJO GAKUIN UNIVERSITY   (Japan)

Author keywords

Cyclosporine A; CYP3A; Liver ischemia reperfusion; P glycoprotein; Small intestine; Trolox

Indexed keywords

CYCLOSPORIN A; CYTOCHROME P450 3A; GLUTATHIONE; GLYCOPROTEIN P; LITHOCHOLIC ACID; MALONALDEHYDE; MESSENGER RNA; TROLOX C;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYP3A GENE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; GENETIC TRANSCRIPTION; LIVER ISCHEMIA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SINGLE DRUG DOSE; SMALL INTESTINE ABSORPTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; BILE ACIDS AND SALTS; CHROMANS; CYCLOSPORINE; CYTOCHROME P-450 CYP3A; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; INTESTINAL ABSORPTION; INTESTINE, SMALL; LIVER; MALE; MALONDIALDEHYDE; P-GLYCOPROTEIN; RATS; RATS, WISTAR; REPERFUSION INJURY; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 84864462029     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.06.031     Document Type: Article

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