Structural damage to proteins caused by free radicals: Asessment, protection by antioxidants, and influence of protein binding

Biochemical Pharmacology

Volumn 61, Issue 10, 2001, Pages 1237-1242

  Salvi, Aline ^a   Carrupt, Pierre Alain ^a   Tillement, Jean Paul ^b   Testa, Bernard ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

Author keywords

Antioxidants; Capillary electrophoresis; Free radicals; Human serum albumin; Protein binding; Protein oxidation

Indexed keywords

ANTIOXIDANT; BETA LACTOGLOBULIN; CHLOROGENIC ACID; FREE RADICAL; HUMAN SERUM ALBUMIN; LYSOZYME; MELATONIN; QUERCETIN; TROLOX C;

ANTIOXIDANT ACTIVITY; ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; DRUG EFFECT; DRUG POTENTIATION; DRUG PROTEIN BINDING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE;

AMIDINES; ANIMALS; ANTIOXIDANTS; CHLOROGENIC ACID; CHROMANS; DRUG INTERACTIONS; FREE RADICALS; LACTOGLOBULINS; MELATONIN; MURAMIDASE; OXIDATION-REDUCTION; PROTECTIVE AGENTS; PROTEIN BINDING; QUERCETIN;

EID: 0035874009     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00607-4     Document Type: Article

References (18)

1. Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells
2. Metal-catalyzed oxidation of human serum albumin: Conformational and functional changes
3. Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans
4. Participation of oxygen-free radicals in the oxido-reduction of proteins
5. Histidine and proline are important sites of free radical damage to proteins
6. Development of a capillary electrophoresis method to monitor protein oxidation and antioxidant protection
7. Damage to biological tissues induced by radical initiator 2,2′-azobis(2-amidinopropane) dihydrochloride and its inhibition by chain-breaking antioxidants
8. Oxidation of lipids. XII. Inhibition of oxidation of soybean phosphatidylcholine and methyl linoleate in aqueous dispersions by uric acid
9. DNA breaking activity of the carbon-centered radical generated from 2,2′-azobis(2-amidinopropane) hydrochloride (AAPH)
10. The pH dependence of lipid peroxidation using water-soluble azo initiators
11. 3+
12. Antioxidant potential of anaerobic human plasma: Role of serum albumin and thiols as scavengers of carbon radicals
13. Electrochemical behaviour and antioxidant activity of some natural polyphenols
14. Antioxidant and iron-chelation activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures
15. Structural aspects of antioxidant activity of flavonoids
16. Active oxygen generation by flavonoids
17. Free radical-induced fragmentation of proteins by quercetin
18. Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships