Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2591-2596

  Madhukar, Mamta ^a   Sawraj, Shruti ^a   Sharma, Pritam Dev ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

4 Biphenylacetic acid; Cyclooxygenase; Mutual prodrug; Reactive oxygen species

Indexed keywords

ANALGESIC AGENT; ANTIULCER AGENT; FELBINAC; NONSTEROID ANTIINFLAMMATORY AGENT; PRODRUG; QUERCETIN 5,7,3' 4' TETRAMETHYL ETHER; QUERCETIN DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIULCER ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HYDROLYSIS; LIPOPHILICITY; MALE; NONHUMAN; PAIN; PARTITION COEFFICIENT; PAW EDEMA; PHYSICAL CHEMISTRY; RAT; STOMACH ULCER; ULCEROGENESIS;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG DESIGN; DRUG STABILITY; DRUG TOXICITY; EDEMA; ENZYMES; GASTROINTESTINAL TRACT; HUMANS; HYDROLYSIS; MALE; MICE; PHENYLACETATES; PRODRUGS; QUERCETIN; RATS; SOLUBILITY; ULCER;

EID: 77950859504     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.047     Document Type: Article

References (30)

1. Gibson T. Br. J. Rheumatol. 27 (1988) 87-90
2. Vane J.R., and Botting R.M. Inflamm. Res. 47 (1998) S78-S87
3. Vane J.R. Nat. New Biol. 231 (1971) 232-235
4. Hla T., and Neilson K. Proc. Natl. Acad. Sci. USA 89 (1992) 7384-7388
5. Xie W., Chipman J.G., Robertson D.L., Erikson R.L., and Simmons D.L. Proc. Natl. Acad. Sci. USA 88 (1991) 2692-2696
6. Mc Carthy M.D. Gastroenterology 96 (1989) 662-674
7. Warner T.D., Giuliano F., Vojnovic I., Bukada A., Mitchell J.A., and Vane J.R. Proc. Natl. Acad. Sci. USA 96 (1999) 7563-7568
8. Wolfe M.M., Lichtenstein D.R., and Singh G. N. Engl. J. Med. 340 (1999) 1888-1899
9. Hawkey C.J. Lancet 353 (1999) 307-314
10. Xie W., Robertson D.L., and Simmons D.L. Drug Dev. Res. 25 (1992) 249-265
11. Dogne J.M., Supuran C.T., and Pratico D. J. Med. Chem. 48 (2005) 2251-2257
12. Schnitzer T.J. J. Am. Med. 110 (2001) 46-49
13. Bandyopadhyay U., Das D., and Banerjee R.K. Curr. Sci. 77 (1999) 658-665
14. Hassan A., Martin E., and Puig-Parellada P. Methods Find. Exp. Clin. Pharmacol. 20 (1998) 849-854
15. Jimenez M.J., and Alcaraz M.J. Fitoterapia 59 (1988) 25-38
16. Repetto M.G., and Llesuy S.F. Brazillian J. Med. Biol. Res. 35 (2002) 523-534
17. Singh G., and Sharma P.D. Indian J. Pharm. Sci. 56 (1994) 69-79
18. Bhosle D., Bharambe S., Garrola N., and Dhaneshwar S.S. Indian J. Pharma. Sci. 68 (2006) 286-294
19. Leppanen J., Huuskonen J., Nevalainen T., Gynther J., Taipale H., and Jarvinen T. J. Med. Chem. 45 (2002) 1379-1382
20. Sharma P.D., Kaur G., Kansal S., and Chandrian S.K. Indian J. Chem. 43B (2004) 2159-2164
21. Martin M.J., La-casa C., Alarcon-de-la-Lastra C., Cabeza J., Villegas J., and Motilva Y. Z. Naturforsch [C] 53 (1998) 82-88
22. Cotelle N. Curr. Top. Med. Chem. 1 (2001) 569-590
23. Yalkowsky S.H., and Morzowich W. In: Ariens E.J. (Ed). Drug Design (1980), Academic, New York 121-185
24. Hairsine P. Lab. Practice 38 (1989) 73-75
25. In: Yalkowsky S.H., Morzowich W., and Banerjee S. (Eds). Aqueous Solubility - Methods of Estimation for Organic Compounds (1992), Marcel Dekker, New York
26. In: Streng W.H. (Ed). Characterization of Compounds in Solution - Theory and Practice (2001), Kluwer Academic Plenum, New York
27. Wadhwa L.K., and Sharma P.D. Int. J. Pharm. 118 (1995) 31-39
28. Winter C.A., Risley G.A., and Nuss G.W. Proc. Soc. Exp. Biol. Med 3 (1962) 544-547
29. Cioli V., Putzolu S., Rossi V., Barcellona S.P., and Corradino C. Toxicol. Appl. Pharmacol. 50 (1979) 283-289
30. Koster R., Anderson M., and De Beer E.J. Fed. Proc. 18 (1959) 412