Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system

Biochemical Journal

Volumn 382, Issue 1, 2004, Pages 43-50

  Hamaguchi, Hidenori ^a   Fujimoto, Katsumi ^a   Kawamoto, Takeshi ^a   Noshiro, Mitsuhide ^a   Maemura, Koji ^b   Takeda, Norihiko ^b   Nagai, Ryozo ^b   Furukawa, Masae ^a   Honma, Sato ^c   Honma, Ken Ichi ^c   Kurihara, Hidemi ^a   Kato, Yukio ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Basic helix loop helix transcription factor; Circadian rhythm; Clock; Dec2; Negative feedback loop

Indexed keywords

CIRCADIAN REGULATION; GENE EXPRESSION; MOLECULAR CLOCK SYSTEMS;

BIOASSAY; DIMERS; GELS; GENES; PROTEINS;

BIOCHEMISTRY;

HELIX LOOP HELIX PROTEIN; LUCIFERASE; MESSENGER RNA; PROTEIN DEC2; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; EMBRYO; ENZYME ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; MOLECULAR CLOCK; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM;

5' FLANKING REGION; ADENOVIRIDAE; AMINO ACID SEQUENCE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL CLOCKS; CELL LINE; E-BOX ELEMENTS; ENDOTHELIAL CELLS; FEEDBACK, BIOCHEMICAL; FLAVOPROTEINS; GENE EXPRESSION REGULATION; HELIX-LOOP-HELIX MOTIFS; HOMEODOMAIN PROTEINS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; UMBILICAL VEINS;

ANIMALIA; MAMMALIA;

EID: 4344619671     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031760     Document Type: Article

References (39)

1. Allada, R., Emery, P., Takahashi, J. S. and Rosbash, M. (2001) Stopping time: the genetics of fly and mouse circadian clocks. Annu. Rev. Neurosci. 24, 1091-1119
2. Reppert, S. M. and Weaver, D. R. (2002) Coordination of circadian timing in mammals. Nature (London) 418, 935-941
3. Roenneberg, T. and Merrow, M. (2003) The network of time: understanding the molecular circadian system. Curr. Biol. 13, R198-R207
4. Dunlap, J. C. (1999) Molecular bases for circadian clocks. Cell 96, 271-290
5. Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der Horst, G. T., Hastings, M. H. and Reppert, S. M. (2000) Interacting molecular loops in the mammalian circadian clock. Science 288, 1013-1019
6. Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S. and Weitz, C. J. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280, 1564-1569
7. Hogenesch, J. B., Gu, Y. Z., Jain, S. and Bradfield, C. A. (1998) The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. U.S.A. 95, 5474-5479
8. Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H. and Reppert, S. M. (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98, 193-205
9. Preitner, N., Damiola, F., Lopez-Molina, L., Zakany, J., Duboule, D., Albrecht, U. and Schibler, U. (2002) The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110, 251-260
10. Ueda, H. R., Chen, W., Adachi, A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S. et al. (2002) A transcription factor response element for gene expression during circadian night. Nature (London) 418, 534-539
11. Boudjelal, M., Taneja, R., Matsubara, S., Bouillet, P., Dolle, P. and Chambon, P. (1997) Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. Genes Dev. 11, 2052-2065
12. Rossner, M. J., Dorr, J., Gass, P., Schwab, M. H. and Nave, K. A. (1997) SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Mol. Cell. Neurosci. 9, 460-475
13. Shen, M., Kawamoto, T., Yan, W., Nakamasu, K., Tamagami, M., Koyano, Y., Noshiro, M. and Kato, Y. (1997) Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. Biochem. Biophys. Res. Commun. 236, 294-298
14. Fujimoto, K., Shen, M., Noshiro, M., Matsubara, K., Shingu, S., Honda, K., Yoshida, E., Suardita, K., Matsuda, Y. and Kato, Y. (2001) Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Biochem. Biophys. Res. Commun. 280, 164-171
15. Honma, S., Kawamoto, T., Takagi, Y., Fujimoto, K., Sato, F., Noshiro, M., Kato, Y. and Honma, K. (2002) Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature (London) 419, 841-844
16. Alvarez, J. D. and Sehgal, A. (2002) Circadian rhythms: finer clock control. Nature (London) 419, 798-799
17. Jin, X., Shearman, L. P., Weaver, D. R., Zylka, M. J., de Vries, G. J. and Reppert, S. M. (1999) A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell 96, 57-68
18. Shearman, L. P., Jin, X., Lee, C., Reppert, S. M. and Weaver, D. R. (2000) Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol. Cell. Biol. 20, 6269-6275
19. Yamaguchi, S., Mitsui, S., Yan, L., Yagita, K., Miyake, S. and Okamura, H. (2000) Role of DBP in the circadian oscillatory mechanism. Mol. Cell. Biol. 20, 4773-4781
20. Maemura, K., Hsieh, C. M., Jain, M. K., Fukumoto, S., Layne, M. D., Liu, Y., Kourembanas, S., Yet, S. F., Perrella, M. A. and Lee, M. E. (1999) Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. J. Biol. Chem. 274, 31565-31570
21. Hida, A., Koike, N., Hirose, M., Hattori, M., Sakaki, Y. and Tei, H. (2000) The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription. Genomics 65, 224-233
22. Maemura, K., de la Monte, S. M., Chin, M. T., Layne, M. D., Hsieh, C. M., Yet, S. F., Perrella, M. A. and Lee, M. E. (2000) CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J. Biol. Chem. 275, 36847-36851
23. Suardita, K., Fujimoto, K., Oda, R., Shimazu, A., Miyazaki, K., Kawamoto, T. and Kato, Y. (2002) Effects of overexpression of membrane-bound transferrin-like protein (MTf) on chondrogenic differentiation in vitro. J. Biol. Chem. 277, 48579-48586
24. Vitaterna, M. H., King, D. P., Chang, A. M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W. and Takahashi, J. S. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264, 719-725
25. Sun, H. and Taneja, R. (2000) Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms. Proc. Natl. Acad. Sci. U.S.A. 97, 4058-4063
26. St-Pierre, B., Flock, G., Zacksenhaus, E. and Egan, S. E. (2002) Stra13 homodimers repress transcription through class B E-box elements. J. Biol. Chem. 277, 46544-46551
27. Garriga-Canut, M., Roopra, A. and Buckley, N. J. (2001) The basic helix-loop-helix protein, sharp-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism. J. Biol. Chem. 276, 14821-14828
28. Butler, M. P., Honma, S., Fukumoto, T., Kawamoto, T., Fujimoto, K., Noshiro, M., Kato, Y. and Honma, K. (2004) Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of clock mutant mice. J. Biol. Rhythms 19, 126-134
29. Schoenhard, J. A., Eren, M., Johnson, C. H. and Vaughan, D. E. (2002) Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization. Am. J. Physiol. Cell Physiol. 283, C103-C114
30. Li, Y., Xie, M., Song, X., Gragen, S., Sachdeva, K., Wan, Y. and Yan, B. (2003) DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J. Biol. Chem. 278, 16899-16907
31. Kawamoto, T., Noshiro, M., Sato, F., Maemura, K., Takeda, N., Nagai, R., Iwata, T., Fujimoto, K., Furukawa, M., Miyazaki, K. et al. (2004) A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem. Biophys. Res. Commun. 313, 117-124
32. Azmi, S., Sun, H., Ozog, A. and Taneja, R. (2003) mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. J. Biol. Chem. 278, 20098-20109
33. Grechez-Cassiau, A., Panda, S., Lacoche, S., Teboul, M., Azmi, S., Laudet, V., Hogenesch, J. B., Taneja, R. and Delaunay, F. (2004) The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. J. Biol. Chem. 279, 1141-1150
34. Noshiro, M., Kawamoto, T., Furukawa, M., Fujimoto, K., Yoshida, Y., Sasabe, E., Tsutsumi, S., Hamada, T., Honma, S., Honma, K. and Kato, Y. (2004) Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP. Genes Cells 9, 317-329
35. Li, Y., Zhang, H., Xie, M., Hu, M., Ge, S., Yang, D., Wan, Y. and Yan, B. (2002) Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. Biochem. J. 367, 413-422
36. Shen, M., Kawamoto, T., Teramoto, M., Makihira, S., Fujimoto, K., Yan, W., Noshiro, M. and Kato, Y. (2001) Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/ Sharp2 in response to the cyclic adenosine monophosphate pathway. Eur. J. Cell Biol. 80, 329-334
37. Shen, M., Yoshida, E., Yan, W., Kawamoto, T., Suardita, K., Koyano, Y., Fujimoto, K., Noshiro, M. and Kato, Y. (2002) Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. J. Biol. Chem. 277, 50112-50120
38. Sun, H., Lu, B., Li, R. Q., Flavell, R. A. and Taneja, R. (2001) Defective T cell activation and autoimmune disorder in Stra13-deficient mice. Nat. Immunol. 2, 1040-1047
39. Fu, L., Pelicano, H., Liu, J., Huang, P. and Lee, C. (2002) The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111, 41-50