A novel C(28)-hydroxylated lupeolic acid suppresses the biosynthesis of eicosanoids through inhibition of cytosolic phospholipase A 2

Biochemical Pharmacology

Volumn 84, Issue 5, 2012, Pages 681-691

  Verhoff, Moritz ^a   Seitz, Stefanie ^b   Northoff, Hinnak ^c   Jauch, Johann ^b   Schaible, Anja M ^d   Werz, Oliver ^d  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Arachidonic acid; Cytosolic phospholipase A 2; Eicosanoids; Inflammation; Lupeolic acid; Triterpenes

Indexed keywords

3ALPHA ACETOXY 28 HYDROXYLUP 20 (29) EN 4BETA OIC ACID; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CYTOSOLIC PHOSPHOLIPASE A2; ICOSANOID; LUPEOLIC ACID; PENTACYCLIC TRITERPENE; PHOSPHOLIPID; PROSTAGLANDIN SYNTHASE; RESIN; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BOSWELLIA; BOSWELLIA CARTERII; CELL FREE SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; HYDROXYLATION; LIPID HYDROLYSIS; MONOCYTE; NEUTROPHIL; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION;

ARACHIDONIC ACID; CELLS, CULTURED; CYTOSOL; EICOSANOIDS; HUMANS; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MONOCYTES; NEUTROPHILS; PHOSPHOLIPASES A2; TRITERPENES;

EID: 84864397258     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.06.016     Document Type: Article

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