Effects of pyrrophenone, an inhibitor of group IVA phospholipase A 2, on eicosanoid and PAF biosynthesis in human neutrophils

British Journal of Pharmacology

Volumn 149, Issue 4, 2006, Pages 385-392

  Flamand, N ^a   Picard, S ^a   Lemieux, L ^a   Pouliot, M ^a   Bourgoin, S G ^a   Borgeat, P ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

cPLA 2 ; Leukocyte; Leukotriene; Lipid mediator; Neutrophil; Phospholipase A 2; Platelet activating factor; Prostaglandin; Pyrrolidine 1; Pyrrophenone

Indexed keywords

1 O ALKYLGLYCERO 3 PHOSPHORYLCHOLINE; ARACHIDONIC ACID; ARACHIDONIC ACID DERIVATIVE; ARACHIDONOYLTRIFLUOROMETHYL KETONE; CALCIMYCIN; FLUOROPHOSPHATE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; ICOSANOID; LEUKOTRIENE; METHYLARACHIDONOYLFLUOROPHOSPHONATE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE A2 IVA; PHOSPHOLIPASE D; PHOSPHONIC ACID DERIVATIVE; PROSTAGLANDIN E2; PYRROLE DERIVATIVE; PYRROPHENONE; THAPSIGARGIN; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; ICOSANOID METABOLISM; NEUTROPHIL; PRIORITY JOURNAL;

ARACHIDONIC ACIDS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSANOIDS; ENZYME INHIBITORS; GROUP IV PHOSPHOLIPASES A2; HUMANS; LEUKOTRIENES; NEUTROPHILS; PHOSPHOLIPASE D; PHOSPHOLIPASES A; PHOSPHOLIPASES A2; PHOSPHONIC ACIDS; PLATELET ACTIVATING FACTOR; PYRROLIDINES;

EID: 33750038908     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706879     Document Type: Article

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