Inhibitory effect of a potent and selective cytosolic phospholipase A 2α inhibitor RSC-3388 on skin inflammation in mice

Pharmacology

Volumn 81, Issue 4, 2008, Pages 301-311

  Yamamoto, Mina ^a   Haruna, Takayo ^a   Imura, Kinichi ^a   Hikita, Ichiro ^a   Furue, Yoko ^a   Higashino, Kenichi ^a   Gahara, Yoshinari ^a   Deguchi, Masashi ^a   Yasui, Kiyoshi ^a   Arimura, Akinori ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

2,4,6 Trinitro 1 chlorobenzene; Chemokine; Cytokine; Cytosolic phospholipase A2 ; Dermatophagoides farinae; Leukotriene; Prostaglandin

Indexed keywords

(E) N[(2,4) 4 [N(BIPHENYL 2 YLMETHYL)N 2 METHYLPROPYLAMINO] 1 [2 (2,4 DIFLUOROBENZOYL)BENZOYL]PYRROLIDIN 2 YL]METHYL 3 [4 (2,4 DIOXOTHIAZOLIDIN 5 YLIDENEMETHYL)PHENYL]ACRYLAMIDE; ANTIGEN; CHEMOKINE; CYTOKINE; ICOSANOID; INTERLEUKIN 1BETA; LEUKOTRIENE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PICRYL CHLORIDE; PIMEPROFEN; PROSTAGLANDIN; RSC 3388; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME INHIBITION; FEMALE; GENE EXPRESSION PROFILING; GENE TECHNOLOGY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OTITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SKIN INFLAMMATION;

ACRYLAMIDES; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; CHEMOKINE CCL3; CHEMOKINE CCL4; DERMATITIS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; GROUP IV PHOSPHOLIPASES A2; INTERLEUKIN-1BETA; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PICRYL CHLORIDE; RNA, MESSENGER; SKIN; THIAZOLIDINEDIONES;

EID: 43449089789     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000117816     Document Type: Article

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