Role of cytokines in ethanol-induced cytotoxicity in vitro in Hep G2 cells

Gastroenterology

Volumn 115, Issue 1, 1998, Pages 157-166

  Neuman, M G ^a   Shear, N H ^a   Bellentani, S ^a   Tiribelli, C ^a  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; BILE ACID; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; TAUROURSODEOXYCHOLIC ACID; TUMOR NECROSIS FACTOR ALPHA; URSODEOXYCHOLIC ACID;

ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DOSE TIME EFFECT RELATION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LIVER TOXICITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0031802169     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70377-4     Document Type: Article

References (52)

1. CJ McClain DA Cohen Increased tumor necrosis factor production by monocytes in alcoholic hepatitis Hepatology 9 1989 349 351
2. J Deviere J Content C Denys P Vandenbussehe L Schandene L Wybran E. Dupont Excessive in vitro bacterial lipopolysaccharide-induced production of monokines in cirrhosis Hepatology 11 1990 628 634
3. A Khoruts L Stanke CF McClain G Logan JI Allen Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients Hepatology 13 1991 267 276
4. N Sheron G Bird J Goka G Alexander IL Williiams Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis Clin Exp Immunol 84 1991 453 499
5. JV Castell T Geiger V Gross T Andus E Walter T Hirano T Kishimoto PCSO Heinrich Plasma clearance, organ distribution and target cells of interleukin 6/hepatocyte stimulating factor in the rat Eur J Biochem 177 1988 237 242
6. JS Fang BGLA T Nakamura GL Davis JYN Lau Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis Lancet 343 1994 820 823
7. A Mackiewicz H Schooltink PC Heinrich S. Rose-John Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins J Immunol 149 1992 2021 2027
8. AM Healy TD Gelehrter Introduction of plasminogen activator inhibitor-1 in Hep G2 human hepatoma cells by mediators of the acute phase response J Biol Chem 269 1994 19095 19100
9. H Baumann C Richards J. Gauldie Interaction among hepatocytestimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (Hep G2) cells J Immunol 139 1987 4122 4128
10. N Kobsel G. Ramadori Human hepatoma cells synthesize and secrete lysozyme: modulation by cytokines Hepatology 19 1994 1182 1188
11. P Greenwel MJ Iraburu M Reyes-Romero N Meraz-Cruz E Casado JA Solis-Herrozo M. Rojkind Induction of an acute phase response in rats stimulates the expression of alpha 1(I) procollagen messenger ribonucleic acid in their livers. Possible role of interleukin-6 Lab Invest 72 1995 83 91
12. S Jayaraman CA Martin ME Dorf Enhancement of in vivo cell-mediated immune responses by their distinct cytokines J Immunol 144 1990 942 951
13. MG Neuman G Koren C. Tiribelli In vitro assessment of the ethanol-induced hepatotoxicity on Hep G2 cell line Biochem Biophys Res Commun 197 1993 932 941
14. MG Neuman RG Cameron NH Shear S Bellentani C. Tiribelli Effect of tauroursodeoxycholic acid and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line Gastroenterology 109 1995 555 563
15. RG Cameron MG Neuman NH Shear G Katz S Bellentani C. Tiribelli Modulation of liver-specific cellular response to ethanol in vitro in Hep G2 cells In Vitro Toxicol 12 1998 1 29
16. M Marselos SC Strom G. Michalopulus Effect of phenobarbital and 3 methyl-chloranthrene on aldehyde dehydrogenase activity in cultures of Hep G2 cells and normal human hepatocytes Chem Biol Interact 62 1987 75 88
17. JR Dawson DJ Adams CR Wolf Induction of drug metabolizing enzymes in human liver cell line Hep G2 FEBS Lett 183 1985 219 222
18. VM Castro M Soderstrom I Carlberg M Widersten A Platz B. Mannervik Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes Carcinogenesis 11 1990 1569 1576
19. NC Jaen Direct blood injection method for gas chromatographic determination of alcohols and other volatile compounds Clin Chem 17 1971 82 85
20. A Meisner ME Anderson Glutathione Annu Rev Biochem 52 1983 711 760
21. F. Tietze Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: application to mammalian blood and other tissues Anal Biochem 27 1969 502 522
22. M Dixon EC Webb Enzymes 3rd ed 1979 Academic New York 626 630
23. SR Kirstensen M. Horder Release and turnover of intracellular enzymes HA Homburger Clinical and analytical concepts in enzymology. 1983 College of American Pathologists Skokie, IL 1 13
24. GL Sottocasa B Kuilenstierna L Ernster L. Bergstrand An electron transport system associated with the outer membrane of liver mitochondria: a biochemical and morphological study Cell Biol 32 1967 415 438
25. AR Henderson Lactate dehydrogenase isoenzymes 3rd ed HU Berg-meyer J Bergmeyer M Grasse Methods of enzymatic analysis. 3 1983 Verlag Chemie Weinheim, Germany 138 155
26. A Belfield DM Goldberg Enzyme diversion applied to the kinetic estimation of glucose-6-phosphatase activity Life Sci 8 1969 129 135
27. WG Yasmineh JI Caspers A. Theologides Homogeneous Trinder-coupled assay for the determination of glucose-6-phosphatase activity in tissue extracts Clin Biochem 25 1992 109 114
28. H. Baumgarten A simple microplate assay for the determination of cellular protein J Immunol Methods 82 1985 25 37
29. P Chomczynski N. Sacchi Single step method of RNA isolation by acid guanidinium thiochianate-phenol-chloroform extraction Anal Biochem 162 1987 156 159
30. ES Kawasaki Amplification of RNA MA Innis DH Gelfand JJ Sninsky TJ White PCR protocols: a guide to methods and applications. 1989 Academic San Diego, CA
31. TR Mosmann Rapid colorimetric assay for cellular growth and survival. Application to proliferation and cytotoxicity assays J Immunol Methods 65 1983 55 63
32. TM Buttke JA McCubrey TC Owen Use of an aqueous tetrazolium/formazan assay to measure viability and proliferation of lymphokine dependent cell lines J Immunol Methods 15 1993 233 240
33. P Huang W. Plunkett A quantitative assay for fragmented DNA in apoptotic cells Anal Biochem 207 1992 163 167
34. CJ McClain D Hill J Schmidt AM Diehl Cytokines and alcoholic liver disease Semin Liver Dis 13 1993 170 182
35. ME Felver E Mezey M McGuire MC Mitchell F Herlong GA Veech ILL Veech Plasma tumor necrosis factor-α predicts long term survival in severe alcoholic hepatitis Alcohol Clin Exp Res 14 1990 255 259
36. GLA Bird N Sheron AKJ Goka GS Alexander RS Williams Increased plasma tumor necrosis factor in severe alcoholic hepatitis Ann Intern Med 112 1990 917 920
37. P Akerman P Cote SQ Yang P Akerman P Cote SQ Yang C McClain S Nelson GJ Bagby AM Diehl Antibodies to tumor necrosis factor alpha inhibit induction of hepatocyte and non-parenchymal cell proliferation after partial hepatectomy AmJ Physiol 263 1992 G579 G585
38. ME Ostenson DL Thiele PE Lipsky Tumor necrosis factor-α enhances cytolytic activity of human natural killer cells J Immunol 138 1987 4185 4191
39. LM Coletti DG Remick GD Burtch SL Kunkel LM Streter DA Campbell Jr. Role of tumor necrosis factor-α in the pathophysiologic alterations after ischemia/reperfusion injury in the rat J Clin Invest 85 1990 1936 1943
40. B Naume R Shalaby W Lesslauer T. Espevik Involvement of the 55- and 75-kDa tumor necrosis factor receptors in the generation of lymphokine-activated killer cell activity and proliferation of natural killer cells J Immunol 146 1991 3045 3048
41. CS Lieber Alcohol and the liver: 1994 update Gastroenterology 106 1994 1085 1105
42. M Ingelman-Sundberg I Johansson H Yin Y Terelius E Eliasson P Clot E. Albano Ethanol-inducible cytochrome P450 2E1: genetic polymorphism, regulation and possible role in the etiology of alcohol-induced liver disease Alcohol 10 1993 447 452
43. C Garcia-Ruiz A Colell A Morales N Kaplowitz JC Fernandez-Checa Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes Mol Pharmacol 48 1995 825 834
44. N Kaplowitz H. Tsukamoto Oxidative stress and liver disease Prog Liver Dis 14 1996 131 159
45. JC Fernandez-Checa JR Yi C Garcia Ruiz M Ookhtens N. Kaplowitz Plasma membrane and mitochondrial transport of hepatic reduced glutathione Semin Liver Dis 16 1996 147 158
46. C Garcia-Ruiz A Morales A Colell A Ballesta J Rodes N Kaplowitz JC Fernandez-Checa Feeding S -adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes Hepatology 21 1995 207 214
47. N Kaplowitz JC Fernandez-Checa R Kannan C Garcia-Ruiz M Ookhtens JR Yi GSH transporters: molecular characterization and role in GSH homeostasis Biol Chem Hoppe Seyler 377 1996 267 273
48. T Hirano N Kaplowitz H Tsukamoto S Kamimura J. Fernandez-Checa Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats Hepatology 16 1992 1423 1427
49. C Garcia-Ruiz A Morales A Colell A Ballesta J Rodes N Kaplowitz JC Fernandez-Checa Effect of chronic ethanol feeding depletion on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes J Clin Invest 94 1994 193 201
50. A Morales C Garcia-Ruiz M Miranda M Mari A Colell A Ballesta E Ardite JC Fernandez-Checa Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of γ-glutamylcysteine synthetase J Biol Chem 272 1997 30371 30379
51. J Larrick S. Wright Cytotoxic mechanism of tumor necrosis factor–α FASEB J 4 1990 3215 3222
52. M Leist F Gantner H Naumann H Bluethmann K Vogt R Brigelius-Flohe P Nicotera HD Volk A. Wendel Tumor necrosis factor–induced apoptosis during the poisoning of mice with hepatotoxins Gastroenterology 112 1997 923 934