Antibody repertoire complexity and effector cell biology determined by assays for IgE-mediated basophil and T-cell activation

Journal of Immunological Methods

Volumn 383, Issue 1-2, 2012, Pages 4-20

  Lund, Gitte ^a   Willumsen, Nicholas ^a   Holm, Jens ^a   Christensen, Lars Harder ^a   Würtzen, Peter Adler ^a   Lund, Kaare ^a  

^a ALK ABELLÓ   (Denmark)

Author keywords

Basophil activation; Cytokine priming; Facilitated antigen presentation; IgE repertoire complexity; Specific immunotherapy

Indexed keywords

ALLERGEN; ANTIGEN; CD23 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN E RECEPTOR; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 3;

ALLERGY; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN PRESENTATION; B LYMPHOCYTE; BASOPHIL; COMPLEX FORMATION; CYTOKINE PRODUCTION; CYTOLOGY; EFFECTOR CELL; EXPERIMENTAL DESIGN; HUMAN; IMMUNOASSAY; INTERNALIZATION; MAST CELL; NONHUMAN; PARAMETERS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; REVIEW; T LYMPHOCYTE ACTIVATION; TEMPERATURE SENSITIVITY;

ALLERGENS; ANIMALS; ANTIGEN PRESENTATION; BASOPHILS; BIOLOGICAL MARKERS; CYTOKINES; HUMANS; HYPERSENSITIVITY; IMMUNITY, HUMORAL; IMMUNOGLOBULIN E; IMMUNOLOGIC TESTS; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RECEPTORS, IGE; T-LYMPHOCYTES;

EID: 84864389125     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2012.05.021     Document Type: Review

References (113)

1. Aalberse R.C., Kleine B.I., Stapel S.O., van R.R. Structural aspects of cross-reactivity and its relation to antibody affinity. Allergy 2001, 56(Suppl. 67):27.
2. Akdis C.A., Blesken T., Akdis M., Wuthrich B., Blaser K. Role of interleukin 10 in specific immunotherapy. J. Clin. Invest. 1998, 102:98.
3. Andreasson U., Flicker S., Lindstedt M., Valenta R., Greiff L., Korsgren M., Borrebaeck C.A., Ohlin M. The human IgE-encoding transcriptome to assess antibody repertoires and repertoire evolution. J. Mol. Biol. 2006, 362:212.
4. Blaiss M., Maloney J., Nolte H., Gawchik S., Yao R., Skoner D.P. Efficacy and safety of timothy grass allergy immunotherapy tablets in North American children and adolescents. J. Allergy Clin. Immunol. 2011, 127(64):71.
5. Blumberga G., Groes L., Dahl R. SQ-standardized house dust mite immunotherapy as an immunomodulatory treatment in patients with asthma. Allergy 2011, 66:178.
6. Buhring H.J., Streble A., Valent P. The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int. Arch. Allergy Immunol. 2004, 133:317.
7. Calderon M.A., Alves B., Jacobson M., Hurwitz B., Sheikh A., Durham S. Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst. Rev. 2007, CD001936.
8. Christensen L.H., Holm J., Lund G., Riise E., Lund K. Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J. Allergy Clin. Immunol. 2008, 122:298.
9. Christensen L.H., Riise E., Bang L., Zhang C., Lund K. Isoallergen variations contribute to the overall complexity of effector cell degranulation: effect mediated through differentiated IgE affinity. J. Immunol. 2010, 184:4966.
10. Coker H.A., Durham S.R., Gould H.J. Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients. J. Immunol. 2003, 171:5602.
11. Coker H.A., Harries H.E., Banfield G.K., Carr V.A., Durham S.R., Chevretton E., Hobby P., Sutton B.J., Gould H.J. Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis. J. Allergy Clin. Immunol. 2005, 116:445.
12. Cooper D., Hales J., Camp R. IgE-dependent activation of T cells by allergen in atopic dermatitis: pathophysiologic relevance. J. Invest. Dermatol. 2004, 123:1086.
13. Daeron M., Malbec O., Latour S., Arock M., Fridman W.H. Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J. Clin. Invest. 1995, 95:577.
14. Davies J.M., O'Hehir R.E. VH gene usage in immunoglobulin E responses of seasonal rhinitis patients allergic to grass pollen is oligoclonal and antigen driven. Clin. Exp. Allergy 2004, 34:429.
15. Davies J.M., O'Hehir R.E. Immunogenetic characteristics of immunoglobulin E in allergic disease. Clin. Exp. Allergy 2008, 38:566.
16. De Weck A.L., Sanz M.L. Cellular allergen stimulation test (CAST) 2003, a review. J. Investig. Allergol. Clin. Immunol. 2004, 14:253.
17. Devouassoux G., Foster B., Scott L.M., Metcalfe D.D., Prussin C. Frequency and characterization of antigen-specific IL-4- and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects. J. Allergy Clin. Immunol. 1999, 104:811.
18. Durham S.R., Gould H.J., Hamid Q.A. Local IgE production in nasal allergy. Int. Arch. Allergy Immunol. 1997, 113:128.
19. Durham S.R., Walker S.M., Varga E.M., Jacobson M.R., O'Brien F., Noble W., Till S.J., Hamid Q.A., Nouri-Aria K.T. Long-term clinical efficacy of grass-pollen immunotherapy. N. Engl. J. Med. 1999, 341:468.
20. Durham S.R., Emminger W., Kapp A., Colombo G., de Monchy J.G., Rak S., Scadding G.K., Andersen J.S., Riis B., Dahl R. Long-term clinical efficacy in grass pollen-induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet. J. Allergy Clin. Immunol. 2010, 125:131.
21. Ebo D.G., Hagendorens M.M., Bridts C.H., Schuerwegh A.J., De Clerck L.S., Stevens W.J. In vitro allergy diagnosis: should we follow the flow?. Clin. Exp. Allergy 2004, 34:332.
22. Ebo D.G., Dombrecht E.J., Bridts C.H., Aerts N.E., De Clerck L.S., Stevens W.J. Combined analysis of intracellular signalling and immunophenotype of human peripheral blood basophils by flow cytometry: a proof of concept. Clin. Exp. Allergy 2007, 37:1668.
23. Ejrnaes A.M., Svenson M., Lund G., Larsen J.N., Jacobi H. Inhibition of rBet v 1-induced basophil histamine release with specific immunotherapy-induced serum immunoglobulin G: no evidence that FcgammaRIIB signalling is important. Clin. Exp. Allergy 2006, 36:273.
24. Francis J.N., James L.K., Paraskevopoulos G., Wong C., Calderon M.A., Durham S.R., Till S.J. Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity. J. Allergy Clin. Immunol. 2008, 121:1120.
25. Gernez Y., Tirouvanziam R., Yu G., Ghosn E.E., Reshamwala N., Nguyen T., Tsai M., Galli S.J., Herzenberg L.A., Herzenberg L.A., Nadeau K.C. Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int. Arch. Allergy Immunol. 2011, 154:318.
26. Gibbs B.F. Human basophils as effectors and immunomodulators of allergic inflammation and innate immunity. Clin. Exp. Med. 2005, 5:43.
27. Gibbs B.F., Papenfuss K., Falcone F.H. A rapid two-step procedure for the purification of human peripheral blood basophils to near homogeneity. Clin. Exp. Allergy 2008, 38:480.
28. Gibbs B.F., Streatfield C., Falcone F.H. Basophils as critical orchestrators of Th2-type immune responses. Expert Rev. Clin. Immunol. 2009, 5:725.
29. Gober L.M., Eckman J.A., Sterba P.M., Vasagar K., Schroeder J.T., Golden D.B.K., Saini S.S. Expression of activation markers on basophils in a controlled model of anaphylaxis. J. Allergy Clin. Immunol. 2007, 119:1181.
30. Gould H.J., Sutton B.J. IgE in allergy and asthma today. Nat. Rev. Immunol. 2008, 8:205.
31. Gould H.J., Sutton B.J., Beavil A.J., Beavil R.L., McCloskey N., Coker H.A., Fear D., Smurthwaite L. The biology of IGE and the basis of allergic disease. Annu. Rev. Immunol. 2003, 21:579.
32. Hausmann O.V., Gentinetta T., Fux M., Ducrest S., Pichler W.J., Dahinden C.A. Robust expression of CCR3 as a single basophil selection marker in flow cytometry. Allergy 2011, 66:85.
33. Hauswirth A.W., Sonneck K., Florian S., Krauth M.T., Bohm A., Sperr W.R., Valenta R., Schernthaner G.H., Printz D., Fritsch G., Buhring H.J., Valent P. Interleukin-3 promotes the expression of E-NPP3/CD203C on human blood basophils in healthy subjects and in patients with birch pollen allergy. Int. J. Immunopathol. Pharmacol. 2007, 20:267.
34. Hennersdorf F., Florian S., Jakob A., Baumgartner K., Sonneck K., Nordheim A., Biedermann T., Valent P., Buhring H.J. Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. Cell Res. 2005, 15:325.
35. Holm J., Ferreras M., Ipsen H., Wurtzen P.A., Gajhede M., Larsen J.N., Lund K., Spangfort M.D. Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1. J. Biol. Chem. 2011, 286:17569.
36. Holm J., Willumsen N., Wurtzen P.A., Christensen L.H., Lund K. Facilitated antigen presentation and its inhibition by blocking IgG antibodies depends on IgE repertoire complexity. J. Allergy Clin. Immunol. 2011, 127:1029.
37. Honjo T., Kinoshita K., Muramatsu M. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol. 2002, 20:165.
38. Jones S.M., Pons L., Roberts J.L., Scurlock A.M., Perry T.T., Kulis M., Shreffler W.G., Steele P., Henry K.A., Adair M., Francis J.M., Durham S., Vickery B.P., Zhong X., Burks A.W. Clinical efficacy and immune regulation with peanut oral immunotherapy. J. Allergy Clin. Immunol. 2009, 124(292):300.
39. + T cells. Immunol. Today 1991, 12:392.
40. Karasuyama H., Mukai K., Tsujimura Y., Obata K. Newly discovered roles for basophils: a neglected minority gains new respect. Nat. Rev. Immunol. 2009, 9:9.
41. Kepley C.L., Youssef L., Andrews R.P., Wilson B.S., Oliver J.M. Multiple defects in Fc epsilon RI signaling in Syk-deficient nonreleaser basophils and IL-3-induced recovery of Syk expression and secretion. J. Immunol. 2000, 165:5913.
42. Kerzel S., Rogosch T., Struecker B., Maier R.F., Zemlin M. IgE transcripts in the circulation of allergic children reflect a classical antigen-driven B cell response and not a superantigen-like activation. J. Immunol. 2010, 185:2253.
43. Kirshenbaum A.S., Akin C., Wu Y., Rottem M., Goff J.P., Beaven M.A., Rao V.K., Metcalfe D.D. Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. Leuk. Res. 2003, 27:677.
44. Kleine-Tebbe J., Erdmann S., Knol E.F., MacGlashan D.W., Poulsen L.K., Gibbs B.F. Diagnostic tests based on human basophils: potentials, pitfalls and perspectives. Int. Arch. Allergy Immunol. 2006, 141:79.
45. Klunker S., Saggar L.R., Seyfert-Margolis V., Asare A.L., Casale T.B., Durham S.R., Francis J.N. Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: inhibition of IgE-facilitated allergen binding. J. Allergy Clin. Immunol. 2007, 120:688.
46. Kon O.M., Sihra B.S., Till S.J., Corrigan C.J., Kay A.B., Grant J.A. Unstimulated basophils in atopic and nonatopic subjects express intracellular interleukin-4: detection by flow cytometry. Allergy 1998, 53:891.
47. Kosnik M., Silar M., Bajrovic N., Music E., Korosec P. High sensitivity of basophils predicts side-effects in venom immunotherapy. Allergy 2005, 60:1401.
48. Lakey E.K., Casten L.A., Niebling W.L., Margoliash E., Pierce S.K. Time dependence of B cell processing and presentation of peptide and native protein antigens. J. Immunol. 1988, 140:3309.
49. Langdon J.M., Schroeder J.T., Vonakis B.M., Bieneman A.P., Chichester K., MacDonald S.M. Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models. J. Leukoc. Biol. 2008, 84:1151.
50. Lantto J., Haahr H.M., Rasmussen S.K., Steinaa L., Poulsen T.R., Duggan J., Dennis M., Naylor I., Easterbrook L., Bregenholt S., Haurum J., Jensen A. Capturing the natural diversity of the human antibody response against vaccinia virus. J. Virol. 2011, 85:1820.
51. Lin J., Renault N., Haas H., Schramm G., Vieths S., Vogel L., Falcone F.H., Alcocer M.J. A novel tool for the detection of allergic sensitization combining protein microarrays with human basophils. Clin. Exp. Allergy 2007, 37:1854.
52. Lourenco F.D., Azor M.H., Santos J.C., Prearo E., Maruta C.W., Rivitti E.A., Duarte A.J., Sato M.N. Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus. Br. J. Dermatol. 2008, 158:979.
53. Lund G., Jacobi H., Skov P.S., Holm J., Lund K. Effect on cell surface markers following allergen-induced desensitization of human whole-blood basophils. Int. Arch. Allergy Immunol. 2010, 153:323.
54. MacGlashan D.W. Releasability of human basophils: cellular sensitivity and maximal histamine release are independent variables. J. Allergy Clin. Immunol. 1993, 91:605.
55. Marth K., Novatchkova M., Focke-Tejkl M., Jenisch S., Jager S., Kabelitz D., Valenta R. Tracing antigen signatures in the human IgE repertoire. Mol. Immunol. 2010, 47:2323.
56. Matsumoto K., Maeda A., Bochner B.S., Wakiguchi H., Saito H. Induction of apoptosis in human basophils by anti-Fas antibody treatment in vitro. Int. Arch. Allergy Immunol. 2008, 146(Suppl. 1):40.
57. Melo A.C.S., Santos M.P., Ferreira M.B., Carlos M.P., Carlos A.P. Expression, in basophils, of activation molecule CD63 in patients with mites rhinitis submitted to specific immunotherapy. J. Allergy Clin. Immunol. 2004, 113:S107.
58. Mirza O., Henriksen A., Ipsen H., Larsen J.N., Wissenbach M., Spangfort M.D., Gajhede M. Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. J. Immunol. 2000, 165:331.
59. Mita H., Yasueda H., Akiyama K. Affinity of IgE antibody to antigen influences allergen-induced histamine release. Clin. Exp. Allergy 2000, 30:1583.
60. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989, 7:145.
61. Mothes N., Heinzkill M., Drachenberg K.J., Sperr W.R., Krauth M.T., Majlesi Y., Semper H., Valent P., Niederberger V., Kraft D., Valenta R. Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin. Exp. Allergy 2003, 33:1198.
62. Mudde G.C., van Reijsen F.C., Bruijnzeel-Koomen C.A. IgE-positive Langerhans cells and Th2 allergen-specific T cells in atopic dermatitis. J. Invest. Dermatol. 1992, 99:103S.
63. Mudde G.C., Bheekha R., Bruijnzeel-Koomen C.A. Consequences of IgE/CD23-mediated antigen presentation in allergy. Immunol. Today 1995, 16:380.
64. Mueller G.A., Smith A.M., Chapman M.D., Rule G.S., Benjamin D.C. Hydrogen exchange nuclear magnetic resonance spectroscopy mapping of antibody epitopes on the house dust mite allergen Der p 2. J. Biol. Chem. 2001, 276:9359.
65. Nelson H.S., Nolte H., Creticos P., Maloney J., Wu J., Bernstein D.I. Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults. J. Allergy Clin. Immunol. 2011, 127(72):80.
66. Neuberger M.S., Ehrenstein M.R., Rada C., Sale J., Batista F.D., Williams G., Milstein C. Memory in the B-cell compartment: antibody affinity maturation. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2000, 355:357.
67. Nopp A., Johansson S.G., Ankerst J., Bylin G., Cardell L.O., Gronneberg R., Irander K., Palmqvist M., Oman H. Basophil allergen threshold sensitivity: a useful approach to anti-IgE treatment efficacy evaluation. Allergy 2006, 61:298.
68. Nopp A., Johansson S.G., Lundberg M., Oman H. Simultaneous exposure of several allergens has an additive effect on multisensitized basophils. Allergy 2006, 61:1366.
69. Nopp A., Cardell L.O., Johansson S.G., Oman H. CD-sens: a biological measure of immunological changes stimulated by ASIT. Allergy 2009, 64:811.
70. Nouri-Aria K.T., Wachholz P.A., Francis J.N., Jacobson M.R., Walker S.M., Wilcock L.K., Staple S.Q., Aalberse R.C., Till S.J., Durham S.R. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J. Immunol. 2004, 172:3252.
71. Ono E., Taniguchi M., Higashi N., Mita H., Kajiwara K., Yamaguchi H., Tatsuno S., Fukutomi Y., Tanimoto H., Sekiya K., Oshikata C., Tsuburai T., Tsurikisawa N., Otomo M., Maeda Y., Hasegawa M., Miyazaki E., Kumamoto T., Akiyama K. CD203c expression on human basophils is associated with asthma exacerbation. J. Allergy Clin. Immunol. 2010, 125:483.
72. Pecaric-Petkovic T., Didichenko S.A., Kaempfer S., Spiegl N., Dahinden C.A. Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. Blood 2009, 113:1526.
73. Persson H., Sadegh M.K., Greiff L., Ohlin M. Delineating the specificity of an IgE-encoding transcriptome. J. Allergy Clin. Immunol. 2007, 120:1186.
74. Peternelj A., Silar M., Erzen R., Kosnik M., Korosec P. Basophil sensitivity in patients not responding to venom immunotherapy. Int. Arch. Allergy Immunol. 2008, 146:248.
75. Plewako H., Wosinska K., Arvidsson M., Bjorkander J., Skov P.S., Hakansson L., Rak S. Basophil interleukin 4 and interleukin 13 production is suppressed during the early phase of rush immunotherapy. Int. Arch. Allergy Immunol. 2006, 141:346.
76. Poulsen T.R., Meijer P.J., Jensen A., Nielsen L.S., Andersen P.S. Kinetic, affinity, and diversity limits of human polyclonal antibody responses against tetanus toxoid. J. Immunol. 2007, 179:3841.
77. Prussin C., Metcalfe D.D. 5. IgE, mast cells, basophils, and eosinophils. J. Allergy Clin. Immunol. 2006, 117:S450.
78. Radulovic S., Wilson D., Calderon M., Durham S. Systematic reviews of sublingual immunotherapy (SLIT). Allergy 2011, 66:740.
79. Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996, 381:751.
80. Romagnani S. Immunologic influences on allergy and the TH1/TH2 balance. J. Allergy Clin. Immunol. 2004, 113:395.
81. Roosnek E., Demotz S., Corradin G., Lanzavecchia A. Kinetics of MHC-antigen complex formation on antigen-presenting cells. J. Immunol. 1988, 140:4079.
82. Sampson H.A., Broadbent K.R., Bernhisel-Broadbent J. Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity. N. Engl. J. Med. 1989, 321:228.
83. Scadding G.W., Shamji M.H., Jacobson M.R., Lee D.I., Wilson D., Lima M.T., Pitkin L., Pilette C., Nouri-Aria K., Durham S.R. Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells. Clin. Exp. Allergy 2010, 40:598.
84. Schneider E., Thieblemont N., De Moraes M.L., Dy M. Basophils: new players in the cytokine network. Eur. Cytokine Netw. 2010, 21:142.
85. Schroeder J.T., Bieneman A.P., Chichester K.L., Breslin L., Xiao H., Liu M.C. Pulmonary allergic responses augment interleukin-13 secretion by circulating basophils yet suppress interferon-alpha from plasmacytoid dendritic cells. Clin. Exp. Allergy 2010, 40:745.
86. Shah D., Hales J., Cooper D., Camp R. Recognition of pathogenically relevant house dust mite hypersensitivity in adults with atopic dermatitis: a new approach?. J. Allergy Clin. Immunol. 2002, 109:1012.
87. Shamji M.H., Wilcock L.K., Wachholz P.A., Dearman R.J., Kimber I., Wurtzen P.A., Larche M., Durham S.R., Francis J.N. The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses. J. Immunol. Methods 2006, 317:71.
88. Shim J.Y., Kim B.S., Cho S.H., Min K.U., Hong S.J. Allergen-specific conventional immunotherapy decreases immunoglobulin E-mediated basophil histamine releasability. Clin. Exp. Allergy 2003, 33:52.
89. Shreffler W.G. Evaluation of basophil activation in food allergy: present and future applications. Curr. Opin. Allergy Clin. Immunol. 2006, 6:226.
90. Shreffler W.G., Beyer K., Chu T.H., Burks A.W., Sampson H.A. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J. Allergy Clin. Immunol. 2004, 113:776.
91. Siraganian R.P. Automated histamine analysis for in vitro allergy testing. II. Correlation of skin test results with in vitro whole blood histamine release in 82 patients. J. Allergy Clin. Immunol. 1977, 59:214.
92. Smithgall M.D., Comeau M.R., Yoon B.R., Kaufman D., Armitage R., Smith D.E. IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. Int. Immunol. 2008, 20:1019.
93. Spiegl N., Didichenko S., McCaffery P., Langen H., Dahinden C.A. Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid. Blood 2008, 112:3762.
94. Sullivan B.M., Locksley R.M. Basophils: a nonredundant contributor to host immunity. Immunity 2009, 30:12.
95. Thomas W.R., Hales B.J., Smith W.A. Genetically engineered vaccines. Curr. Allergy Asthma Rep. 2005, 5:197.
96. Turcanu V., Stephens A.C., Chan S.M., Rance F., Lack G. IgE-mediated facilitated antigen presentation underlies higher immune responses in peanut allergy. Allergy 2010, 65:1274.
97. Uermosi C., Beerli R.R., Bauer M., Manolova V., Dietmeier K., Buser R.B., Kundig T.M., Saudan P., Bachmann M.F. Mechanisms of allergen-specific desensitization. J. Allergy Clin. Immunol. 2010, 126:375.
98. van der Heijden F.L., Joost van Neerven R.J., van K.M., Bos J.D., Kapsenberg M.L. Serum-IgE-facilitated allergen presentation in atopic disease. J. Immunol. 1993, 150:3643.
99. van der Heijden F.L., van Neerven R.J., Kapsenberg M.L. Relationship between facilitated allergen presentation and the presence of allergen-specific IgE in serum of atopic patients. Clin. Exp. Immunol. 1995, 99:289.
100. + T cells by inhibiting serum-IgE-facilitated allergen presentation. J. Immunol. 1999, 163:2944.
101. van Neerven R.J., van Roomen C.P., Thomas W.R., de B.M., Knol E.F., Davis F.M. Humanized anti-IgE mAb Hu-901 prevents the activation of allergen-specific T cells. Int. Arch. Allergy Immunol. 2001, 124:400.
102. van Neerven R.J., Arvidsson M., Ipsen H., Sparholt S.H., Rak S., Wurtzen P.A. A double-blind, placebo-controlled birch allergy vaccination study: inhibition of CD23-mediated serum-immunoglobulin E-facilitated allergen presentation. Clin. Exp. Allergy 2004, 34:420.
103. van Neerven R.J., Knol E.F., Ejrnaes A., Wurtzen P.A. IgE-mediated allergen presentation and blocking antibodies: regulation of T-cell activation in allergy. Int. Arch. Allergy Immunol. 2006, 141:119.
104. Varga E.M., Francis J.N., Zach M.S., Klunker S., Aberer W., Durham S.R. Time course of serum inhibitory activity for facilitated allergen-IgE binding during bee venom immunotherapy in children. Clin. Exp. Allergy 2009, 39:1353.
105. Vasagar K., Vonakis B.M., Gober L.M., Viksman A., Gibbons S.P., Saini S.S. Evidence of in vivo basophil activation in chronic idiopathic urticaria. Clin. Exp. Allergy 2006, 36:770.
106. Wachholz P.A., Soni N.K., Till S.J., Durham S.R. Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy. J. Allergy Clin. Immunol. 2003, 112:915.
107. Wanich N., Nowak-Wegrzyn A., Sampson H.A., Shreffler W.G. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J. Allergy Clin. Immunol. 2009, 123:789.
108. Wickman M. When allergies complicate allergies. Allergy 2005, 60(Suppl. 79):14.
109. Wurtzen P.A., Lund G., Lund K., Arvidsson M., Rak S., Ipsen H. A double-blind placebo-controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation. Clin. Exp. Allergy 2008, 38:1290.
110. Xia Y.C., Sun S., Kuek L.E., Lopata A.L., Hulett M.D., Mackay G.A. Human mast cell line-1 (HMC-1) cells transfected with FcepsilonRIalpha are sensitive to IgE/antigen-mediated stimulation demonstrating selectivity towards cytokine production. Int. Immunopharmacol. 2011, 11:1002.
111. Yanagihara Y., Kajiwara K., Basaki Y., Ikizawa K., Ebisawa M., Ra C., Tachimoto H., Saito H. Cultured basophils but not cultured mast cells induce human IgE synthesis in B cells after immunologic stimulation. Clin. Exp. Immunol. 1998, 111:136.
112. Zhang N., Holtappels G., Gevaert P., Patou J., Dhaliwal B., Gould H., Bachert C. Mucosal tissue polyclonal IgE is functional in response to allergen and SEB. Allergy 2011, 66:141.
113. Zhu D., Kepley C.L., Zhang K., Terada T., Yamada T., Saxon A. A chimeric human-cat fusion protein blocks cat-induced allergy. Nat. Med. 2005, 11:446.