Humanized anti-IgE mAb Hu-901 prevents the activation of allergen-specific T cells

International Archives of Allergy and Immunology

Volumn 124, Issue 1-3, 2001, Pages 400-402

  Van Neerven, R J J ^a   Van Roomen, C P A A ^a   Thomas, W R ^c   De Boer, M ^a   Knol, E F ^b   Davis, F M ^d  

^a Tanox Pharma BV   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d Tanox Biosystems Inc   (United States)

Author keywords

Allergen; Anti IgE; Antigen presentation; T cell

Indexed keywords

ALLERGEN; CD23 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HU 901; UNCLASSIFIED DRUG;

ALLERGY; ASTHMA; B LYMPHOCYTE; BASOPHIL; CELL ACTIVATION; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DEGRANULATION; DERMATOPHAGOIDES PTERONYSSINUS; DOSE RESPONSE; ENDOCYTOSIS; HUMAN; HUMAN CELL; MAST CELL; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE;

ALLERGENS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; ANTIGENS, DERMATOPHAGOIDES; CELL LINE; GLYCOPROTEINS; HUMANS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES;

EID: 0035051574     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053770     Document Type: Conference Paper

References (10)

1. Serum IgE-facilitated allergen presentation in allergic disease
2. The high affinity IgE receptor (FcεRI) mediates IgE-dependent allergen presentation
3. Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibition serum-IgE-facilitated allergen presentation
4. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects
5. The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: Efficacy, safety, and pharmacokinetics
6. Immunoglobulin E-independent major histocompatibility complex-restricted T-cell peptide epitope-induced late asthmatic reactions
7. Inhibition of T-cell co-stimulation abrogates airway hyperresponsiveness in a murine model
8. Monoclonal antibodies specific for human IgE-producing B cells: A potential therapeutic for IgE-mediated allergic diseases
9. In vitro regulation of FcεRIa expression on human basophils by IgE antibody
10. Down-regulation of human basophil IgE and FcεRIα surface densities and mediators releaser by anti-IgE-infusions is reversible in vitro and in vivo