Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1

Journal of Biological Chemistry

Volumn 286, Issue 20, 2011, Pages 17569-17578

  Holm, Jens ^a   Ferreras, Mercedes ^a   Ipsen, Henrik ^a   Würtzen, Peter A ^a   Gajhede, Michael ^b   Larsen, Jørgen N ^a   Lund, Kaare ^a   Spangfort, Michael D ^a  

^a ALK ABELLÓ   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; ANTIBODY BINDING; BIACORE EXPERIMENTS; BINDING KINETICS; CONFORMATIONAL EPITOPES; CROSS-REACTIVITY; HIGH AFFINITY; HISTAMINE RELEASE; MALUS DOMESTICA; MOLECULAR SURFACES; ORAL ALLERGY SYNDROME; PARAMETERS CHARACTERIZING;

ALLERGIES; AMINO ACIDS; ANTIGENS; BINDING ENERGY; CONFORMATIONS; FRUITS; GENETIC ENGINEERING; GRAFTING (CHEMICAL);

ANTIBODIES;

EPITOPE; IMMUNOGLOBULIN E;

AMINO ACID SEQUENCE; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BETULA VERRUCOSA; BINDING KINETICS; BIOTINYLATION; BIRCH; CIRCULAR DICHROISM; CONTROLLED STUDY; CROSS REACTION; GENETIC ENGINEERING; GENETIC VARIABILITY; HISTAMINE RELEASE; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ALLERGENS; ANTIGENS, PLANT; EPITOPES; HUMANS; IMMUNOGLOBULIN E; PLANT PROTEINS; RECOMBINANT FUSION PROTEINS; RHINITIS, ALLERGIC, SEASONAL;

BETULA PENDULA; MALUS X DOMESTICA;

EID: 79955953910     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.194878     Document Type: Article

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