Kinetic, affinity, and diversity limits of human polyclonal antibody responses against tetanus toxoid

Journal of Immunology

Volumn 179, Issue 6, 2007, Pages 3841-3850

  Poulsen, Tine Rugh ^a   Meijer, Per Johan ^a   Jensen, Allan ^a   Nielsen, Lars S ^a   Andersen, Peter S ^a  

^a Symphogen AS   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCLONAL ANTIBODY; TETANUS TOXOID; BACTERIUM ANTIBODY; MONOCLONAL ANTIBODY;

ADULT; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; MOLECULAR CLONING; NORMAL HUMAN; PLASMA CELL; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SOMATIC MUTATION; AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; BIOSYNTHESIS; CLOSTRIDIUM TETANI; COMPLEMENTARITY DETERMINING REGION; GENE REARRANGEMENT; GENETICS; IMMUNOGLOBULIN STRUCTURE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MOLECULAR GENETICS;

ADULT; AMINO ACID SEQUENCE; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY DIVERSITY; CLOSTRIDIUM TETANI; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; HUMANS; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN VARIABLE REGION; KINETICS; MALE; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; TETANUS TOXOID;

EID: 35748954361     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.6.3841     Document Type: Article

References (26)

1. Neuberger, M. S. 2002. Novartis Medal Lecture, antibodies: a paradigm for the evolution of molecular recognition. Biochem. Soc. Trans. 30: 341-350.
2. Foote, J., and C. Milstein. 1991. Kinetic maturation of an immune response. Nature 352: 530-532.
3. Sagawa, T., M. Oda, M. Ishimura, K. Furukawa, and T. Azuma. 2003. Thermodynamic and kinetic aspects of antibody evolution during the immune response to hapten. Mol. Immunol. 39: 801-808.
4. Liu, J., L. Liu, and R. Jemmerson. 2000. Immunoglobulin gene joints compensate for reduced on-rates imposed by somatic mutations in a VH gene. Mol. Immunol. 37: 95-105.
5. Roost, H. P., M. F. Bachmann, A. Haag, U. Kalinke, V. Pliska, H. Hengartner, and R. M. Zinkernagel. 1995. Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity. Proc. Natl. Acad. Sci. USA 92: 1257-1261.
6. Goldbaum, F. A., A. Cauerhff, C. A. Velikovsky, A. S. Llera, M. M. Riottot, and R. J. Poljak. 1999. Lack of significant differences in association-rates and affinities of antibodies from short-term and long-term responses to hen egg lysozyme. J. Immunol. 162: 6040-6045.
7. Foote, J., and H. N. Eisen. 1995. Kinetic and affinity limits on antibodies produced during immune responses. Proc. Natl. Acad. Sci. USA 92: 1254-1256.
8. Kramer, R. A., W. E. Marissen, J. Goudsmit, T. J. Visser, M. Clijsters-Van der Horst, A. Q. Bakker, M. de Jong, M. Jongeneelen, S. Thijsse, H. H. Backus, et al. 2005. The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries. Eur. J. Immunol. 35: 2131-2145.
9. Ohlin, M., H. Owman, M. Mach, and C. A. Borrebaeck. 1996. Light chain shuffling of a high affinity antibody results in a drift in epitope recognition. Mol. Immunol. 33: 47-56.
10. Meijer, P. J., P. S. Andersen, H. M. Haahr, L. Steinaa, A. Jensen, J. Lantto, M. B. Oleksiewicz, K. Tengbjerg, T. R. Poulsen, V. W. Coljee, et al. 2006. Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing. J. Mol. Biol. 358: 764-772.
11. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22: 4673-4680.
12. Behlke, M. A., D. G. Spinella, H. S. Chou, W. Sha, D. L. Hartl, and D. Y. Loh. 1985. T-cell receptor β-chain expression: dependence on relatively few variable region genes. Science 229: 566-570.
13. + B cells. J. Clin. Invest. 99: 2488-2501.
14. + B cells. J. Clin. Invest. 99: 1614-1627.
15. Andersen, P. S., M. Haahr-Hansen, V. W. Coljee, F. R. Hinnerfeldt, K. Varming, S. Bregenholt, and J. S. Haurum. 2007. Extensive restrictions in the VH sequence usage of the human antibody response against the Rhesus D antigen. Mol. Immunol. 44: 412-422.
16. Adderson, E. E., P. G. Shackelford, A. Quinn, P. M. Wilson, M. W. Cunningham, R. A. Insel, and W. L. Carroll. 1993. Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide: nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens. J. Clin. Invest. 91: 2734-2743.
17. Kaartinen, M., G. M. Griffiths, A. F. Markham, and C. Milstein. 1983. mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification. Nature 304: 320-324.
18. Wu, T. T., G. Johnson, and E. A. Kabat. 1993. Length distribution of CDRH3 in antibodies. Proteins 16: 1-7.
19. Nemazee, D., and M. Weigert. 2000. Revising B cell receptors. J. Exp. Med. 191: 1813-1817.
20. de Wildt, R. M., R. M. Hoet, W. J. van Venrooij, I. M. Tomlinson, and G. Winter. 1999. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J. Mol. Biol. 285: 895-901.
21. Ohlin, M., and C. A. Borrebaeck. 1996. Characteristics of human antibody repertoires following active immune responses in vivo. Mol. Immunol. 33: 583-592.
22. Newman, M. A., C. R. Mainhart, C. P. Mallett, T. B. Lavoie, and S. J. Smith-Gill. 1992. Patterns of antibody specificity during the BALB/c immune response to hen eggwhite lysozyme. J. Immunol. 149: 3260-3272.
23. Vaughan, T. J., A. J. Williams, K. Pritchard, J. K. Osbourn, A. R. Pope, J. C. Earnshaw, J. McCafferty, R. A. Hodits, J. Wilton, and K. S. Johnson. 1996. Human antibodies with sub-nanomolar affinities isolated from a large nonimmunized phage display library (see comments). Nat. Biotechnol. 14: 309-314.
24. Guermonprez, P., P. England, H. Bedouelle, and C. Leclerc. 1998. The rate of dissociation between antibody and antigen determines the efficiency of antibody-mediated antigen presentation to T cells. J. Immunol. 161: 4542-4548.
25. Batista, F. D., and M. S. Neuberger. 1998. Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. Immunity 8: 751-759.
26. Furukawa, K., A. Akasako-Furukawa, H. Shirai, H. Nakamura, and T. Azuma. 1999. Junctional amino acids determine the maturation pathway of an antibody. Immunity 11: 329-338.