Mechanistic assessment of dna ligase as an antibacterial target in Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 8, 2012, Pages 4095-4102

  Podos, Steven D ^a   Thanassi, Jane A ^a   Pucci, Michael J ^a  

^a Achillion Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CHROMAN DERIVATIVE; CIPROFLOXACIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; OLIGONUCLEOTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PYRIDINE DERIVATIVE; PYRIDOCHROMANONE; UNCLASSIFIED DRUG;

ADENYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL GENE; BACTERIAL STRAIN; BINDING AFFINITY; CLONE; COMPETITIVE INHIBITION; COVALENT BOND; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; GROWTH RATE; IC 50; IN VITRO STUDY; LIGA GENE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MUTANT; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANTI-BACTERIAL AGENTS; DNA LIGASES; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MUTANT PROTEINS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84864383695     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00215-12     Document Type: Article

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