Cloning and functional characterization of an NAD+-dependent DNA ligase from Staphylococcus aureus

Journal of Bacteriology

Volumn 183, Issue 10, 2001, Pages 3016-3024

  Kaczmarek, Frank S ^a   Zaniewski, Richard P ^a   Gootz, Thomas D ^a   Danley, Dennis E ^a   Mansour, Mahmoud N ^a   Griffor, Matt ^a   Kamath, Ajith V ^a   Cronan, Melissa ^a   Mueller, John ^a   Sun, Dongxu ^b,c   Martin, Patrick K ^b   Benton, Bret ^b   McDowell, Laura ^b   Biek, Donald ^b   Schmid, Molly B ^d  

^a PFIZER INC   (United States)

^b Microcide Pharmaceuticals Inc   (United States)

^c Entelos Inc   (United States)

^d Genecor International   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA REPLICATION; DNA STRAND BREAKAGE; GENETIC CODE; GENETIC COMPLEMENTATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS; TARGET CELL;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CLONING, MOLECULAR; DNA LIGASES; ESCHERICHIA COLI; GENETIC COMPLEMENTATION TEST; MOLECULAR SEQUENCE DATA; MUTATION; NAD; SEQUENCE ANALYSIS, DNA; STAPHYLOCOCCUS AUREUS; TEMPERATURE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; GEOBACILLUS STEAROTHERMOPHILUS; LIGA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 0035040993     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.183.10.3016-3024.2001     Document Type: Article

References (30)

1. Barker, D. G., A. L. Johnson, and L. H. Johnston. 1985. An improved assay for DNA ligase reveals temperature-sensitive activity in cdc9 mutants of Saccharomyces cerevisiae. Mol. Gen. Genet. 200:458-462.
2. Dermody, J. J., G. T. Robinson, and R. Sternglanz. 1979. Conditional-lethal deoxyribonucleic acid ligase mutant of Escherichia coli. J. Bacteriol. 139:701-704.
3. Doherty, A. J., S. R. Ashford, and D. B. Wigley. 1996. Characterization of the proteolytic fragments of bacteriophage T7 DNA ligase. Nucleic Acids Res. 24:2281-2287.
4. Halligan, B. 1993. A new protein motif found in DNA joining and DNA binding proteins. Nucleic Acids Res. 21:5520-5521.
5. Horinouchi, S., and B. Weisblum. 1982. Nucleotide sequence and functional map of pE194, a plasmid that specifies inducible resistance to macrolide, lincosamide and streptogramin type B antibiotics. J. Bacteriol. 150:804-814.
6. Iordanescu, S. 1993. Characterization of the Staphylococcus aureus chromosomal gene pcrA, identified by mutations affecting plasmid replication. Mol. Gen. Genet. 241:185-192.
7. Ishino, Y., H. Shinagawa, K. Makino, S. Tsunasawa, F. Sakiyama, and A. Nakata. 1986. Nucleotide sequenee of the lig gene and primary structure of DNA ligase of Escherichia coli. Mol. Gen. Genet. 204:1-7.
8. Jonsson, A. O., S. H. Thorbjarnardottir, G. Eggertsson, and A. Palsdottir. 1994. Sequence of the DNA ligase-encoding gene from Thermus scotoductus and conserved motifs in DNA ligases. Gene 151:177-180.
9. Lauer, G., E. A. Rudd, D. L. McKay, A. Ally, D. Ally, and K. C. Backman. 1991. Cloning, nucleotide sequence, and engineered expression of Thermus thermophilus DNA ligase, a homolog of Escherichia coli DNA ligase. J. Bacteriol. 173:5047-5053.
10. +-dependent DNA ligase: modular architecture and functional implications. EMBO J. 19:1119-1129.
11. Liebert, J. C., L. Paolozzi, M. G. Camera, A. M. Pedrini, and P. Ghelardini. 1989. The expression of the DNA ligase gene of Escherichia coli is stimulated by relaxation of chromosomal supercoiling. Mol. Microbiol. 3:269-273.
12. Luo, J., and F. Barany. 1996. Identification of essential residues in Thermus thermophilus DNA ligase. Nucleic Acids Res. 24:3079-3085.
13. Martin, P., T. Li, D. Sun, D. P. Biek, and M. B. Schmid. 1999. Role in cell permeability of an essential two-component system in Staphylococcus aureus. J. Bacteriol. 181:3666-3673.
14. Maxam, A. M., and W. Gilbert. 1977. A new method for sequencing DNA. Proc. Natl. Acad. Sci. USA 74:560-564.
15. Modrich, P., Y. Anraku, and I. R. Lehman. 1973. Deoxyribonucleic acid ligase: isolation and physical characterization of the homogeneous enzyme from Escherichia coli. J. Biol. Chem. 248:7495-7501.
16. Modrich, P., and I. R. Lehman. 1973. Deoxyribonucleic acid ligase: a steady state kinetic analysis of the reaction catalyzed by the enzyme from Escherichia coli. J. Biol. Chem. 248:7502-7511.
17. Montecucco, A., G. Pedrali-Noy, S. Spadari, and G. Ciarrocchi. 1988. Multiple roles of DNA ligase at the replication fork. Biochem. Biophys. Acta 951:330-334.
18. Panasenko, S. M., P. Modrich, and I. R. Lehman. 1976. Modification of Escherichia coli DNA ligase by cleavage with trypsin. J. Biol. Chem. 251: 3432-3435.
19. Pfaller, M. A., R. N. Jones, G. V. Doern, K. Kugler, and The Sentry Participants Group. 1998. Bacterial pathogens isolated from patients with bloodstream infection: frequencies of occurrence and antimicrobial susceptibility patterns from the SENTRY surveillance program (United States and Canada, 1997). Antimicrob. Agents Chemother. 42:1762-1770.
20. Saden, H. S., R. N. Jones, A. C. Gales, P. Winokukr, K. C. Kugler, et al. 1998. Antimicrobial susceptibility patterns from pathogens isolated from patients in Latin American medical centers with a diagnosis of pneumonia: analysis of results from the SENTRY antimicrobial surveillance program (1997). Diagn. Microbiol. Infect. Dis. 32:289-301.
21. Shark, K. B., and T. Conway. 1992. Cloning and molecular characterization of the DNA ligase gene (lig) from Zymomonas mobilis. FEMS Microbiol. Lett. 96:19-26.
22. +-dependent DNA ligase. Structure 7:35-42.
23. Subramanya, H. S., A. J. Doherty, S. R. Ashford, and D. B. Wigley. 1996. Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7. Cell 85:607-615.
24. Takahasi, M., E. Yamaguchi, and T. Uchida. 1984. Thermophilic DNA ligase: purification and properties of the enzyme from Thermus shermophilus HB8. J. Biol. Chem. 259:10041-10047.
25. Teraoki, H., and K. Tsukada. 1982. Eukaryotic DNA ligase: purification and properties of the enzyme from bovine thymus, and immunochemical studies of the enzyme from animal tissues. J. Biol. Chem. 257:4758-4763.
26. Thorbjarnardottir, S. H., Z. O. Jonsson, O. S. Andresson, J. K. Kristjansson, G. Eggertsson, and A. Palsdottir. 1995. Cloning and sequence analysis of the DNA ligase-encoding gene of Rhodothermus marinus, and overproduction, purification and characterization of two thermophilic DNA ligases. Gene 161:1-6.
27. Timson, D. J., M. R. Singleton, and D. B. Wigley. 2000. DNA ligases in the repair and replication of DNA. Mutat. Res. 460:301-318.
28. +-dependent DNA ligase. J. Mol. Biol. 285:73-83.
29. Tomkinson, A. E., N. F. Totty, M. Ginsburg, and T. Lindahl. 1991. Location of the active site for enzyme-adenylate formation in DNA ligases. Proc. Natl. Acad. Sci. USA 88:400-404.
30. Zimmerman, S. B., and B. H. Pheiffer. 1983. Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli. Proc. Natl. Acad. Sci. USA 80:5852-5856.