Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA)

Journal of Biological Chemistry

Volumn 280, Issue 13, 2005, Pages 12137-12144

  Zhu, Hui ^a   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG PRODUCTS; ESCHERICHIA COLI; GENETIC ENGINEERING; GROWTH KINETICS; MICROBIOLOGY;

ANTIMICROBIAL DRUGS; BACTERIAL GROWTH; DNA LIGASE; MUTATION;

ENZYMES;

ALANINE; AMINO ACID; ARGININE; ASPARTIC ACID; BACTERIAL ENZYME; GLUTAMINE; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE DEPENDENT POLYDEOXYRIBONUCLEOTIDE SYNTHASE; NUCLEOTIDYLTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG;

ADENYLATION; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION;

ALANINE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; ARGININE; BINDING SITES; CLONING, MOLECULAR; DNA; DNA LIGASES; DNA MUTATIONAL ANALYSIS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GLUTAMIC ACID; LYSINE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 16844373913     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413685200     Document Type: Article

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