Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones

Journal of Biological Chemistry

Volumn 278, Issue 41, 2003, Pages 39435-39442

  Brötz Oesterhelt, Heike ^a   Knezevic, Igor ^a   Bartel, Stephan ^a   Lampe, Thomas ^a   Warnecke Eberz, Ute ^a,b   Ziegelbauer, Karl ^a   Häbich, Dieter ^a   Labischinski, Harald ^a  

^a BAYER AG   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME INHIBITION; ESCHERICHIA COLI; FLUORESCENCE; MUTAGENESIS; PHYSIOLOGY;

PATHOGENS;

BIOCHEMISTRY;

ANTIBIOTIC AGENT; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PYRIDOCHROMANONE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DEGRADATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; EUKARYOTIC CELL; FLUORESCENCE MICROSCOPY; IC 50; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; TEMPERATURE SENSITIVITY;

ADENOSINE MONOPHOSPHATE; BASE SEQUENCE; CHROMANS; DNA LIGASES; DNA, BACTERIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; NEGIBACTERIA; POSIBACTERIA; PROKARYOTA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0141994876     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306479200     Document Type: Article

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