Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 3, 2011, Pages 1088-1096

  Mills, Scott D ^a   Eakin, Ann E ^a   Buurman, Ed T ^a   Newman, Joseph V ^a   Gao, Ning ^a   Huynh, Hoan ^a   Johnson, Kenneth D ^a   Lahiri, Sushmita ^a   Shapiro, Adam B ^a   Walkup, Grant K ^a   Yang, Wei ^a   Stokes, Suzanne S ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOBENZOTRIAZOLE; ANTIBIOTIC AGENT; HYDROXYPROPYLMETHYLCELLULOSE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ADENYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL LOAD; BACTERICIDAL ACTIVITY; BACTERIOPHAGE; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; HIGH THROUGHPUT SCREENING; IC 50; LUNG INFECTION; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; MOUSE; MYCOPLASMA PNEUMONIA; MYCOPLASMA PNEUMONIAE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-BACTERIAL AGENTS; DNA LIGASES; ENZYME INHIBITORS; FEMALE; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 79952353538     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01181-10     Document Type: Article

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