2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 29, 2012, Pages 7262-7269

  Wu, Man Ru ^a   Hou, Ming Hon ^b   Lin, Ya Lin ^a   Kuo, Chia Feng ^a  

^a SHIH CHIEN UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

2,4,5 TMBA; 3T3 L1 adipocyte; adipogenesis; lipolysis

Indexed keywords

2,4,5-TMBA; 3T3-L1 ADIPOCYTES; ACETYL-COA CARBOXYLASE; ADIPOCYTES; ADIPOGENESIS; ADIPOGENIC; CCAAT/ENHANCER-BINDING PROTEINS; COX-2 INHIBITORS; CYCLOOXYGENASE 2; EXTRACELLULAR SIGNAL-REGULATED KINASE; HIGH COSTS; HORMONE-SENSITIVE LIPASE; IN-VITRO; IN-VIVO; LIPID ACCUMULATIONS; LIPID DROPLETS; LIPID SYNTHESIS; LIPOLYSIS; MAP KINASE; NATURAL PRODUCTS; PERILIPIN; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PLANT ROOTS; PREADIPOCYTES; PROTEIN LEVEL; RATE-LIMITING ENZYMES; SIDE EFFECT; SIGNALING MOLECULES; UP-REGULATION;

BIOSYNTHESIS; CYTOLOGY; DROPS; DRUG INTERACTIONS; MOLECULAR WEIGHT; NUTRITION; SEED; TRANSCRIPTION FACTORS;

ENZYMES;

2,4,5 TRIMETHOXYBENZALDEHYDE; 2,4,5-TRIMETHOXYBENZALDEHYDE; ANTIOBESITY AGENT; BENZALDEHYDE DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR;

ADIPOCYTE; ADIPOGENESIS; ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; LIPID METABOLISM; LIPOLYSIS; METABOLISM; MOUSE; PLANT;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; ANTI-OBESITY AGENTS; BENZALDEHYDES; CELL DIFFERENTIATION; CELL SURVIVAL; CYCLOOXYGENASE 2 INHIBITORS; LIPID METABOLISM; LIPOLYSIS; MICE; PLANTS;

MURINAE;

EID: 84864357306     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf302285k     Document Type: Article

References (35)

1. Tang, Q. Q.; Otto, T. C.; Lane, M. D. Mitotic clonal expansion: a synchronous process required for adipogenesis Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 44-49
2. Yeh, W. C.; Cao, M.; Casson, M.; Mcknight, S. L. Cascade regulation of adipocyte terminal differentiation by three members of the C/EBP family of leucine zipper proteins Genes Dev. 1995, 15, 168-181
3. Feve, B. Adipogenesis: cellular and molecular aspects Best Pract. Res. Clin. Endocrinol. Metab. 2005, 19, 483-499
4. Prusty, D.; Park, B.-H.; Davis, K. E.; Farmer, S. R. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor γ (PPAR)γ and C/EBPα gene expression during the differentiation of 3T3-L1 preadipocytes J. Biol. Chem. 2002, 277, 46226-46232
5. Momin, R. A.; De Witt, D. L.; Nair, M. G. Inhibition of cyclooxygenase (COX) enzymes by compounds from Daucus carota L. seeds Phytother. Res. 2003, 17, 976-979
6. Ghoshal, S.; Trivedi, D. B.; Graf, G. A.; Loftin, C. D. Cyclooxygenase-2 deficiency attenuates adipose tissue differentiation and inflammation in mice J. Biol. Chem. 2011, 286, 889-898
7. Kiewer, S. A.; Lenhard, J. M.; Willson, T. M.; Paterl, I.; Morris, D. C.; Lehmann, J. M. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation Cell 1995, 83, 813-819
8. Fajas, L.; Miard, S.; Briggs, M. R.; Auwerx, J. Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase J. Lipid Res. 2003, 44, 1652-1659
9. Green, H.; Kehinde, O. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion Cell 1975, 5, 19-27
10. Kang, S.-I.; Kim, M.-H.; Shin, H.-S.; Kim, J.-M.; Hong, Y.-S.; Park, J.-G.; Ko, H.-C.; Lee, N.-H.; Chung, W.-S.; Kim, S.-J. A water-soluble extract of Petalonia binghamiae inhibits the expression of adipogenic regulators in 3T3-L1 preadipocytes and reduces adiposity and weight gain in rats fed a high-fat diet J. Nutr. Biochem. 2010, 21, 1251-1257
11. Newton, B. W.; Cologna, S. M.; Moya, C.; Russel, D. H.; Russel, W. K.; Jayaraman, A. Proteomic analysis of 3T3-L1 adipocyte mitochondria during differentiation and enlargement J. Proteome Res. 2011, 10, 4692-4702
12. Bost, F.; Aouadi, M.; Caron, L.; Binetruy, B. The role of MAPKs in adipocyte differentiation and obesity Biochimie 2005, 87, 51-56
13. Bost, F.; Aouadi, M.; Caron, L.; Even, P.; Belmonte, N.; Prot, M.; Dani, C.; Hofman, P.; Pages, G.; Marchand-Brustel, Y. L.; Binetruy, B. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis Diabetes 2005, 54, 402-411
14. Hirosumi, J.; Tuncman, G.; Chang, L.; Görgün, C. Z.; Teoman Yysal, K.; Maeda, K.; Karin, M.; Hotamisllgil, G. S. A central role for JNK in obesity and insulin resistance Nature 2002, 420, 333-336
15. Aouadi, M.; Jager, J.; Kaurent, K.; Gonzalez, T.; Cormont, M.; Binetruy, B.; Le Marchand-Brustel, Y.; Tanti, J.-F.; Bost, F. p38MAP kinase activity is required for human primary adipocyte differentiation FEBS Lett. 2007, 581, 5591-5596
16. Lii, C.-K.; Huang, C.-Y.; Chen, H.-W.; Chow, M.-Y.; Lin, Y.-R.; Huang, C.-S.; Tsai, C.-W. Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation Food Chem. Toxicol. 2012, 50, 478-484
17. Kim, H.; Sakamoto, K. (-)-Epigallocatechin gallate suppresses adipocyte differentiation through the MEK/ERK and PI3K/Akt pathways Cell Biol. Int. 2012, 36, 147-153
18. Wang, T.; Wang, Y.; Yamashita, H. Evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway FEBS Lett. 2009, 583, 3655-3659
19. Farmer, S. R. Transcriptional control of adipocyte formation Cell Metab. 2006, 4, 263-273
20. Tanaka, T.; Yoshida, N.; Kishimoto, T.; Akira, S. Defective adipocyte differentiation in mice lacking the C/EBP-beta and/or C/EBP-delta gene EMBO J. 1997, 16, 7432-7443
21. Rosen, E. D.; Hsu, C. H.; Wang, X.; Sakai, S.; Freeman, M. W.; Gonzalez, F. J.; Spiegelman, B. M. C/EBPalpha induces adipogenesis through PPARgamma: a united pathway Genes Dev. 2002, 16, 22-26
22. Kim, J. B.; Spiegelman, B. M. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism Genes Dev. 1996, 10, 1096-1107
23. Hsu, C.-L.; Yen, G.-C. Effects of capsacin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells J. Agric. Food Chem. 2007, 55, 1730-1736
24. Yang, J.-Y.; Della-Fera, M. A.; Rayalam, S.; Ambati, S.; Hartzell, D. L.; Park, H. J.; Baile, C. A. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combination of resveratrol and quercetin Life Sci. 2008, 82, 1032-1039
25. Ejaz, A.; Wu, D.; Kwan, P.; Meydani, M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice J. Nutr. 2009, 139, 919-925
26. Wolins, N. E.; Quaynor, B. K.; Skinner, J. R.; Schoenfish, M. J.; Tzekov, A.; Bicket, P. E. S3-12, adipophilin, and TIP47 package lipid in adipocytes J. Biol. Chem. 2005, 280, 19146-19155
27. Tansey, J. T.; Sztalryd, C.; Gruia-Gray, J.; Roush, D. L.; Zee, J. V.; Gavrilova, O; Reitman, M. L.; Deng, C.-X.; Li, C.; Kimmel, A. R.; Londos, C. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 6494-6499
28. Kern, P. A.; Di Gregorio, G.; Lu, T.; Rassouli, N.; Ranganathan, G. Perilipin expression in human adipose tissue is elevated with obesity J. Clin. Endocrinol. Metab. 2004, 89, 1352-1358
29. Brasaemle, D. L. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis J. Lipid Res. 2007, 48, 2547-2559
30. Lafontan, M.; Langin, D. Lipolysis and lipid mobilization in human adipose tissue Prog. Lipid Res. 2009, 48, 275-297
31. Brasaemle, D. L.; Levin, D. M.; Adler-Wailes, D. C.; Londos, C. The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets Biochim. Biophys. Acta 2000, 1483, 251-262
32. Matsubara, M; Maruoka, S.; Katayose, S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women Eur. J. Endocrinol. 2002, 147, 173-180
33. Matsuzawa, Y. The metabolic syndrome and adipocytokines FEBS Lett. 2006, 580, 2917-2921
34. Reinehr, T.; Roth, C.; Menke, T.; Andler, W. Adiponectin before and after weight loss in obese children J. Clin. Endocrinol. Metab. 2004, 89, 3790-3794
35. Maeda, N.; Takahashi, M.; Funahashi, T.; Kihara, S.; Nishizawa, H.; Kishida, K.; Nagaretani, H.; Matsuda, M.; Komuro, R.; Ouchi, N.; Kuriyama, H.; Hotta, K.; Nakamura, T.; Shimomura, I.; Matsuzawa, Y. PPARγ lignads increase expression and plasma concentrations of adiponectin, an adipose-derived protein Diabetes 2001, 50, 2094-2099