Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562

Investigational New Drugs

Volumn 30, Issue 3, 2012, Pages 862-869

  Hazawa, Masaharu ^a   Kudo, Michiko ^a   Iwata, Toshihiro ^a   Saito, Kazuki ^a   Takahashi, Kenji ^b   Igarashi, Jun ^c   Suga, Hiroaki ^c   Kashiwakura, Ikuo ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptosis; Chronic myeloid leukemia; Quorum sensing; Structure activity relationship

Indexed keywords

ANTINEOPLASTIC AGENT; AUTOINDUCER DERIVATIVE; CASPASE; PROTEIN P21; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL POPULATION; CELL STRAIN K 562; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUORUM SENSING; STRUCTURE ACTIVITY RELATION;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE INHIBITORS; CELL CYCLE; CELL PROLIFERATION; CYSTEINE PROTEINASE INHIBITORS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; K562 CELLS; LACTONES; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; P21-ACTIVATED KINASES; QUORUM SENSING;

EID: 84864326782     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9623-z     Document Type: Article

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