Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth

Investigational New Drugs

Volumn 27, Issue 2, 2009, Pages 111-119

  Hazawa, Masaharu ^a   Wada, Koji ^b   Takahashi, Kenji ^a   Mori, Takao ^c   Kawahara, Norio ^c   Kashiwakura, Ikuo ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^c North Japan Chemical Inc   (Japan)

Author keywords

Aconitum alkaloid; Anticancer drugs; C20 diterpenoid alkaloids; Radiation sensitization

Indexed keywords

ACONITUM EXTRACT; ALKALOID DERIVATIVE; DITERPENOID; HISTONE H2AX; ALKALOID; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; H2AFX PROTEIN, HUMAN; HISTONE; PLANT MEDICINAL PRODUCT; RADIOSENSITIZING AGENT;

ACONITUM; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE PHASE; CELL GROWTH; CLONOGENIC ASSAY; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIZATION; CELL CYCLE; CELL PROLIFERATION; CHEMISTRY; DRUG SCREENING; ISOLATION AND PURIFICATION; METABOLISM; MULTIMODALITY CANCER THERAPY; NEOPLASM; PLANT ROOT; RADIATION EXPOSURE; TUMOR CELL LINE;

ACONITUM; ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COMBINED MODALITY THERAPY; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONES; HUMANS; NEOPLASMS; PLANT PREPARATIONS; PLANT ROOTS; RADIATION-SENSITIZING AGENTS;

EID: 66949138245     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9141-4     Document Type: Article

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