Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation

Blood

Volumn 95, Issue 3, 2000, Pages 776-782

  Shi, Chong Shan ^b   Tuscano, Joseph ^b   Kehrl, John H ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BCR ABL PROTEIN; PROTEIN SERINE THREONINE KINASE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

EID: 0034142337     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.3.776.003k23_776_782     Document Type: Article

References (34)

1. Herskowitz I. MAP kinase pathways in yeast-for mating and much more. Cell. 1995;80:187.
2. Pryciak PM, Huntress FA. Membrane recruitment of the kinase cascade scaffold protein Ste5 by the G beta gamma complex underlies activation of the yeast pheromone response pathway. Genes Dev. 1998;12:2684.
3. Sells M, Chernoff J. Emerging from the PAK: the p21-activated protein kinase family. Trends Cell Biol. 1997;7:162.
4. Kyriakis JM, Avruch J. Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem. 1996;271:24,313.
5. Kyriakis J. Signaling by the germinal center kinase family of protein kinase. J Biol Chem. 1999; 274:5259.
6. Katz P, Whalen G, Kehrl JH. Differential expression of a novel protein kinase in human B lymphocytes. J Biol Chem. 1994;269:16,802.
7. Shi CS, Kehrl JH. Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-κB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway. J Biol Chem. 1997;51:32,102.
8. Tung RM, Blenis J. A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase. Oncogene. 1997;14:653.
9. Diener K, Wang XS, Chen C, et al. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc Natl Acad Sci U S A. 1997;94:9687.
10. Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes Dev. 1996;10:2251.
11. Kiefer F, Tibbies LA, Anfafi M, et al. HPK1, a hematopoietic protein kinase activating the SAPK/ JNK pathway. EMBO J. 1996;15:7013.
12. Su YC, Han J, Xu S, Cobb M, Skolnik EY. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 1997; 16:1279.
13. Pombo C, Kehrl JH, Sanchez I, et al. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature. 1995;377: 750.
14. Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T. SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1. J Biol Chem. 1997;272:27,804.
15. Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH. TNF mediated activation of the SAPK pathway: TNF receptor-associated factor-2 recruits and activates GCKR. J Immunol. 1999;163:3279.
16. Oehrl W, Kardinal C, Ruf S, et al. The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oncogene. 1998;17:1893.
17. Kiyokawa E, Mochizuki N, Kurata T, Matsuda M. Role of Crk oncogene product in physiologic signaling. Crit Rev Oncog. 1997;8:329.
18. Sattler M, Salgia R. Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells. Leukemia. 1998;12:637.
19. Matsuda M, Ota S, Tanimura R, et al. Interaction between the aminoterminal SH3 domain of Crk and its natural target proteins. J Biol Chem. 1996; 271:14,468.
20. Posern G, Zheng J, Knudsen BS, et al. Development of highly selective SH3 binding peptides for Crk and CrkL which disrupt Crk-complexes with DOCK180, SOS, and C3G. Oncogene. 1998;16: 1903.
21. Senechal K, Halpern J, Sawyers CL. The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. J Biol Chem. 1996;271:23,255.
22. Tanaka S, Ouchi T, Hanafusa H. Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G. Proc Natl Acad Sci U S A. 1997;94:2356.
23. Zhu T, Goh EL, LeRoith D, Lobie PE. Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII: resultant activation of c-Jun N- terminal kinase/ stress-activated protein kinase (JNK/SAPK). J Biol Chem. 1998;273:33,864.
24. Dolfi F, Garcia-Guzman M, Ojaniemi M, Nakamura H, Matsuda M, Vuori K. The adaptor protein crk connects multiple cellular stimuli to the JNK signaling pathway. Proc Natl Acad Sci U S A. 1998;95:15,394.
25. Shi C-S, Tuscano J, Witte W, Kehrl JH. GCKR links the Bcr-Abl oncogene and Ras to the stress activated protein kinase pathway. Blood. 1999;93: 1338.
26. Greulich H, Hanafusa H. A role for Ras in v-Crk transformation. Cell Growth Differ. 1996;7:1443.
27. Parrizas M, Blakesley VA, Bietner-Johnson D, LeRoith D. The protooncogene Crk-II enhances apoptosis by a ras-dependent, Raf-1/MAP kinase-independent pathway. Biochem Biophys Res Comm. 1997;234:616.
28. Tanaka S, Hanafusa H. Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism: JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases. J Biol Chem. 1998;273:1281.
29. Ezoe K, Lee ST, Strunk KM, Spritz RA. PTK1, a novel protein kinase required for proliferation of human melanocytes. Oncogene. 1994;9:935.
30. Ing YL, Leung IW, Heng HH, Tsui LC, Lassam NJ. MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. Oncogene. 1994;9: 1745.
31. Tibbles LA, Ing YL, Kiefer F, et al. MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J. 1996;24:7026.
32. Hirai S, Katoh M, Terada M, et al. MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem. 1997;272:15,167.
33. Leung IWL, Lassan N. Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase, MLK-3. J Biol Chem. 1998;273:32,408.
34. Yuasa T, Ohno S, Kehrl JH, Kyriakis JM. Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38: germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase upstream of MKK6 and p38. J Biol Chem. 1998;273:22,681.