Rock2 regulates Cdc25A through ubiquitin proteasome system in hepatocellular carcinoma cells

Experimental Cell Research

Volumn 318, Issue 16, 2012, Pages 1994-2003

  Liu, Tiande ^a   Yu, Xin ^a   Li, Guohui ^a   Yuan, Rongfa ^a   Wang, Qingnuo ^a   Tang, Ping ^a   Wu, Linquan ^a   Liu, Xiuxia ^b   Peng, Xiaogang ^b   Shao, Jianghua ^a,b  

^a NANCHANG UNIVERSITY   (China)

^b Jiangxi Province Key Laboratory of Molecular Medicine   (China)

Author keywords

Cdc25A; Hepatocellular carcinoma; Rock2; Ubiquitination

Indexed keywords

CDC25A PROTEIN; DNA; MESSENGER RNA; PROTEASOME; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RHO ASSOCIATED COILED COIL CONTAINING PROTEIN KINASE 2; RHO KINASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CELL CYCLE; CELL CYCLE REGULATION; CELL GROWTH; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME BINDING; ENZYME DEGRADATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; S PHASE CELL CYCLE CHECKPOINT; UBIQUITINATION; UPREGULATION;

EID: 84864302562     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.04.017     Document Type: Article

References (26)

1. Llovet J.M., Bruix J. Novel advancements in the management of hepatocellular carcinoma in 2008. J. Hepatol. 2008, 48:S20-S37.
2. Matsui T., Amano M., Yamamoto T., Chihara K., Nakafuku M., Ito M., Nakano T., Okawa K., Iwamatsu A., Kaibuchi K. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J. 1996, 15:2208-2216.
3. Riento K., Ridley A.J. Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell Biol. 2003, 4:445-456.
4. Wong C.C., Wong C.M., Tung E.K., Man K., Ng I.O. Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion. Hepatology 2009, 49:1583-1594.
5. Shi J., Wei L. Rho kinase in the regulation of cell death and survival. Arch. Immunol. Ther. Exp. (Warsz) 2007, 55:61-75.
6. Boutros R., Dozier C., Ducommun B. The when and whereas of CDC25 phosphatases. Curr. Opin. Cell Biol. 2006, 18:185-191.
7. Mailand N., Falck J., Lukas C., Syljuâsen R.G., Welcker M., Bartek J., Lukas J. Rapid destruction of human Cdc25A in response to DNA damage. Science 2000, 288:1425-1429.
8. Xu X., Yamamoto H., Sakon M., Yasui M., Ngan C.Y., Fukunaga H., Morita T., Ogawa M., Nagano H., Nakamori S., Sekimoto M., Matsuura N., Monden M. Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas. Clin. Cancer Res. 2003, 9:1764-1772.
9. Pereg Y., Liu B.Y., O'Rourke K.M., Sagolla M., Dey A., Komuves L., French D.M., Dixit V.M. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. Nat. Cell Biol. 2010, 12:400-406.
10. Neganova I., Vilella F., Atkinson S.P., Lloret M., Passos J.F., von Zglinicki T., O'Connor J.E., Burks D., Jones R., Armstrong L., Lako M. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic. Stem Cells 2011, 29:651-659.
11. Branzei D., Foiani M. Maintaining genome stability at the replication fork. Nat. Rev. Mol. Cell Biol. 2010, 11:208-219.
12. Broderick R., Nasheuer H.P. Regulation of Cdc45 in the cell cycle and after DNA damage. Biochem. Soc. Trans. 2009, 37:926-930.
13. Jin J., Ang X.L., Ye X., Livingstone M., Harper J.W. Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase. J. Biol. Chem. 2008, 283:19322-19328.
14. Wang P., Zou F., Zhang X., Li H., Dulak A., Tomko.R.J., Lazo J.S., Wang Z., Zhang L., Yu J. microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res. 2009, 69:8157-8165.
15. Sexl V., Diehl J.A., Sherr C.J., Ashmun R., Beach D., Roussel M.F. A rate limiting function of Cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene 1999, 18:573-582.
16. Shao J., Fujiwara T., Kadowaki Y., Fukazawa T., Waku T., Itoshima T., Yamatsuji T., Nishizaki M., Roth J.A., Tanaka N. Overexpression of the wild-type p53 gene inhibits NF-kB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells. Oncogene 2000, 19:726-736.
17. Beck H., Nähse V., Larsen M.S., Groth P., Clancy T., Lees M., Jørgensen M., Helleday T., Syljuåsen R.G., Sørensen C.S. Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J. Cell Biol. 2010, 188:629-638.
18. Reinhardt H.C., Yaffe M.B. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr. Opin. Cell Biol. 2009, 21:245-255.
19. Bartek J., Bartkova J., Lukas J. DNA damage signalling guards against activated oncogenes and tumor progression. Oncogene 2007, 26:7773-7779.
20. Ferguson R.L., Maller J.L. Centrosomal localization of Cyclin E-Cdk2 is required for initiation of DNA synthesis. Curr. Biol. 2010, 20:856-860.
21. Palou G., Palou R., Guerra-Moreno A., Duch A., Travesa A., Quintana D.G. Cyclin regulation by the S phase checkpoint. J. Biol. Chem. 2010, 285:26431-26440.
22. Bauer P.O., Wong H.K., Oyama F., Goswami A., Okuno M., Kino Y., Miyazaki H., Nukina N. Inhibition of Rho kinases enhances the degradation of mutant huntingtin. J. Biol. Chem. 2009, 284:13153-13164.
23. Boutros R., Lobjois V., Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets?. Nat. Rev. Cancer 2007, 7:495-507.
24. Joshi B., Strugnell S.S., Goetz J.G., Kojic L.D., Cox M.E., Griffith O.L., Chan S.K., Jones S.J., Leung S.P., Masoudi H., Leung S., Wiseman S.M., Nabi I.R. Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. Cancer Res. 2008, 68:8210-8220.
25. Marinissen M.J., Chiariello M., Tanos T., Bernard O., Narumiya S., Gutkind J.S. The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol. Cell 2004, 14:29-41.
26. Burdak-Rothkamm S., Rothkamm K., Prise K.M. ATM acts downstream of ATR in the DNA damage response signaling of bystander cells. Cancer Res. 2008, 68:7059-7065.