Regulation of Cdc45 in the cell cycle and after DNA damage

Biochemical Society Transactions

Volumn 37, Issue 4, 2009, Pages 926-930

  Broderick, Ronan ^a   Nasheuer, Heinz Peter ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Cdc45; Cell cycle; Checkpoint; DNA damage; DNA replication; Genome stability

Indexed keywords

(BENZO[A]PYRENE DIHYDRODIOL EPOXIDE); ATM PROTEIN; ATR PROTEIN; CARCINOGEN; CELL CYCLE PROTEIN; CELL DIVISION CYCLE 45 PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CHECKPOINT KINASE RAD3; GENOMIC DNA; HELICASE; MINICHROMOSOME MAINTENANCE PROTEIN 2; MINICHROMOSOME MAINTENANCE PROTEIN 7; OKAZAKI FRAGMENT; UNCLASSIFIED DRUG; CDC45L PROTEIN, HUMAN;

APOPTOSIS; CELL CYCLE ARREST; CELL CYCLE PHASE; CELL CYCLE REGULATION; CELL ELONGATION; COMPLEX FORMATION; CONFERENCE PAPER; DNA DAMAGE; DNA REPLICATION; EUKARYOTIC CELL; MINICHROMOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION; ANIMAL; BIOLOGICAL MODEL; CELL CYCLE; GENE EXPRESSION REGULATION; GENETICS; GENOMIC INSTABILITY; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

EUKARYOTA;

ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; DNA DAMAGE; DNA REPLICATION; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; HUMANS; MODELS, BIOLOGICAL;

EID: 70349304953     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0370926     Document Type: Conference Paper

References (38)

1. Hoeijmakers, J.H.J. (2001) Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374
2. Takeda, D.Y. and Dutta, A. (2005) DNA replication and progression through S phase. Oncogene 24, 2827-2843
3. Chattopadhyay, S. and Bielinsky, A.K. (2007) Human Mcm10 regulates the catalytic subunit of DNA polymerase-a and prevents DNA damage during replication. Mol. Biol. Cell 18, 4085-4095
4. Zhu, W., Ukomadu, C., Jha, S., Senga, T., Dhar, S.K., Wohlschlegel, J.A., Nutt, L.K., Kornbluth, S. and Dutta, A. (2007) Mcm10 and And-1/ CTF4 recruit DNA polymerase α to chromatin for initiation of DNA replication. Genes Dev. 21, 2288-2299
5. Bauerschmidt, C., Pollok, S., Kremmer, E., Nasheuer, H.P. and Grosse, F. (2007) Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases d and e during S phase. Genes Cells 12, 745-758
6. Blow, J.J. and Dutta, A. (2005) Preventing re-replication of chromosomal DNA. Nat. Rev. Mol. Cell Biol. 6, 476-486
7. Machida, Y.J., Hamlin, J.L. and Dutta, A. (2005) Right place, right time, and only once: replication initiation in metazoans. Cell 123, 13-24
8. Nasheuer, H.P., Smith, R., Bauerschmidt, C., Grosse, F. and Weisshart, K. (2002) Initiation of eukaryotic DNA replication: regulation and mechanisms. Prog. Nucleic Acid Res. Mol. Biol. 72, 41-94
9. Nasheuer, H.P., Pospiech, H. and Syvaoja, J. (2006) Progress towards the anatomy of the eukaryotic DNA replication fork. in DNA Polymerases: Encyclopaedic Reference of Genomics and Proteomics in Molecular Medicine (Ganten, D. and Ruckpaul, K.E., eds), pp. 27-68, Springer Verlag, Berlin
10. Hardy, C.F.J. (1997) Identification of Cdc45p, an essential factor required for DNA replication. Gene 187, 239-246
11. Masuda, T., Mimura, S. and Takisawa, H. (2003) CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45. Genes Cells 8, 145-161
12. Pollock. S., Stoepel, J., Bauerschmidt, C., Kremmer, E. and Nasheuer, H.-P. (2003) Regulation of eukaryotic DNA replication at the initiation step. Biochem. Soc. Trans. 31, 266-269
13. Moyer, S.E., Lewis, P.W. and and Botchan, M.R. (2006) Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc. Natl. Acad. Sci. U.S.A. 103, 10236-10241
14. Kamimura, Y., Tak, Y.S., Sugino, A. and Araki, H. (2001) Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J. 20, 2097-2107
15. Zou, L. and Stillman, B. (2000) Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol. Cell. Biol. 20, 3086-3096
16. Hopwood, B. and Dalton, S. (1996) Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication. Proc. Natl. Acad. Sci. U.S.A. 93, 12309-12314
17. Dalton, S. and Hopwood, B. (1997) Characterization of Cdc47p-minichromosome maintenance complexes in Saccharomyces cerevisiae: identification of Cdc45p as a subunit. Mol. Cell. Biol. 17, 5867-5875
18. Araki, Y., Kawasaki, Y., Sasanuma, H., Tye, B.K. and Sugino, A. (2003) Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability. Genes Cells 8, 465-480
19. Schmidt, U., Wollmann, Y., Franke, C., Grosse, F., Saluz, H.P. and Hänel, F. (2008) Characterization of the interaction between the human DNA topoisomerase IIβ-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein. Biochem. J. 409, 169-177
20. Kukimoto, I., Igaki, H. and Kanda, T. (1999) Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase α. Eur. J. Biochem. 265, 936-943
21. Bauerschmidt, C. (2006) Der humane Replikationsfaktor Cdc45: Lokalisation und Interaktionspartner Human, Ph.D, Thesis, Friedrich-Schiller-Universität, Jena, Germany
22. Akman, G. and MacNeill, S.A. (2009) MCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast. BMC Cell Biol. 10, 1-7
23. Bailis, J.M., Luche, D.D., Hunter, T. and Forsburg, S.L. (2008) Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote S-phase genome stability. Mol. Cell. Biol. 28, 1724-1738
24. Costa, A. and Onesti, S. (2008) The MCM complex: (just) a replicative helicase? Biochem. Soc. Trans. 36, 136-140
25. Bochman, M.L. Schwacha, A. (2008) The Mcm2-7 complex has in vitro helicase activity. Mol. Cell 31, 287-293
26. Forsburg, S.L. (2008) The MCM helicase: linking checkpoints to the replication fork. Biochem. Soc. Trans. 36, 114-119
27. Ibarra, A., Schwob, E. and Mendez, J. (2008) Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc. Natl. Acad. Sci. U.S.A. 105, 8956-8961
28. Sakakibara, N., Kasiviswanathan, R., Melamud, E., Han, M., Schwarz, F.P. and Kelman, Z. (2008) Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein. Nucleic Acids Res. 36, 1309-1320
29. 1 phase impairs MCM chromatin loading and inhibits DNA synthesis in mammalian cells. Cell Cycle 7, 2179-2188
30. You, Z. and Masai, H. (2008) Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity. J. Biol. Chem. 283, 24469-24477
31. Lévy, N., Oehlmann, M., Delalande, F., Nasheuer, H.P., Van Dorsselaer, A., Schreiber, V., de Murcia, G., Ménissier-de Murcia, J., Maiorano, D. and Bresson, A. (2009) XRCC1 interacts with the p58 subunit of DNA Pol a-primase and may coordinate DNA repair and replication during S phase. Nucleic Acids Res. 37, 3177-3188
32. Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.V.F., Kolettas, E., Niforou, K., Zoumpourlis, V.C. et al. (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444, 633-637
33. Di Micco, R., Fumagalli, M., Cicalese, A., Piccinin, S., Gasparini, P., Luise, C., Schurra, C., Garre, M., Nuciforo, P.G., Bensimon, A. et al. (2006) Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444, 638-642
34. Zhou, B.B.S. and Elledge, S.J. (2000) The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439
35. Kaufmann, W.K. (2007) Initiating the uninitiated: replication of damaged DNA and carcinogenesis. Cell Cycle 6, 1460-1467
36. Liu, P., Barkley, L.R., Day, T., Bi, X., Slater, D.M., Alexandrow, M.G., Nasheuer, H.P. and Vaziri, C. (2006) The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/CDK2-independent mechanism. J. Biol. Chem. 281, 30631-30644
37. Watanabe, K., Tateishi, S., Kawasuji, M., Tsurimoto, T., Inoue, H. and Yamaizumi, M, (2004) Rad18 guides pol& to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J. 23, 3886-3896
38. Pollock, S. and Grosse, F. (2007) Cdc45 degradation during differentiation and apoptosis. Biochem. Biophys. Res. Commun. 362, 910-915