An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells

Stem Cells

Volumn 29, Issue 4, 2011, Pages 651-659

  Neganova, Irina ^a,b   Vilella, Felipe ^b   Atkinson, Stuart P ^a,b   Lloret, Maria ^b   Passos, João F ^c   Von Zglinicki, Thomas ^c   O'Connor, José Enrique ^b   Burks, Deborah ^b   Jones, Richard ^d   Armstrong, Lyle ^a,b   Lako, Majlinda ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d MS BIOWORKS   (United States)

Author keywords

Apoptosis; Ataxia telangiectasia mutated; CHK2; Cyclin dependent kinase 2; DNA damage; G1 checkpoint; Human embryonic stem cells

Indexed keywords

ATM PROTEIN; BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; CELL DNA; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE 2; HISTONE H2AX; HISTONE H2AX GAMMA; PROTEIN P21; PROTEIN P27; PROTEIN P53; RAD52 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL NUCLEUS; CELL PROTECTION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE RESPONSE; DNA REPAIR; DNA REPLICATION; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; UPREGULATION;

APOPTOSIS; BRCA1 PROTEIN; CELL CYCLE PROTEINS; CELL LINE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; DOWN-REGULATION; EMBRYONIC STEM CELLS; G1 PHASE; GENE SILENCING; HISTONES; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MASS SPECTROMETRY; PROTEIN-SERINE-THREONINE KINASES; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; S PHASE; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 79953768222     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.620     Document Type: Article

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