Priceless GEMMs: Genetically engineered mouse models for colorectal cancer drug development

Trends in Pharmacological Sciences

Volumn 33, Issue 8, 2012, Pages 449-455

  Roper, Jatin ^a   Hung, Kenneth E ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CRE RECOMBINASE; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; RAPAMYCIN;

ANEMIA; APC GENE; BRAF GENE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL POPULATION; COLONOSCOPY; COLORECTAL CANCER; COMPUTER ASSISTED TOMOGRAPHY; CYP1A1 GENE; DRUG EFFICACY; DRUG RESEARCH; DRUG SCREENING; ENVIRONMENTAL FACTOR; GENE FREQUENCY; GENE FUNCTION; GENE MUTATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; IMAGING; IMMUNOMODULATION; IN VIVO STUDY; MUTAGENESIS; NONHUMAN; NONSENSE MUTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE; OPTICAL COHERENCE TOMOGRAPHY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; TRANSGENE; TRANSGENIC MOUSE; TRANSLATIONAL RESEARCH; TUMOR SUPPRESSOR GENE; TUMOR VOLUME; TUMOR XENOGRAFT; VILLIN GENE;

ANIMALS; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; HUMANS; MICE; MICE, TRANSGENIC;

EID: 84864277560     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.05.001     Document Type: Review

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