Complete deletion of Apc results in severe polyposis in mice

Oncogene

Volumn 29, Issue 12, 2010, Pages 1857-1864

  Cheung, A F ^a   Carter, A M ^a   Kostova, K K ^a   Woodruff, J F ^a   Crowley, D ^a   Bronson, R T ^b   Haigis, K M ^c   Jacks, T ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Apc null; Apc truncation; Colon cancer; Mouse model

Indexed keywords

APC PROTEIN; BETA CATENIN; GENE PRODUCT; WNT PROTEIN;

ALLELE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; APC GENE; ARTICLE; CELL COMPARTMENTALIZATION; CELL PROLIFERATION; COLON POLYPOSIS; COLORECTAL CANCER; DISEASE SEVERITY; FEMALE; GENE CLUSTER; GENE DELETION; GENE LOCATION; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; MALE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; BETA CATENIN; CODON; CODON, NONSENSE; DISEASE MODELS, ANIMAL; GENE DELETION; GENES, APC; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; INTESTINAL NEOPLASMS; MICE; MICE, INBRED C57BL; MULTIGENE FAMILY; MUTATION; PHENOTYPE;

MUS;

EID: 77950070097     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.457     Document Type: Article

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