Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs)

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 23, 2006, Pages 7898-7909

  Chen, Qiao Hong ^a   Praveen Rao, P N ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

3,4 Diaryl 2(5H)furanones; Anti inflammatory activity; Dual cyclooxygenase and lipoxygenase inhibitors; Oximes; Rofecoxib analogues

Indexed keywords

3 [4 (1 HYDROXYIMINO)ETHYLPHENYL] 4 (4 METHANESULFONYLPHENYL) 2(5H) FURANONE; 3 [4 (3 HYDROXYIMINOBUT 1 YNYL)PHENYL] 4 (4 METHANESULFONYLPHENYL) 2(5H) FURANONE; CAFFEIC ACID; CELECOXIB; LIPOXYGENASE INHIBITOR; NORDIHYDROGUAIARETIC ACID; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; EVALUATION; IC 50; NONHUMAN; PAW EDEMA; RAT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONATE 5-LIPOXYGENASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; LACTONES; LIPOXYGENASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 33750067066     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.047     Document Type: Article

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