VH replacement in mice and humans

Trends in Immunology

Volumn 28, Issue 3, 2007, Pages 132-137

  Zhang, Zhixin ^a  

^a The University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN LIGHT CHAIN; NUCLEAR PROTEIN; RAG 1 PROTEIN; RAG-1 PROTEIN; RAG2 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; B LYMPHOCYTE; CELL CLONE; CELL MATURATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC CODE; GENETIC RECOMBINATION; HEAVY CHAIN; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; LIGHT CHAIN; MOUSE; NONHUMAN; PROTEIN FUNCTION; REVIEW; ANIMAL; CHEMISTRY; GENETICS; PHYSIOLOGY;

ANIMALS; ANTIBODY DIVERSITY; B-LYMPHOCYTES; DNA-BINDING PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; NUCLEAR PROTEINS; RECOMBINATION, GENETIC;

EID: 33847160642     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2007.01.003     Document Type: Review

References (36)

1. Rajewsky K. Clonal selection and learning in the antibody system. Nature 381 (1996) 751-758
2. Tonegawa S. Somatic generation of antibody diversity. Nature 302 (1983) 575-581
3. Jung D., and Alt F.W. Unraveling V(D)J recombination: insights into gene regulation. Cell 116 (2004) 299-311
4. Jung D., et al. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu. Rev. Immunol. 24 (2006) 541-570
5. Schatz D.G., and Baltimore D. Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts. Cell 53 (1988) 107-115
6. Schatz D.G., et al. The V(D)J recombination activating gene. RAG-1. Cell 59 (1989) 1035-1048
7. Lewis S.M. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56 (1994) 27-150
8. Difilippantonio M.J., et al. RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination. Cell 87 (1996) 253-262
9. Ramsden D.A., et al. Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage. EMBO J. 15 (1996) 3197-3206
10. Casellas R., et al. Contribution of receptor editing to the antibody repertoire. Science 291 (2001) 1541-1544
11. Melamed D., and Nemazee D. Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 9267-9272
12. Melamed D., et al. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 92 (1998) 173-182
13. Sandel P.C., and Monroe J.G. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter. Immunity 10 (1999) 289-299
14. + B-cell lymphoma. Nature 322 (1986) 843-846
15. H joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature 322 (1986) 840-842
16. H heptamer. Int. Immunol. 2 (1990) 579-583
17. H replacement. Immunol. Rev. 197 (2004) 231-242
18. Chen C., et al. Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3 (1995) 747-755
19. Chen C., et al. The site and stage of anti-DNA B-cell deletion. Nature 373 (1995) 252-255
20. Lopez-Macias C., et al. Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses. J. Exp. Med. 189 (1999) 1791-1798
21. H-gene replacement. Eur. J. Immunol. 30 (2000) 2404-2411
22. Pewzner-Jung Y., et al. B cell deletion, anergy, and receptor editing in 'knock in' mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain. J. Immunol. 161 (1998) 4634-4645
23. Taki S., et al. Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Science 262 (1993) 1268-1271
24. H joining. Immunity 25 (2006) 43-53
25. H replacement rescues progenitor B cells with two nonproductive VDJ alleles. J. Immunol. 177 (2006) 7007-7014
26. +/+ mice. J. Immunol. 177 (2006) 1120-1128
27. Wang Y.H., et al. V(D)J recombinatorial repertoire diversification during intraclonal pro-B to B-cell differentiation. Blood 101 (2003) 1030-1037
28. H gene replacement to the primary B cell repertoire. Immunity 19 (2003) 21-31
29. H replacement in the peripheral repertoire was found on application of an improved algorithm, JointML, to 6329 human immunoglobulin H rearrangements. Immunology 119 (2006) 265-277
30. Liu Y., et al. Potential contribution of VH gene replacement in immunity and disease. Ann. N. Y. Acad. Sci. 1062 (2005) 175-181
31. Radic M.Z., et al. Residues that mediate DNA binding of autoimmune antibodies. J. Immunol. 150 (1993) 4966-4977
32. Radic M.Z., and Zouali M. Receptor editing, immune diversification and self-tolerance. Immunity 5 (1996) 505-511
33. Nunez C., et al. B cells are generated throughout life in humans. J. Immunol. 156 (1996) 866-872
34. Wardemann H., et al. Predominant autoantibody production by early human B cell precursors. Science 301 (2003) 1374-1377
35. Ueda Y., et al. Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. J. Exp. Med. 199 (2004) 47-58
36. Sims G.P., et al. Identification and characterization of circulating human transitional B cells. Blood 105 (2005) 4390-4398