Autoantibody selection and production in early human life

Journal of Clinical Investigation

Volumn 117, Issue 3, 2007, Pages 598-601

  Meffre, Eric ^a,b   Salmon, Jane E ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN M ANTIBODY;

ANTIBODY PRODUCTION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CELL MATURATION; FETUS CELL; HUMAN; HUMAN DEVELOPMENT; LIFE CYCLE; PRIORITY JOURNAL; REVIEW;

ANTIBODY FORMATION; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; B-LYMPHOCYTES; FEMALE; FETUS; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INFANT, NEWBORN; PARTURITION; UTERUS;

EID: 33847415482     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI31578     Document Type: Review

References (19)

1. Wardemann, H., et al. 2003. Predominant autoantibody production by early human B cell precursors. Science. 301:1374-1377.
2. Coutinho, A., Kazatchkine, M.D., and Avrameas, S. 1995. Natural autoantibodies. Curr. Opin. Immunol. 7:812-818.
3. Ichiyoshi, Y., and Casali, P. 1994. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. J. Exp. Med. 180:885-895.
4. Herzenberg, L.A., et al. 1986. The Ly-1 B cell lineage. Immunol. Rev. 93:81-102.
5. Hayakawa, K., et al. 1999. Positive selection of natural autoreactive B cells. Science. 285:113-116.
6. Merbl, Y., Zucker-Toledano, M., Quintana, F.J., and Cohen, I.R. 2007. Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics. J. Clin. Invest. 117:712-718. doi:10.1172/JCI29943.
7. Schroeder, H.W., et al. 1995. Developmental regulation of the human antibody repertoire. Ann. N. Y. Acad. Sci. 764:242-262.
8. Souto-Carneiro, M.M., Sims, G.P., Girschik, H., Lee, J., and Lipsky, P.E. 2005. Developmental changes in the human heavy chain CDR3. J. Immunol. 175:7425-7436.
9. Samuels, J., Ng, Y.-S., Coupillaud, C., Paget, D., and Meffre, E. 2005. Human B cell tolerance and its failure in rheumatoid arthritis. Ann. N. Y. Acad. Sci. 1062:116-126.
10. Ng, Y.-S., Wardemann, H., Chelnis, J., Cunningham-Rundles, C., and Meffre, E. 2004. Bruton's tyrosine kinase (Btk) is essential for human B cell tolerance. J. Exp. Med. 200:927-934.
11. Logtenberg, T., Young, F.M., van Es, J.H., Gmelig-Meyling, F.H., and Alt, F.W. 1989. Autoantibodies encoded by the most JH-proximal human immunoglobulin heavy chain variable region gene. J. Exp. Med. 170:1347-1355.
12. Ochsenbein, A.F., and Zinkernagel, R.M. 2000. Natural antibodies and complement link innate and acquired immunity. Immunol. Today. 21:624-630.
13. Pascual, V., et al. 1991. Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. J. Immunol. 146:4385-4391.
14. Zhang, M., et al. 2006. Identification of the target self-antigens in reperfusion injury. J. Exp. Med. 203:141-152.
15. Ray, S.K., Putterman, C., and Diamond, B. 1996. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc. Natl. Acad. Sci. U. S. A. 93:2019-2024.
16. Pugh-Bernard, A.E., et al. 2001. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J. Clin. Invest. 108:1061-1070. doi:10.1172/JCI200112462.
17. Van Vollenhoven, R.F., et al. 1999. VH4-34 encoded antibodies in systemic lupus erythematosus: a specific diagnostic marker that correlates with clinical disease characteristics. J. Rheumatol. 26:1727-1733.
18. Akira, S., Takeda, K., and Kaisho, T. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2:675-680.
19. Marshak-Rothstein, A. 2006. Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 6:823-835.