Actin Cytoskeleton Regulates Calcium Dynamics and NFAT Nuclear Duration

Molecular and Cellular Biology

Volumn 24, Issue 4, 2004, Pages 1628-1639

  Rivas, Fabiola V ^a   O'Keefe, James P ^a   Alegre, Maria Luisa ^a   Gajewski, Thomas F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; CD3 ANTIGEN; CYTOCHALASIN D; CYTOKINE; DNA BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE 3; INTERLEUKIN 2; IONOMYCIN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE ENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; PMCA1 PROTEIN; T LYMPHOCYTE RECEPTOR; THAPSIGARGIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NF AT; TRANSCRIPTION FACTOR NF-AT; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ACTIVE TRANSPORT; ANIMAL; ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CAPPING PHENOMENON; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSKELETON; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; HUMAN; HUMAN CELL; ION TRANSPORT; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

ACTINS; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CALCIUM; CALCIUM SIGNALING; CALCIUM-TRANSPORTING ATPASES; CATION TRANSPORT PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; CELL NUCLEUS; CYTOCHALASIN D; CYTOKINES; CYTOSKELETON; DNA-BINDING PROTEINS; GLYCOGEN SYNTHASE KINASE 3; INTERLEUKIN-2; ION TRANSPORT; MICE; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; RECEPTORS, ANTIGEN, T-CELL; TH1 CELLS; TH2 CELLS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0842325726     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.4.1628-1639.2004     Document Type: Article

References (41)

1. Abraham, C., and J. Miller. 2001. Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. J. Immunol. 167:5193-5201.
2. Acuto, O., and D. Cantrell. 2000. T cell activation and the cytoskeleton. Annu. Rev. Immunol. 18:165-184.
3. Balasubramanyam, M., and J. P. Gardner. 1995. Protein kinase C modulates cytosolic free calcium by stimulating calcium pump activity in Jurkat T cells. Cell Calcium 18:526-541.
4. Bautista, D. M., M. Hoth, and R. S. Lewis. 2002. Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T cells. J. Physiol. 541:877-894.
5. Bromley, S. K., W. R. Burack, K. G. Johnson, K. Somersalo, T. N. Sims, C. Sumen, M. M. Davis, A. S. Shaw, P. M. Allen, and M. L. Dustin. 2001. The immunological synapse. Annu. Rev. Immunol. 19:375-396.
6. Crabtree, G. R., and E. N. Olson. 2002. NFAT signaling: choreographing the social lives of cells. Cell 109(Suppl.):S67-S79.
7. 2+ response amplitude and duration. Nature 386:855-858.
8. Dolmetsch, R. E., K. Xu, and R. S. Lewis. 1998. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392:933-936.
9. Dong, C., D. D. Yang, M. Wysk, A. J. Whitmarsh, R. J. Davis, and R. A. Flavell. 1998. Defective T cell differentiation in the absence of Jnk1. Science 282:2092-2095.
10. 2+ pump is controlled by alternative splicing. J. Biol. Chem. 269:41-43.
11. Fields, P. E., and T. F. Gajewski. 2000. Biochemical analysis of activated T lymphocytes. Protein phosphorylation and Ras, ERK, and JNK activation. Methods Mol. Biol. 134:307-317.
12. Fischer, K. D., Y. Y. Kong, H. Nishina, K. Tedford, L. E. Marengere, I. Kozieradzki, T. Sasaki, M. Starr, G. Chan, S. Gardener, M. P. Nghiem, D. Bouchard, M. Barbacid, A. Bernstein, and J. M. Penninger. 1998. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol. 8:554-562.
13. + thymocytes. Nature 374:474-477.
14. Freiberg, B. A., H. Kupfer, W. Maslanik, J. Delli, J. Kappler, D. M. Zaller, and A. Kupfer. 2002. Staging and resetting T cell activation in SMACs. Nat. Immunol. 3:911-917.
15. Gajewski, T. F., P. Fields, and F. W. Fitch. 1995. Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A. Eur. J. Immunol. 25:1836-1842.
16. Gajewski, T. F., D. W. Lancki, R. Stack, and F. W. Fitch. 1994. "Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype. J. Exp. Med. 179:481-491.
17. Gajewski, T. F., M. Pinnas, T. Wong, and F. W. Fitch. 1991. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 146:1750-1758.
18. Grakoui, A., S. K. Bromley, C. Sumen, M. M. Davis, A. S. Shaw, P. M. Allen, and M. L. Dustin. 1999. The immunological synapse: a molecular machine controlling T cell activation. Science 285:221-227.
19. Gunzer, M., A. Schafer, S. Borgmann, S. Grabbe, K. S. Zanker, E. B. Brocker, E. Kampgen, and P. Friedl. 2000. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13:323-332.
20. Harder, T., and K. Simons. 1999. Clusters of glycolipid and glycosylphos-phatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol. 29:556-562.
21. Healy, J. I., R. E. Dolmetsch, L. A. Timmerman, J. G. Cyster, M. L. Thomas, G. R. Crabtree, R. S. Lewis, and C. C. Goodnow. 1997. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 6:419-428.
22. Holsinger, L. J., I. A. Graef, W. Swat, T. Chi, D. M. Bautista, L. Davidson, R. S. Lewis, F. W. Alt, and G. R. Crabtree. 1998. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr. Biol. 8:563-572.
23. Krawczyk, C., A. Oliveira-dos-Santos, T. Sasaki, E. Griffiths, P. S. Ohashi, S. Snapper, F. Alt, and J. M. Penninger. 2002. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16:331-343.
24. Lee, K. H., A. D. Holdorf, M. L. Dustin, A. C. Chan, P. M. Allen, and A. S. Shaw. 2002. T cell receptor signaling precedes immunological synapse formation. Science 295:1539-1542.
25. Lewis, R. S. 2001. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 19:497-521.
26. Liu, Z. G., H. Hsu, D. V. Goeddel, and M. Karin. 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565-576.
27. Macian, F., F. Garcia-Cozar, S. H. Im, H. F. Horton, M. C. Byrne, and A. Rao. 2002. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109:719-731.
28. Morgan, M. M., C. M. Labno, G. A. Van Seventer, M. F. Denny, D. B. Straus, and J. K. Burkhardt. 2001. Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70. J. Immunol. 167:5708-5718.
29. Penninger, J. M., and G. R. Crabtree. 1999. The actin cytoskeleton and lymphocyte activation. Cell 96:9-12.
30. Rivas, F. V., S. O'Herrin, and T. F. Gajewski. 2001. CD28 is not required for c-Jun N-terminal kinase activation in T cells. J. Immunol. 167:3123-3128.
31. Sedwick, C. E., M. M. Morgan, L. Jusino, J. L. Cannon, J. Miller, and J. K. Burkhardt. 1999. TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization. J. Immunol. 162:1367-1375.
32. Smith, J. A., Q. Tang, and J. A. Bluestone. 1998. Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets. J. Immunol. 160:4841-4849.
33. Snapper, S. B., F. S. Rosen, E. Mizoguchi, P. Cohen, W. Khan, C. H. Liu, T. L. Hagemann, S. P. Kwan, R. Ferrini, L. Davidson, A. K. Bhan, and F. W. Alt. 1998. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 9:81-91.
34. L-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein. J. Biol. Chem. 277:4351-4360.
35. Tarakhovsky, A., M. Turner, S. Schaal, P. J. Mee, L. P. Duddy, K. Rajewsky, and V. L. Tybulewicz. 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374:467-470.
36. Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181:577-584.
37. Viola, A., S. Schroeder, Y. Sakakibara, and A. Lanzavecchia. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283:680-682.
38. Wulfing, C., A. Bauch, G. R. Crabtree, and M. M. Davis. 2000. The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface. Proc. Natl. Acad. Sci. USA 97:10150-10155.
39. Wulfing, C., and M. M. Davis. 1998. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 282:2266-2269.
40. Zhang, R., F. W. Alt, L. Davidson, S. H. Orkin, and W. Swat. 1995. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470-473.
41. Zuckerman, L. A., A. J. Sant, and J. Miller. 1995. Identification of a unique costimulatory activity for murine T helper 1 T cell clones. J. Immunol. 154:4503-4512.