Ethylene bisdithiocarbamate pesticides cause cytotoxicity in transformed and normal human colon cells

Environmental Toxicology and Pharmacology

Volumn 34, Issue 2, 2012, Pages 556-573

  Hoffman, Lisa ^a   Hardej, Diane ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

Colon cells; Fungicides; Mancozeb; Maneb; Manganese; Zineb

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; MANCOZEB; MANEB; MANGANESE CHLORIDE; ZINC CHLORIDE; ZINEB; CASPASE; CHLORIDE; FUNGICIDE; MANGANESE; MANGANESE DERIVATIVE; ZINC; ZINC DERIVATIVE; CASPASE 3/7; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN; CELL STRAIN CACO 2; CELL STRAIN CCD 18CO; CELL STRAIN HT29; CELL TRANSFORMATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; INTESTINE CELL; LIPID PEROXIDATION; LONG TERM EXPOSURE; MICROSCOPY; PRIORITY JOURNAL; CELL LINE; CELL SURVIVAL; DRUG EFFECT; METABOLISM; CELL COUNT; CELL STRAIN HT 29; COLON CELL; EXPOSURE; IN VITRO STUDY;

CACO-2 CELLS; CASPASES; CELL LINE; CELL SURVIVAL; CHLORIDES; FUNGICIDES, INDUSTRIAL; HT29 CELLS; HUMANS; LIPID PEROXIDATION; MANEB; MANGANESE; MANGANESE COMPOUNDS; ZINC; ZINC COMPOUNDS; ZINEB;

EID: 84864038607     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2012.06.015     Document Type: Article

References (66)

1. Acquavella, J., Doe, J., Tomenson, J., Chester, G., Cowell, J., Bloeman, L., 2003. Epidemiologic studies of occupational pesticide exposure and cancer: regulatory risk assessments and biologic plausibility. Ann. Epidemiol. 1, 1-7.
2. Ahmad, I., Shukla, S., Kumar, A., Singh, B., Patel, D., Pandey, H., Singh, C., 2010. Maneb and paraquat-induced modulation of toxicant responsive genes in the rat liver: comparison with polymorphonuclear leukocytes. Chem. Biol. Interact. 188, 566-579.
3. Aisha, A., Sahib, H., Abu-Salah, K., Darwis, Y., Majid, A., 2009. Cytotoxic and anti-angiogenic properties of the stem bark extract of Sandoricum koetjape. Int. J. Cancer. Suppl. 5, 105-114.
4. Astiz, M., Alaniz, M., Marra, C., 2009a. Antioxidant defense system in rat simultaneously intoxicated with agrochemicals. Environ. Toxicol. Pharmacol. 28, 465-473.
5. Astiz, M., Alaniz, M., Marra, C., 2009b. Effect of pesticides on cell survival in liver and brain rat tissues. Ecotoxicol. Environ. Saf. 72, 2025-2032.
6. Axelstad, M., Boberg, J., Nellemann, C., Kiersgaard, M., Jacobsen, P., Christiansen, S., Hougaard, K., Hass, U., 2011. Exposure to the widely used fungicide mancozeb causes thyroid hormone disruption in rat dams but no behavioral effects in the offspring. Toxicol. Sci. 120, 439-446.
7. Barlow, B., Lee, D., Slechta, D., Opanashuk, L., 2005. Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells. Neurotoxicology 26, 63-75.
8. Belpoggi, F., Soffritti, M., Guarino, M., Lambertini, L., Cevolani, D., Maltoni, C., 2002. Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (Mancozeb) in rats. Ann. N.Y. Acad. Sci. 982, 123-136.
9. Boatright, K., Salvesen, G., 2003. Mechanisms of caspase activation. Curr. Opin. Cell Biol. 15, 725-731.
10. Brand, R., Cetin, Y., Mueller, C., Cuppett, S., 2005. Effect of fatty acids on herbicide transport across Caco-2 cell monolayers. Toxicol. In Vitro 19, 595-601.
11. Caldas, E., Miranda, M., Conceicao, M., de Souza, L., 2004. Dithiocarbamates residues in Brazilian food and the potential risk for consumers. Food Chem. Toxicol. 42, 1877-1883.
12. Calviello, G., Piccioni, E., Boninsegna, A., Tedecso, B., Maggiano, N., Serini, S., Wolf, F., Palozza, P., 2006. DNA damage and apoptosis induction by the pesticide mancozeb in rat cells: involvement of the oxidative mechanism. Toxicol. Appl. Pharmacol. 211, 87-96.
13. Cavret, S., Videmann, B., Mazallon, M., Lecoeur, S., 2005. Diazinon cytotoxicity and transfer in Caco-2 cells: effect of long-term exposure to the pesticide. Environ. Toxicol. Pharmacol. 20, 375-380.
14. Corsini, E., Birindelli, S., Fustinoni, S., De Paschale, G., Mammone, T., Visentin, S., Galli, C., Marinovich, M., Colosio, C., 2005. Immunomodulatory effects of the fungicide Mancozeb in agricultural workers. Toxicol. Appl. Pharmacol. 208, 178-185.
15. Corsini, E., Viviani, B., Birindelli, F., Gilardi, F., Torri, A., Codeca, I., Lucchi, L., Baresaghi, S., Galli, C., Marinovich, M., Colosio, C., 2006. Molecular mechanism underlying mancozeb-induced inhibition of TNF-alpha production. Toxicol. Appl. Pharmacol. 212, 89-98.
16. Cosentino, S., Gravaghi, C., Donetti, E., Donida, B., Lombardi, G., Bedoni, M., Fiorilli, A., Tettamanti, G., Ferraretto, A., 2010. Caseinphosphopeptide-induced calcium uptake in human intestinal cell lines HT-29 and Caco2 is correlated to cellular differentiation. J. Nutr. Biochem. 21, 247-254.
17. Domico, L., Zeevalk, Bernard, L., Cooper, K., 2006. Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction. Neurotoxicology 27, 816-825.
18. Domico, L., Cooper, K., Bernard, L., Zeevalk, G., 2007. Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its concentration to neuronal toxicity in mesencephalic cells. Neurotoxicology 28, 1079-1091.
19. Drechsel, D., Patel, M., 2008. Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease. Free Radic. Biol. Med. 44, 1873-1886.
20. Erikson, K., Aschner, M., 2003. Manganese neurotoxicity and glutamate-GABA interaction. Neurochem. Int. 43, 475-480.
21. European Commission, 2006. Monitoring of Pesticide Residues in Products of Plant Origin in the European Union, Norway, Iceland and Liechtenstein, 2006 Report. European Commission, Health and Consumer Protection Directorate-General Directorate F-Food and Veterinary Office.
22. Fei, Q., Ethell, D., 2008. Maneb potentiates Parquat neurotoxicity by inducing key Bcl-2 family members. J. Neurochem. 105, 2091-2097.
23. Fitsanakis, V., Amarnath, V., Moore, J., Montine, K., Zhang, J., Montine, T., 2002. Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides. Free Radic. Biol. Med. 33, 1714-1723.
24. Forgue-Lafitte, M., Coudray, A., Breant, B., Mester, J., 1989. Proliferation of the human colon carcinoma cell line HT29: autocrine growth and deregulated expression of the c-myc oncogene. Cancer Res. 49, 6566-6571.
25. Fraga, C.G., Leibovitz, B.E., Tappel, A.L., 1988. Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes. Free Radic. Biol. Med. 4, 155-161.
26. Fulda, S., 2009. Caspase-8 in cancer biology and therapy. Cancer Lett. 281, 128-133.
27. Goldner, W.S., Sandler, D.P., Yu, F., Hoppin, J.A., Kamel, F., Levan, T.D., 2010. Pesticide use and thyroid disease among women in the Agricultural Health Study. Am. J. Epidemiol. 171, 455-464.
28. Grosicka-Maciag, E., Kurpios-Piec, D., Szumiło, M., Grzela, T., Rahden-Staron, I., 2011. Protective effect of N-acetyl-l-cysteine against maneb induced oxidative and apoptotic injury in Chinese hamster V79 cells. Food Chem. Toxicol. 49, 1020-1025.
29. Hwang, E., Cash, J., Zabik, M., 2001. Postharvest treatments for the reduction of mancozeb in fresh apples. J. Agric. Food Chem. 49, 3127-3132.
30. Keikotlhaile, B., Spanoghe, P., Steurbaut, W., 2010. Effects of food processing on pesticide residues in fruits and vegetables: meta-analysis approach. Food Chem. Toxicol. 48, 1-6.
31. Kim, B., Choi, Y., Han, Y., Yun, Y., Hong, S., 2009. N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells. Toxicol. Appl. Pharmacol. 239, 87-97.
32. Kontou, S., Tsipi, D., Tzia, C., 2004. Stability of the dithiocarbamate pesticide maneb in tomato homogenates during cold storage and thermal processing. Food Addit. Contam. 21, 1083-1089.
33. Ksheerasagar, R., Kaliwal, B., 2003. Temporal effects of mancozeb on testes, accessory reproductive organs and biochemical constituents in albino mice. Environ. Toxicol. Pharmacol. 15, 9-17.
34. Kurttio, P., Vartiainen, T., Savolainen, K., 1990. Environmental and biological monitoring of exposure to ethylenebisdithiocarbamate fungicides and ethylenethiourea. Br. J. Ind. Med. 47, 203-206.
35. Leiphon, L., Picklo, M., 2007. Inhibition of aldehyde detoxification in CNS mitochondria by fungicides. Neurotoxicology 28, 143-149.
36. Lin, N., Garry, V.F., 2000. In vitro studies of cellular and molecular developmental toxicity of adjuvants, herbicides, and fungicides commonly used in Red River Valley, Minnesota. J. Toxicol. Environ. Health A 60, 423-439.
37. Meco, G., Bonifati, V., Vanacore, N., Fabrizio, E., 1994. Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). Scand. J. Work. Environ. Health 20, 301-305.
38. Medjdoub, A., Merzouk, S., Merzouk, H., Chiali, F., Narce, F., 2011. Effects of mancozeb and metribuzin on in vitro proliferative responses and oxidative stress of human and rat spleen lymphocytes stimulated by mitogens. Pestic. Biochem. Physiol. 101, 27-33.
39. Merhi, M., Demur, C., Racaud-Sultan, C., Bertrand, J., Canlet, C., Blas, F., Estrada, Y., Gamet-Payrastre, L., 2010. Gender-linked hematopoietic and metabolic disturbances induced by a pesticide mixture administered at low dose to mice. Toxicology 267, 80-90.
40. Milatovic, D., Gupta, R., Yu, Y., Zaja-Milatovic, S., Aschner, M., 2011. Protective effects of antioxidants and anti-inflammatory agents against manganese-induced oxidative damage and neuronal injury. Toxicol. Appl. Pharmacol. 256, 219-226.
41. Mosmann, T., 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
42. Navarro, E., Espinosa, L., Adell, T., Tora, M., Berrozpe, G., Real, F., 1999. Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements. Biochim. Biophys. Acta 1450, 254-264.
43. Nielsen, B., Larsen, E., Ladefoged, O., Lam, H., 2006. Neurotoxic effect of maneb in rats as studied by neurochemical and immunohistochemical parameters. Environ. Toxicol. Pharmacol. 21, 268-275.
44. Noratto, G., Kim, Y., Talcott, S., Mertens-Talcott, S., 2011. Flavonol-rich fractions of yaupon holly leaves (Ilex vomitoria Aquifoliaceae) induce microRNA-146a and have anti-inflammatory and chemopreventive effects in intestinal myofibroblast CCD-18Co cells. Fitoterapia 82, 557-569.
45. Nzengue, Y., Candéias, S., Sauvaigo, S., Douki, T., Favier, A., Rachidi, W., Pascale Guiraud, P., 2011. The toxicity redox mechanisms of cadmium alone or together with copper and zinc homeostasis alteration: its redox biomarkers. J. Trace Elem. Med. Biol. 25, 171-180.
46. Osaba, L., Rey, M., Aguirre, A., Alonso, A., Graf, U., 2002. Evaluation of genotoxicity of captan, maneb and zineb in the wing spot test of Drosophila melanogaster: role of nitrosation. Mutat. Res. 518, 95-106.
47. Patsakos, P., Liapis, K., Miliadis, G., Zafiriou, K., 1991. Mancozeb residues on field sprayed apricots. Bull. Environ. Contam. Toxicol. 48, 756-761.
48. Prabhakaran, K., Chapman, G., Gunasekar, P., 2009. BNIP3 up-regulation and mitochondrial dysfunction in manganese-induced neurotoxicity. Neurotoxicology 30, 414-422.
49. Qi, F., Li, A., Inagaki, Y., Xu, H., Wang, D., Cui, X., Zhang, L., Kokudo, N., Du, G., Tang, W., 2012. Induction of apoptosis by cinobufacini preparation through mitochondria-and Fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells. Food Chem. Toxicol. 50, 295-302.
50. Reuter, S., Eifes, S., Dicato, M., Aggarwal, B., Diederich, M., 2008. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem. Pharmacol. 76, 1340-1351.
51. Roede, J., Hansen, J., Go, Y., Jones, D., 2011. Maneb and Paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system. Toxicol. Sci. 121, 368-375.
52. Roy, S., Hardej, D., 2011. Tellurium tetrachloride and diphenyl ditelluride cause cyotoxicity in rat hippocampal astrocytes. Food Chem. Toxicol. 49, 2564-2574.
53. Solís-Vivanco, R., Rodríguez-Agudelo, Y., Riojas-Rodríguez, H., Ríos, C., Rosas, I., Montes, S., 2009. Cognitive impairment in an adult Mexican population non-occupationally exposed to manganese. Environ. Toxicol. Pharmacol. 28, 172-178.
54. Soloneski, S., Gonzalez, M., Piaggio, E., Reigosa, M., Larramendy, L., 2001. Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro III. Genotoxic evaluation on Chinese hamster ovary (CHO) cells. Mutat. Res. 514, 201-212.
55. Soloneski, S., Reigosa, M., Larramendy, L., 2003. Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro V. Abnormalities induced in the spindle apparatus of transformed and non-transformed mammalian cell lines. Mutat. Res. 536, 121-129.
56. Srivastava, A., Ali, W., Singh, R., Bhui, K., Tyagi, S., Al-Khedhairy, A., Srivastava, P., Musarrat, J., Shulka, Y., 2012. Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes. Life Sci. 90, 815-824.
57. Tilton, F., Du, J., Tanguay, R., 2008. Sulfhydryl systems are a critical factor in the zebrafish developmental toxicity of the dithiocarbamate sodium metam (NaM). Aquat. Toxicol. 90, 121-127.
58. Tirelli, V., Catone, T., Turco, L., Di Consiglio, E., Testai, E., De Angelis, I., 2007. Effects of the pesticide clorpyrifos on an in vitro model of intestinal barrier. Toxicol. In Vitro 21, 308-313.
59. Tsang, M., Trombetta, L., 2007. The protective role of chelators and antioxidants on mancozeb-induced toxicity in rat hippocampal astrocytes. Toxicol. Ind. Health 7, 459-470.
60. United States Geological Services, 2009. U.S. Statistics of EBDC Use (accessed 26.09.11) http://www.usgs.gov.
61. United States Environmental Protection Agency, 2010. Ethylene Bisdithiocarbamates (EBDCs) Maneb: Notice of Intent to Cancel Registration (accessed 24.10.10) http://www.epa.gov.
62. van Boxtel, A., Kamstra, J., Fluitsma, D., Legler, J., 2010. Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activity. Toxicol. Appl. Pharmacol. 244, 156-161.
63. Vidau, C., Brunet, J., Badiou, A., Belzunces, L., 2009. Phenylpyrazole insecticides induce cytotoxicity by altering mechanisms involved in cellular energy supply in the human epithelial cell model Caco-2. Toxicol. In Vitro 23, 589-597.
64. WHO, 1997. Pesticide Residues in Food-1997 Evaluations. Part II-Toxicology. International Programme on Chemical Safety. World Health Organization, Geneva, Switzerland.
65. Willman-Larhead, A., Artursson, P., 1995. Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco2) cells for studies of drug and peptide absorption. Eur. J. Pharm. Sci. 3, 171-183.
66. Zhou, Y., Shie, F., Piccardo, P., Montine, T., Zhang, J., 2004. Proteasomal inhibition induced by manganese ethylenebisdithiocarbmate: relevance to Parkinson's disease. Neuroscience 128, 281-291.