Induction of apoptosis by cinobufacini preparation through mitochondria- and Fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells

Food and Chemical Toxicology

Volumn 50, Issue 2, 2012, Pages 295-302

  Qi, Fanghua ^a,b   Li, Anyuan ^b   Inagaki, Yoshinori ^a   Xu, Huanli ^a   Wang, Dongliang ^a   Cui, Xiaoyan ^a   Zhang, Li ^c   Kokudo, Norihiro ^a   Du, Guanhua ^c   Tang, Wei ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Apoptosis; Caspase; Cinobufacini; Fas mediated apoptosis pathway; HCC cells; Mitochondria mediated apoptosis pathway

Indexed keywords

CASPASE 3; CASPASE 9; CINOBUFACINI; CYTOCHROME C; FAS ANTIGEN; NATURAL PRODUCT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CHINESE MEDICINE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SKIN GLAND; TOAD;

AMPHIBIAN VENOMS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BUFONIDAE; CASPASES; FAS LIGAND PROTEIN; HEP G2 CELLS; HUMANS; MEDICINE, CHINESE TRADITIONAL; MITOCHONDRIA; SKIN;

BUFO GARGARIZANS;

EID: 84855259405     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.10.040     Document Type: Article

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