메뉴 건너뛰기




Volumn 7, Issue 7, 2012, Pages

The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

EID: 84864009034     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041118     Document Type: Article
Times cited : (27)

References (72)
  • 1
    • 79953156769 scopus 로고    scopus 로고
    • Mitotic spindle misorientation in cancer - out of alignment and into the fire
    • Pease JC, Tirnauer JS, (2011) Mitotic spindle misorientation in cancer- out of alignment and into the fire. Journal of Cell Science 124: 1007-1016.
    • (2011) Journal of Cell Science , vol.124 , pp. 1007-1016
    • Pease, J.C.1    Tirnauer, J.S.2
  • 2
  • 3
    • 64049088018 scopus 로고    scopus 로고
    • Spindle orientation during asymmetric cell division
    • Siller KH, Doe CQ, (2009) Spindle orientation during asymmetric cell division. Nature Cell Biology 11: 365-374.
    • (2009) Nature Cell Biology , vol.11 , pp. 365-374
    • Siller, K.H.1    Doe, C.Q.2
  • 4
    • 79953293527 scopus 로고    scopus 로고
    • Par6B and Atypical PKC Regulate Mitotic Spindle Orientation during Epithelial Morphogenesis
    • Durgan J, Kaji N, Jin D, Hall A, (2011) Par6B and Atypical PKC Regulate Mitotic Spindle Orientation during Epithelial Morphogenesis. The Journal of Biological Chemistry 286: 12461-12474.
    • (2011) The Journal of Biological Chemistry , vol.286 , pp. 12461-12474
    • Durgan, J.1    Kaji, N.2    Jin, D.3    Hall, A.4
  • 5
    • 78049255724 scopus 로고    scopus 로고
    • Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins
    • Hao Y, Du Q, Chen X, Zheng Z, Balsbaugh JL, et al. (2010) Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. Current Biology 20: 1809-1818.
    • (2010) Current Biology , vol.20 , pp. 1809-1818
    • Hao, Y.1    Du, Q.2    Chen, X.3    Zheng, Z.4    Balsbaugh, J.L.5
  • 7
    • 77951174042 scopus 로고    scopus 로고
    • LGN regulates mitotic spindle orientation during epithelial morphogenesis
    • Zheng Z, Zhu H, Wan Q, Liu J, Xiao Z, et al. (2010) LGN regulates mitotic spindle orientation during epithelial morphogenesis. Journal of Cell Biology 189: 275-288.
    • (2010) Journal of Cell Biology , vol.189 , pp. 275-288
    • Zheng, Z.1    Zhu, H.2    Wan, Q.3    Liu, J.4    Xiao, Z.5
  • 9
    • 75349094518 scopus 로고    scopus 로고
    • Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue
    • Quyn AJ, Appleton PL, Carey FA, Steele RJ, Barker N, et al. (2010) Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell 6: 175-181.
    • (2010) Cell Stem Cell , vol.6 , pp. 175-181
    • Quyn, A.J.1    Appleton, P.L.2    Carey, F.A.3    Steele, R.J.4    Barker, N.5
  • 11
    • 69949106214 scopus 로고    scopus 로고
    • Cadherin Adhesion Receptors Orient the Mitotic Spindle during Symmetric Cell Division in Mammalian Epithelia
    • den Elzen N, Buttery CV, Maddugoda MP, Ren G, Yap AS, (2009) Cadherin Adhesion Receptors Orient the Mitotic Spindle during Symmetric Cell Division in Mammalian Epithelia. Molecular Biology of the Cell 20: 3740-3750.
    • (2009) Molecular Biology of the Cell , vol.20 , pp. 3740-3750
    • den Elzen, N.1    Buttery, C.V.2    Maddugoda, M.P.3    Ren, G.4    Yap, A.S.5
  • 12
    • 0032495530 scopus 로고    scopus 로고
    • A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
    • Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, et al. (1998) A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391: 184-187.
    • (1998) Nature , vol.391 , pp. 184-187
    • Hemminki, A.1    Markie, D.2    Tomlinson, I.3    Avizienyte, E.4    Roth, S.5
  • 13
    • 0032471851 scopus 로고    scopus 로고
    • Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
    • Mehenni H, Gehrig C, Nezu J, Oku A, Shimane M, et al. (1998) Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. American Journal of Human Genetics 63: 1641-1650.
    • (1998) American Journal of Human Genetics , vol.63 , pp. 1641-1650
    • Mehenni, H.1    Gehrig, C.2    Nezu, J.3    Oku, A.4    Shimane, M.5
  • 15
    • 67650898228 scopus 로고    scopus 로고
    • LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism
    • Jansen M, Klooster JPT, Offerhaus GJ, Clevers H, (2009) LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism. Physiology Reveiws 89: 777-798.
    • (2009) Physiology Reveiws , vol.89 , pp. 777-798
    • Jansen, M.1    Klooster, J.P.T.2    Offerhaus, G.J.3    Clevers, H.4
  • 17
    • 0032906537 scopus 로고    scopus 로고
    • Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer
    • Ylikorkala A, Avizienyte E, Tomlinson IP, Tiainen M, Roth S, et al. (1999) Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Human Molecular Genetics 8: 45-51.
    • (1999) Human Molecular Genetics , vol.8 , pp. 45-51
    • Ylikorkala, A.1    Avizienyte, E.2    Tomlinson, I.P.3    Tiainen, M.4    Roth, S.5
  • 18
    • 2542590883 scopus 로고    scopus 로고
    • Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene
    • Carretero J, Medina PP, Pio R, Montuenga LM, Sanchez-Cespedes M, (2004) Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 23: 4037-4040.
    • (2004) Oncogene , vol.23 , pp. 4037-4040
    • Carretero, J.1    Medina, P.P.2    Pio, R.3    Montuenga, L.M.4    Sanchez-Cespedes, M.5
  • 19
    • 25444524851 scopus 로고    scopus 로고
    • Mutations in the human LKB1/STK11 gene
    • Launonen V, (2005) Mutations in the human LKB1/STK11 gene. Human Mutation 26: 291-297.
    • (2005) Human Mutation , vol.26 , pp. 291-297
    • Launonen, V.1
  • 21
    • 0032984141 scopus 로고    scopus 로고
    • Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers
    • Su GH, Hruban RH, Bansal RK, Bova GS, Tang DJ, et al. (1999) Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. American Journal of Pathology 154: 1835-1840.
    • (1999) American Journal of Pathology , vol.154 , pp. 1835-1840
    • Su, G.H.1    Hruban, R.H.2    Bansal, R.K.3    Bova, G.S.4    Tang, D.J.5
  • 24
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, et al. (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Journal of BIology 2: 28.
    • (2003) Journal of BIology , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5
  • 25
    • 12144287284 scopus 로고    scopus 로고
    • LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    • Lizcano JM, Gorannson O, Toth R, Deak M, Morrice NA, et al. (2004) LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO Journal 23: 833-843.
    • (2004) EMBO Journal , vol.23 , pp. 833-843
    • Lizcano, J.M.1    Gorannson, O.2    Toth, R.3    Deak, M.4    Morrice, N.A.5
  • 26
    • 77949462458 scopus 로고    scopus 로고
    • AMPK as a metabolic tumor suppressor: control of metabolism and cell growth
    • Luo Z, Zang M, Guo W, (2010) AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncology 6: 457-470.
    • (2010) Future Oncology , vol.6 , pp. 457-470
    • Luo, Z.1    Zang, M.2    Guo, W.3
  • 27
    • 79953248896 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor suppression by LKB1
    • Vaahtomeri K, Makela TP, (2011) Molecular mechanisms of tumor suppression by LKB1. FEBS Letters 585: 944-951.
    • (2011) FEBS Letters , vol.585 , pp. 944-951
    • Vaahtomeri, K.1    Makela, T.P.2
  • 29
    • 33745213627 scopus 로고    scopus 로고
    • AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer
    • Motoshima H, Goldstein BJ, Igata M, Araki E, (2006) AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer. Journal of Physiology 574: 63-71.
    • (2006) Journal of Physiology , vol.574 , pp. 63-71
    • Motoshima, H.1    Goldstein, B.J.2    Igata, M.3    Araki, E.4
  • 30
    • 2942729619 scopus 로고    scopus 로고
    • LBK1 tumor suppressor protein: PARtaker in cell polarity
    • Baas AF, Smit L, Clevers H, (2004) LBK1 tumor suppressor protein: PARtaker in cell polarity. Trends in Cell Biology 14: 312-319.
    • (2004) Trends in Cell Biology , vol.14 , pp. 312-319
    • Baas, A.F.1    Smit, L.2    Clevers, H.3
  • 31
    • 41149117383 scopus 로고    scopus 로고
    • LKB1 and AMPK in cell polarity and division
    • Williams T, Brenman JE, (2008) LKB1 and AMPK in cell polarity and division. Trends in Cell Biology 18: 193-198.
    • (2008) Trends in Cell Biology , vol.18 , pp. 193-198
    • Williams, T.1    Brenman, J.E.2
  • 32
    • 0034090975 scopus 로고    scopus 로고
    • The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry
    • Watts JL, Morton DG, Bestman J, Kemphues KJ, (2000) The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development 127: 1467-1475.
    • (2000) Development , vol.127 , pp. 1467-1475
    • Watts, J.L.1    Morton, D.G.2    Bestman, J.3    Kemphues, K.J.4
  • 33
    • 0026773728 scopus 로고
    • par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis
    • Morton DG, Roos JM, Kemphues KJ, (1992) par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis. Genetics 130: 771-790.
    • (1992) Genetics , vol.130 , pp. 771-790
    • Morton, D.G.1    Roos, J.M.2    Kemphues, K.J.3
  • 34
    • 0037461735 scopus 로고    scopus 로고
    • A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
    • Martin SG, St Johnston D, (2003) A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421: 379-384.
    • (2003) Nature , vol.421 , pp. 379-384
    • Martin, S.G.1    St Johnston, D.2
  • 35
    • 0037089467 scopus 로고    scopus 로고
    • Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
    • Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, et al. (2002) Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Research 62: 2261-2266.
    • (2002) Cancer Research , vol.62 , pp. 2261-2266
    • Miyoshi, H.1    Nakau, M.2    Ishikawa, T.O.3    Seldin, M.F.4    Oshima, M.5
  • 38
    • 0037102428 scopus 로고    scopus 로고
    • Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
    • Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, et al. (2002) Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Research 62: 4549-4553.
    • (2002) Cancer Research , vol.62 , pp. 4549-4553
    • Nakau, M.1    Miyoshi, H.2    Seldin, M.F.3    Imamura, M.4    Oshima, M.5
  • 39
    • 0035903028 scopus 로고    scopus 로고
    • Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
    • Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, et al. (2001) Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 293: 1323-1326.
    • (2001) Science , vol.293 , pp. 1323-1326
    • Ylikorkala, A.1    Rossi, D.J.2    Korsisaari, N.3    Luukko, K.4    Alitalo, K.5
  • 40
    • 1542777034 scopus 로고    scopus 로고
    • Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD
    • Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, et al. (2004) Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD. Cell 116: 457-466.
    • (2004) Cell , vol.116 , pp. 457-466
    • Baas, A.F.1    Kuipers, J.2    van der Wel, N.N.3    Batlle, E.4    Koerten, H.K.5
  • 41
    • 77957735280 scopus 로고    scopus 로고
    • LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity
    • Xu X, Omelchenko T, Hall A, (2010) LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity. BMC Cell Biology 11: 77.
    • (2010) BMC Cell Biology , vol.11 , pp. 77
    • Xu, X.1    Omelchenko, T.2    Hall, A.3
  • 42
    • 34548179000 scopus 로고    scopus 로고
    • Suppression of Tubulin Polymerization by the LKB1-Microtubule-associated Protein/Microtubule Affinity-regulating Kinase Signaling
    • Kojima Y, Miyoshi H, Clevers HC, Oshima M, Aoki M, et al. (2007) Suppression of Tubulin Polymerization by the LKB1-Microtubule-associated Protein/Microtubule Affinity-regulating Kinase Signaling. Journal of Biological Chemistry 282: 23532-23540.
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 23532-23540
    • Kojima, Y.1    Miyoshi, H.2    Clevers, H.C.3    Oshima, M.4    Aoki, M.5
  • 43
    • 84856820958 scopus 로고    scopus 로고
    • LKB1 Destabilizes Microtubules in Myoblasts and Contributes to Myoblast Differentiation
    • Mian I, Pierre-Louis WS, Dole N, Gilberti RM, Dodge-Kafka K, et al. (2012) LKB1 Destabilizes Microtubules in Myoblasts and Contributes to Myoblast Differentiation. PLoS One 7: e31583.
    • (2012) PLoS One , vol.7
    • Mian, I.1    Pierre-Louis, W.S.2    Dole, N.3    Gilberti, R.M.4    Dodge-Kafka, K.5
  • 44
    • 0042090214 scopus 로고    scopus 로고
    • Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
    • Spicer J, Rayter S, Young N, Elliott R, Ashworth A, et al. (2003) Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene 22: 4752-4756.
    • (2003) Oncogene , vol.22 , pp. 4752-4756
    • Spicer, J.1    Rayter, S.2    Young, N.3    Elliott, R.4    Ashworth, A.5
  • 48
    • 72949115493 scopus 로고    scopus 로고
    • Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
    • Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM, (2009) Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science 326: 1707-1711.
    • (2009) Science , vol.326 , pp. 1707-1711
    • Zeqiraj, E.1    Filippi, B.M.2    Deak, M.3    Alessi, D.R.4    van Aalten, D.M.5
  • 49
    • 77953121697 scopus 로고    scopus 로고
    • AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation
    • Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, et al. (2010) AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nature Cell Biology 12: 583-590.
    • (2010) Nature Cell Biology , vol.12 , pp. 583-590
    • Nakano, A.1    Kato, H.2    Watanabe, T.3    Min, K.D.4    Yamazaki, S.5
  • 50
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada D, Saunders TL, Morrison SJ, (2010) Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468: 653-658.
    • (2010) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 51
    • 34250844968 scopus 로고    scopus 로고
    • The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division
    • Bonaccorsi S, Mottier V, Giansanti MG, Bolkan BJ, Williams B, et al. (2007) The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. Development 134: 2183-2193.
    • (2007) Development , vol.134 , pp. 2183-2193
    • Bonaccorsi, S.1    Mottier, V.2    Giansanti, M.G.3    Bolkan, B.J.4    Williams, B.5
  • 52
    • 36549040859 scopus 로고    scopus 로고
    • The selectivity of protein kinase inhibitors: a further update
    • Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, et al. (2007) The selectivity of protein kinase inhibitors: a further update. Biochem Journal 408: 297-315.
    • (2007) Biochem Journal , vol.408 , pp. 297-315
    • Bain, J.1    Plater, L.2    Elliott, M.3    Shpiro, N.4    Hastie, C.J.5
  • 53
    • 29244474612 scopus 로고    scopus 로고
    • Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
    • Wei C, Amos CI, Stephens LC, Campos I, Deng JM, et al. (2005) Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Research 65: 11297-11303.
    • (2005) Cancer Research , vol.65 , pp. 11297-11303
    • Wei, C.1    Amos, C.I.2    Stephens, L.C.3    Campos, I.4    Deng, J.M.5
  • 54
    • 0032893658 scopus 로고    scopus 로고
    • Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence
    • Wang ZJ, Ellis I, Zauber P, Iwama T, Marchese C, et al. (1999) Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. Journal of Pathology 188: 9-13.
    • (1999) Journal of Pathology , vol.188 , pp. 9-13
    • Wang, Z.J.1    Ellis, I.2    Zauber, P.3    Iwama, T.4    Marchese, C.5
  • 55
    • 0037068461 scopus 로고    scopus 로고
    • Loss of the Lkb2 tumour suppressor provokes intestinal polyposis but resistance to transformation
    • Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, et al. (2002) Loss of the Lkb2 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419: 162-167.
    • (2002) Nature , vol.419 , pp. 162-167
    • Bardeesy, N.1    Sinha, M.2    Hezel, A.F.3    Signoretti, S.4    Hathaway, N.A.5
  • 57
    • 0028101021 scopus 로고
    • Orientation of Spindle Axis and Distribution of Plasma Membrane Proteins During Cell Division in Polarized MDCKII Cells
    • Reinsch S, Karsenti E, (1994) Orientation of Spindle Axis and Distribution of Plasma Membrane Proteins During Cell Division in Polarized MDCKII Cells. The Journal of Cell Biology 126: 1509-1526.
    • (1994) The Journal of Cell Biology , vol.126 , pp. 1509-1526
    • Reinsch, S.1    Karsenti, E.2
  • 58
    • 32144450233 scopus 로고    scopus 로고
    • RNA interference techniques to study epithelial cell adhesion and polarity
    • Chen X, Macara IG, (2006) RNA interference techniques to study epithelial cell adhesion and polarity. Methods In Enzymology 406: 362-374.
    • (2006) Methods In Enzymology , vol.406 , pp. 362-374
    • Chen, X.1    Macara, I.G.2
  • 59
    • 0034253536 scopus 로고    scopus 로고
    • The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    • Joberty G, Petersen C, Gao L, Macara IG, (2000) The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nature Cell Biology 2: 531-539.
    • (2000) Nature Cell Biology , vol.2 , pp. 531-539
    • Joberty, G.1    Petersen, C.2    Gao, L.3    Macara, I.G.4
  • 60
    • 77952396762 scopus 로고    scopus 로고
    • Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation
    • Qin Y, Meisen WH, Hao Y, Macara IG, (2010) Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation. Journal of Cell Biology 189: 661-669.
    • (2010) Journal of Cell Biology , vol.189 , pp. 661-669
    • Qin, Y.1    Meisen, W.H.2    Hao, Y.3    Macara, I.G.4
  • 61
    • 68449094064 scopus 로고    scopus 로고
    • The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis
    • Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA, (2009) The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis. Cell Cycle 8: 2385-2398.
    • (2009) Cell Cycle , vol.8 , pp. 2385-2398
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Menendez, J.A.3
  • 63
    • 57349094302 scopus 로고    scopus 로고
    • AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism
    • Witczak CA, Sharoff CG, Goodyear LJ, (2008) AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism. Cellular and Molecular Life Sciences 65: 3737-3755.
    • (2008) Cellular and Molecular Life Sciences , vol.65 , pp. 3737-3755
    • Witczak, C.A.1    Sharoff, C.G.2    Goodyear, L.J.3
  • 64
    • 33751204464 scopus 로고    scopus 로고
    • AMP-activated protein kinase regulates the assembly of epithelial tight junctions
    • Zhang L, Li J, Young LH, Caplan MJ, (2006) AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci U S A 103: 17272-17277.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17272-17277
    • Zhang, L.1    Li, J.2    Young, L.H.3    Caplan, M.J.4
  • 65
    • 33846521353 scopus 로고    scopus 로고
    • Regulation of epithelial tight junction assembly and disassembly by AMPK-activated protein kinase
    • Zheng B, Cantley L, (2007) Regulation of epithelial tight junction assembly and disassembly by AMPK-activated protein kinase. Proc Natl Acad Sci U S A 104: 819-822.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 819-822
    • Zheng, B.1    Cantley, L.2
  • 70
    • 0037022122 scopus 로고    scopus 로고
    • Assembly of Epithelial Tight Junctions Is Negatively Regulated by Par6
    • Gao L, Joberty G, Macara IG, (2002) Assembly of Epithelial Tight Junctions Is Negatively Regulated by Par6. Current Biology 12: 221-225.
    • (2002) Current Biology , vol.12 , pp. 221-225
    • Gao, L.1    Joberty, G.2    Macara, I.G.3
  • 71
    • 0032514214 scopus 로고    scopus 로고
    • Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity
    • Jou TS, Nelson WJ, (1998) Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. Journal of Cell Biology 142: 85-100.
    • (1998) Journal of Cell Biology , vol.142 , pp. 85-100
    • Jou, T.S.1    Nelson, W.J.2
  • 72
    • 0035947235 scopus 로고    scopus 로고
    • A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle
    • Mu J, Brozinick JTJ, Valladares O, Bucan M, Birnbaum MJ, (2001) A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle. Molecular Cell 7: 1085-1094.
    • (2001) Molecular Cell , vol.7 , pp. 1085-1094
    • Mu, J.1    Brozinick, J.T.J.2    Valladares, O.3    Bucan, M.4    Birnbaum, M.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.