Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Garcia, Matthew ^a   Leonardi, Roberta ^a   Zhang, Yong Mei ^b   Rehg, Jerold E ^a   Jackowski, Suzanne ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ARACHIDONIC ACID; COENZYME A; DOCOSAHEXAENOIC ACID; KETONE; LINOLEIC ACID; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; PALMITOLEIC ACID; PANTOTHENATE KINASE; PANTOTHENATE KINASE 1; PANTOTHENATE KINASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEARIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ABNORMAL SUBSTRATE CONCENTRATION IN BLOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BRAIN LEVEL; COENZYME A BIOSYNTHESIS; COMPARATIVE STUDY; DISEASE SEVERITY; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GERM LINE; GERMLINE DELETION; GLUCONEOGENESIS; HYPERKETONEMIA; HYPOGLYCEMIA; KNOCKOUT MOUSE; LIPID COMPOSITION; LIPID LIVER LEVEL; LIPID STORAGE; LIVER CELL; METABOLISM; MOUSE; NEWBORN MORTALITY; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT;

ANIMALS; ANIMALS, NEWBORN; BRAIN; COENZYME A; FATTY ACIDS; GENE DELETION; GENE TARGETING; GERM CELLS; GLUCONEOGENESIS; HUMANS; KETONES; LIVER; MICE; MICE, KNOCKOUT; NAD; ORGAN SIZE; OXIDATION-REDUCTION; PHENOTYPE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RNA, MESSENGER; STEAROYL-COA DESATURASE; TRIGLYCERIDES;

MUS;

EID: 84864005176     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040871     Document Type: Article

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