Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration

EMBO Molecular Medicine

Volumn 3, Issue 12, 2011, Pages 755-766

  Siudeja, Katarzyna ^a   Srinivasan, Balaji ^a   Xu, Lanjun ^a,b   Rana, Anil ^a   de Jong, Jannie ^a   Nollen, Ellen A A ^a   Jackowski, Suzanne ^c   Sanford, Lynn ^d   Hayflick, Susan ^d   Sibon, Ody C M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

DNA damage; HDAC inhibitors; NBIA; PKAN; Protein acetylation

Indexed keywords

COENZYME A; HISTONE; PANTOTHENATE KINASE; TUBULIN;

ACETYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DROSOPHILA; ENZYME METABOLISM; HUMAN; HUMAN CELL; LOCOMOTION; NONHUMAN; PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION; PHENOTYPE; PRIORITY JOURNAL; SURVIVAL;

ACETYLATION; ANIMALS; COENZYME A; DISEASE MODELS, ANIMAL; DROSOPHILA; HISTONES; HUMANS; PANTETHEINE; PANTOTHENATE KINASE-ASSOCIATED NEURODEGENERATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; TUBULIN;

EID: 82955214822     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201100180     Document Type: Article

References (37)

1. Afshar K, Gonczy P, DiNardo S, Wasserman SA (2001) Fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster. Genetics 157: 1267- 1276
2. Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J (2010) MEC-17 is an alpha-tubulin acetyltransferase. Nature 467: 218- 222
3. Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, et al (2007) New nomenclature for chromatin-modifying enzymes. Cell 131: 633- 636
4. Biedler JL, Roffler-Tarlov S, Schachner M, Freedman LS (1978) Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res 38: 3751- 3757
5. Bosveld F, Rana A, van der Wouden PE, Lemstra W, Ritsema M, Kampinga HH, Sibon OC (2008) De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system. Hum Mol Genet 17: 2058- 2069
6. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71- 94
7. Chen CC, Carson JJ, Feser J, Tamburini B, Zabaronick S, Linger J, Tyler JK (2008) Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell 134: 231- 243
8. Cho Y, Griswold A, Campbell C, Min KT (2005) Individual histone deacetylases in Drosophila modulate transcription of distinct genes. Genomics 86: 606- 617
9. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325: 834- 840
10. Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, et al (2009) Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell 136: 551- 564
11. Das C, Lucia MS, Hansen KC, Tyler JK (2009) CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 459: 113- 117
12. Dompierre JP, Godin JD, Charrin BC, Cordelieres FP, King SJ, Humbert S, Saudou F (2007) Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J Neurosci 27: 3571- 3583
13. Fischer A, Sananbenesi F, Mungenast A, Tsai LH (2010) Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol Sci 31: 605- 617
14. Foglietti C, Filocamo G, Cundari E, De Rinaldis E, Lahm A, Cortese R, Steinkuhler C (2006) Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling. J Biol Chem 281: 17968- 17976
15. Gregory A, Polster BJ, Hayflick SJ (2009) Clinical and genetic delineation of neurodegeneration with brain iron accumulation. J Med Genet 46: 73- 80
16. Katyal S, McKinnon PJ (2008) DNA strand breaks, neurodegeneration and aging in the brain. Mech Ageing Dev 129: 483- 491
17. Kontopoulos E, Parvin JD, Feany MB (2006) Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet 15: 3012- 3023
18. Kruer MC, Hiken M, Gregory A, Malandrini A, Clark D, Hogarth P, Grafe M, Hayflick SJ, Woltjer RL (2011) Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration. Brain 134: 947- 958
19. Kurdistani SK, Grunstein M (2003) Histone acetylation and deacetylation in yeast. Nat Rev Mol Cell Biol 4: 276- 284
20. LeDizet M, Piperno G (1987) Identification of an acetylation site of Chlamydomonas alpha-tubulin. Proc Natl Acad Sci USA 84: 5720- 5724
21. Lee KK, Workman JL (2007) Histone acetyltransferase complexes: one size doesn't fit all. Nat Rev Mol Cell Biol 8: 284- 295
22. Leonardi R, Zhang YM, Rock CO, Jackowski S (2005) Coenzyme A: back in action. Prog Lipid Res 44: 125- 153
23. Monti B, Polazzi E, Contestabile A (2009) Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection. Curr Mol Pharmacol 2: 95- 109
24. Perdiz D, Mackeh R, Pous C, Baillet A (2011) The ins and outs of tubulin acetylation: More than just a post-translational modification? Cell Signal 23: 763- 771
25. Rana A, Seinen E, Siudeja K, Muntendam R, Srinivasan B, van der Want JJ, Hayflick S, Reijngoud DJ, Kayser O, Sibon OC (2010) Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration. Proc Natl Acad Sci USA 107: 6988- 6993
26. Saha SN, Pahan K (2006) HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis. Cell Death Differ 13: 539- 550
27. Shahbazian MD, Grunstein M (2007) Functions of site-specific histone acetylation and deacetylation. Annu Rev Biochem 76: 75- 100
28. Shida T, Cueva JG, Xu Z, Goodman MB, Nachury MV (2010) The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation. Proc Natl Acad Sci USA 107: 21517- 21522
29. Starai VJ, Takahashi H, Boeke JD, Escalante-Semerena JC (2004) A link between transcription and intermediary metabolism: a role for Sir2 in the control of acetyl-Coenzyme A synthetase. Curr Opin Microbiol 7: 115- 119
30. Takahashi H, McCaffery JM, Irizarry RA, Boeke JD (2006) Nucleocytosolic acetyl-Coenzyme A synthetase is required for histone acetylation and global transcription. Mol Cell 23: 207- 217
31. van Attikum H, Gasser SM (2005) The histone code at DNA breaks: A guide to repair? Nat Rev Mol Cell Biol 6: 757- 765
32. Vempati RK, Jayani RS, Notani D, Sengupta A, Galande S, Haldar D (2010) p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals. J Biol Chem 285: 28553- 28564
33. Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB (2009) ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324: 1076- 1080
34. Wu Z, Li C, Lv S, Zhou B (2009) Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model. Hum Mol Genet 18: 3659- 3672
35. Yuan J, Pu M, Zhang Z, Lou Z (2009) Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle 8: 1747- 1753
36. Zhang YM, Chohnan S, Virga KG, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Newgard CB, Lee RE, Rock CO, et al (2007) Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic Coenzyme A homeostasis. Chem Biol 14: 291- 302
37. Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick SJ (2001) A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Nat Genet 28: 345- 349