Chemical Knockout of Pantothenate Kinase Reveals the Metabolic and Genetic Program Responsible for Hepatic Coenzyme A Homeostasis

Chemistry and Biology

Volumn 14, Issue 3, 2007, Pages 291-302

  Zhang, Yong Mei ^a   Chohnan, Shigeru ^a   Virga, Kristopher G ^b   Stevens, Robert D ^c   Ilkayeva, Olga R ^c   Wenner, Brett R ^c   Bain, James R ^c   Newgard, Christopher B ^c   Lee, Richard E ^b   Rock, Charles O ^a   Jackowski, Suzanne ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

CHEMBIOL; DNA; SIGNALING

Indexed keywords

4 AMINOBUTYRIC ACID; CARNITINE; COENZYME A; DRUG DERIVATIVE; NOOTROPIC AGENT; PANTOGAB; PANTOTHENATE KINASE; PANTOTHENIC ACID; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; C57BL MOUSE; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; LIVER; METABOLISM; MOUSE; MOUSE MUTANT; SYNTHESIS;

ANIMALS; CARNITINE; COENZYME A; FEMALE; GAMMA-AMINOBUTYRIC ACID; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMEOSTASIS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NOOTROPIC AGENTS; PANTOTHENIC ACID; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

MUS;

EID: 33947241895     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2007.01.013     Document Type: Article

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