Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: Identification of a conditional mutation in the pantothenate kinase gene CAB1

Current Genetics

Volumn 55, Issue 2, 2009, Pages 163-173

  Olzhausen, Judith ^a   Schübbe, Sabrina ^a   Schüller, Hans Joachim ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Coenzyme A; Pantothenate; Pantothenate kinase; Saccharomyces cerevisiae

Indexed keywords

COENZYME A; COENZYME A BIOSYNTHESIS 1; FATTY ACID SYNTHASE; FUNGAL PROTEIN; PANTOTHENATE KINASE; UNCLASSIFIED DRUG;

CONTROLLED STUDY; ENZYME ACTIVITY; FUNGAL GENE; FUNGAL STRAIN; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENE STRUCTURE; GENETIC ANALYSIS; MISSENSE MUTATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS; TEMPERATURE SENSITIVITY;

AMINO ACID SEQUENCE; COENZYME A; GENE EXPRESSION REGULATION, FUNGAL; HYDROXYMETHYL AND FORMYL TRANSFERASES; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE SYNTHASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SYMPORTERS; TEMPERATURE;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 67349203977     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-009-0234-1     Document Type: Review

References (32)

1. Ben-Aroya S, Coombes C, Kwok T, O'Donnell KA, Boeke JD, Hieter P (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30:248-258
2. Bucovaz ET, Tarnowski SJ, Morrison WC, Macleod RM, Morrison JC, Sobhy CM, Rhoades JL, Fryer JE, Wakim JM, Whybrew WD (1980) Coenzyme A-synthesizing protein complex of Saccharomyces cerevisiae. Mol Cell Biochem 30:7-26
3. Bucovaz ET, Macleod RM, Morrison JC, Whybrew WD (1997) The coenzyme A-synthesizing protein complex and its proposed role in CoA biosynthesis in bakers' yeast. Biochimie 79:787-798
4. Calder RB, Williams RS, Ramaswamy G, Rock CO, Campbell E, Unkles SE, Kinghorn JR, Jackowski S (1999) Cloning and characterization of a eukaryotic pantothenate kinase gene (panK) from Aspergillus nidulans. J Biol Chem 274:2014-2020
5. Chen M, Hancock LC, Lopes JM (2007) Transcriptional regulation of yeast phospholipid biosynthetic genes. Biochim Biophys Acta 1771:310-321
6. Cronan JE Jr, Littel KJ, Jackowski S (1982) Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium. J Bacteriol 149:916-922
7. Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crécy-Lagard V, Osterman A (2002) Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J Biol Chem 277:21431-21439
8. de La Sierra-Gallay IL, Collinet B, Graille M, Quevillon-Cheruel S, Liger D, Minard P, Blondeau K, Henckes G, Aufrere R, Leulliot N, Zhou CZ, Sorel I, Ferrer JL, Poupon A, Janin J, van Tilbeurgh H (2004) Crystal structure of the YGR205w protein from Saccharomyces cerevisiae: close structural resemblance to E. coli pantothenate kinase. Proteins 54:776-783
9. DeRisi JL, Iyer VR, Brown PO (1997) Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278:680-686
10. Fichtlscherer F, Wellein C, Mittag M, Schweizer E (2000) A novel function of yeast fatty acid synthase. Subunit α is capable of self-pantetheinylation. Eur J Biochem 267:2666-2671
11. Gasch AP, Spellman PT, Kao CM, Carmel-Harel O, Eisen MB, Storz G, Botstein D, Brown PO (2000) Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell 11:4241-4257
12. Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang CY, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418:387-391
13. Gietz RD, Sugino A (1988) New yeast- Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534
14. Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW (2007) Crystal structures of human pantothenate kinases Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. J Biol Chem 282:27984-27993
15. Leonardi R, Zhang YM, Rock CO, Jackowski S (2005) Coenzyme A: Back in action. Prog Lipid Res 44:125-153
16. Mumberg D, Müller R, Funk M (1994) Regulatable promoters of Saccharomyces cerevisiae: Comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res 22:5767-5768
17. Myers AM, Tzagoloff A, Kinney DM, Lusty CJ (1986) Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions. Gene 45:299-310
18. Nosaka K, Onozuka M, Konno H, Kawasaki Y, Nishimura H, Sano M, Akaji K (2005) Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae. Mol Microbiol 58:467-479
19. Rock CO, Calder RB, Karim MA, Jackowski S (2000) Pantothenate kinase regulation of the intracellular concentration of coenzyme A. J Biol Chem 275:1377-1383
20. Roth S, Kumme J, Schüller HJ (2004) Transcriptional activators Cat8 and Sip4 discriminate between sequence variants of the carbon source-responsive promoter element in the yeast Saccharomyces cerevisiae. Curr Genet 45:121-128
21. Ruiz A, Muñoz I, Serrano R, González A, Simón E, Ariño J (2004) Functional characterization of the Saccharomyces cerevisiae VHS3 gene: A regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. J Biol Chem 279:34421-34430
22. Schüller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43:139-160
23. Schüller HJ, Hahn A, Tröster F, Schütz A, Schweizer E (1992) Coordinate genetic control of yeast fatty acid synthetase genes FAS1 and FAS2 by an upstream activation site common to genes involved in the membrane lipid biosynthesis. EMBO J 11:107-114
24. Schwank S, Ebbert R, Rautenstrauss K, Schweizer E, Schüller HJ (1995) Yeast transcriptional activator INO2 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/ choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae. Nucleic Acids Res 23:230-237
25. Schweizer E, Kniep B, Castorph H, Holzner U (1973) Pantetheine-free mutants of the yeast fatty-acid-synthetase complex. Eur J Biochem 39:353-362
26. + -pantothenate symporter. J Biol Chem 274:18747-18752
27. Stolz J, Caspari T, Carr AM, Sauer N (2004) Cell division defects of Schizosaccharomyces pombe liz1 - mutants are caused by defects in pantothenate uptake. Eukaryot Cell 3:406-412
28. Vallari DS, Rock CO (1985) Isolation and characterization of Escherichia coli pantothenate permease (panF) mutants. J Bacteriol 164:136-142
29. Vallari DS, Jackowski S, Rock CO (1987) Regulation of pantothenate kinase by coenzyme A and its thioesters. J Biol Chem 262:2468-2471
30. White WH, Gunyuzlu PL, Toyn JH (2001) Saccharomyces cerevisiae is capable of de novo pantothenic acid biosynthesis involving a novel pathway of β-alanine production from spermine. J Biol Chem 276:10794-10800
31. White WH, Skatrud PL, Xue Z, Toyn JH (2003) Specialization of function among aldehyde dehydrogenases: The ALD2 and ALD3 genes are required for β-alanine biosynthesis in Saccharomyces cerevisiae. Genetics 163:69-77
32. Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, Chu AM, Connelly C, Davis K, Dietrich F, Dow SW, El Bakkoury M, Foury F, Friend SH, Gentalen E, Giaever G, Hegemann JH, Jones T, Laub M, Liao H, Liebundguth N, Lockhart DJ, Lucau-Danila A, Lussier M, M'Rabet N, Menard P, Mittmann M, Pai C, Rebischung C, Revuelta JL, Riles L, Roberts CJ, Ross-MacDonald P, Scherens B, Snyder M, Sookhai-Mahadeo S, Storms RK, Véronneau S, Voet M, Volckaert G, Ward TR, Wysocki R, Yen GS, Yu K, Zimmermann K, Philippsen P, Johnston M, Davis RW (1999) Functional characterization of the S cerevisiae genome by gene deletion and parallel analysis. Science 285:901-906