SCOPUS 정보 검색 플랫폼

Volumn 33, Issue 23, 2012, Pages 1880-1891

Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery

(3) Foster, Theresa J a MacKerell Jr , Alexander D b Guvench, Olgun a

a UNIVERSITY OF NEW ENGLAND (United States)

b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY (United States)

Author keywords

computer aided drug design; immunosuppression; interleukin 2; lead optimization; molecular dynamics simulations; protein protein interactions

Indexed keywords

COMPUTER-AIDED DRUG DESIGN; IMMUNOSUPPRESSION; INTERLEUKIN-2; LEAD OPTIMIZATION; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN-PROTEIN INTERACTIONS;

ACETONITRILE; BINDING SITES; COMPUTATIONAL CHEMISTRY; LIGANDS; MOLECULAR DYNAMICS; MOLECULES; OPTIMIZATION; PROTEINS;

DENATURATION;

INTERLEUKIN 2; LIGAND;

BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; DRUG ANTAGONISM; DRUG DEVELOPMENT; DRUG EFFECT; MOLECULAR DYNAMICS; PROTEIN DENATURATION; REVIEW; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; INTERLEUKIN-2; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN DENATURATION; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863990355 PISSN: 01928651 EISSN: 1096987X Source Type: Journal
DOI: 10.1002/jcc.23026 Document Type: Review

Times cited : (35)

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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.