Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 15, 2012, Pages 4760-4773

  Wang, Fang ^a   Eric Knabe, W ^a   Li, Liwei ^a,b   Jo, Inha ^a   Mani, Timmy ^a   Roehm, Hartmut ^a   Oh, Kyungsoo ^a   Li, Jing ^a   Khanna, May ^a   Meroueh, Samy O ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Lung cancer; Metastasis; Protein protein interaction; Small molecule inhibitors; Structure activity relationship; Structure based drug design; Synthesis; Urokinase receptor; Virtual screening

Indexed keywords

1 HYDROXY 6 METHYLANTHRACENE 9,10 DIONE; 1 HYDROXY 6,7 METHYLANTHRACENE 9,10 DIONE; 1 HYDROXY 7 METHYLANTHRACENE 9,10 DIONE; 2 [(3 BROMO 4 HYDROXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL)AMINO]BENZOIC ACID; 2,4 DIBROMO 1 HYDROXY 6 METHYLANTHRACENE 9,10 DIONE; 2,4 DIBROMO 1 HYDROXY 6,7 DIMETHYLANTHRACENE 9,10 DIONE; 2,4 DIBROMO 1 HYDROXY 7 METHYLANTHRACENE 9,10 DIONE; 2,4 DIBROMO 1 HYDROXYANTHRACENE 9,10 DIONE; 3 [(3 BROMO 4 HYDROXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL)AMINO]BENZOIC ACID; IPR 456; IPR 632; IPR 646; IPR 658; IPR 660; IPR 661; IPR 662; IPR 663; IPR 664; IPR 790; IPR 796; IPR 803; IPR 804; IPR 809; IPR 811; IPR 824; IPR 853; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; UROKINASE RECEPTOR; UROKINASE RECEPTOR INHIBITOR;

ALKYLATION; ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR DYNAMICS; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZOATES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MANNOSE-BINDING LECTINS; MEMBRANE GLYCOPROTEINS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PIPERIDINES; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863987316     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.002     Document Type: Article

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