Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis

Journal of Medicinal Chemistry

Volumn 54, Issue 20, 2011, Pages 7193-7205

  Wang, Fang ^a   Li, Jing ^a   Sinn, Anthony L ^a   Knabe, W Eric ^a   Khanna, May ^a   Jo, Inha ^a   Silver, Jayne M ^a   Oh, Kyungsoo ^a   Li, Liwei ^a   Sandusky, George E ^a   Sledge, George W ^a,b   Nakshatri, Harikrishna ^a,b   Jones, David R ^a   Pollok, Karen E ^a   Meroueh, Samy O ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (BENZO [D] [1,3] DIOXOL 5 YL) N (BENZO [D] [1,3] DIOXOL 5 YLMETHYL) 4 PHENYLBUTAN 1 AMINE; 4[((3 (BENZO [D][1,3] DIOXOL 5 YL) 4 PHENYLBUTYL) AMINO) METHYL] N,N DIMETHYLANILINE; ANTINEOPLASTIC AGENT; GELATINASE B; N (3,5 DIMETHYLPHENYL) 1 (4 ISOPROPYLPHENYL) 5 (PIPERIDIN 4 YL) 1H PYRAZOLE 4 CARBOXAMIDE; UNCLASSIFIED DRUG; UROKINASE RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; BREAST TUMOR; CANCER INVASION; CELL ADHESION; CELL KILLING; CELL MIGRATION; CELL PROLIFERATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; CYTOLOGY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; MAXIMUM PLASMA CONCENTRATION; METASTASIS; MOLECULAR DOCKING; MOUSE; NONHUMAN; TIME TO MAXIMUM PLASMA CONCENTRATION; TUMOR VOLUME; VIRTUAL REALITY;

ANGIOGENESIS INHIBITORS; ANILIDES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DATABASES, FACTUAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MATRIX METALLOPROTEINASE 9; MICE; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; PYRAZOLES; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 80054883036     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200782y     Document Type: Article

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