Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 26878-26888

  Duriseti, Sai ^a   Goetz, David H ^a   Hostetter, Daniel R ^a   LeBeau, Aaron M ^a   Wei, Ying ^b   Craik, Charles S ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN BINDING; CELL INVASION; CELL SIGNALING; COLLAGEN I; COMBINED EFFECT; INTEGRINS; MEDIATED CELLULAR SIGNALING; NON SMALL CELL LUNG CANCER; PHAGE DISPLAY LIBRARIES; TUMOR GROWTH; UROKINASE PLASMINOGEN; UROKINASE PLASMINOGEN ACTIVATORS (UPA); VITRONECTIN;

ADHESION; CELL ADHESION; CELL CULTURE; CHEMICAL DETECTION; COLLAGEN; ENZYME INHIBITION; SIGNALING; TUMORS;

ANTIBODIES;

ALPHA5 INTEGRIN; BETA1 INTEGRIN; COLLAGEN TYPE 1; FIBRONECTIN; ILOMASTAT; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; MATRIGEL; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; UROKINASE RECEPTOR; VITRONECTIN;

ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; BINDING COMPETITION; CANCER CELL CULTURE; CELL ADHESION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; H1299 CELL; HUMAN; HUMAN CELL; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, MONOCLONAL; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PROTEIN BINDING; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; SIGNAL TRANSDUCTION; SPODOPTERA; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 77956251071     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.077677     Document Type: Article

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