HILIC LC-MS for the determination of 2′-C-methyl-cytidine-triphosphate in rat liver

Journal of Separation Science

Volumn 32, Issue 9, 2009, Pages 1275-1283

  Pucci, Vincenzo ^a,b   Giuliano, Claudio ^a   Zhang, Rena ^b   Koeplinger, Kenneth Alan ^b   Leone, Joseph F ^b   Monteagudo, Edith ^a   Bonelli, Fabio ^a  

^a IRBM   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Hydrophilic interaction chromatography; LC MS MS; Liver; Nucleotide

Indexed keywords

96-WELL; AMINOPROPYL; AMMONIUM ACETATE; ANION EXCHANGE; CALIBRATION CURVES; CONCENTRATION RANGES; CYTIDINE; HIGH RELIABILITY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LC-MS/MS; LIVER TISSUE; MOBILE PHASE; MODIFIED NUCLEOSIDES; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; PRETREATMENT PROCEDURE; RAT LIVERS; TRIPHOSPHATE;

AMMONIUM COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; HYDROPHILICITY; LIVER; NUCLEOTIDES; SOLAR RADIATION; SORPTION;

LIQUID CHROMATOGRAPHY;

2' C METHYLCYTIDINE TRIPHOSPHATE; 7 DEAZA 2' C METHYLADENOSINE TRIPHOSPHATE; AMMONIUM ACETATE; NUCLEOSIDE TRIPHOSPHATE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALIBRATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; LIVER; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; REACTION ANALYSIS; RELIABILITY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; SPRAGUE DAWLEY RAT; VALIDATION PROCESS;

ANIMALS; ANTIVIRAL AGENTS; CALIBRATION; CHROMATOGRAPHY, LIQUID; CYTIDINE TRIPHOSPHATE; LIVER; MALE; PRODRUGS; PYRIMIDINE NUCLEOSIDES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; SOLVENTS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 67649979679     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200800722     Document Type: Article

References (23)

1. De Francesco, R., Migliaccio, G., Nature 2005, 436, 953-960.
2. Pierra, C., Amador, A., Benzaria, S., Cretton-Scott, E., D'Amours, M., Mao, J., Mathieu, S., Moussa, A., Bridges, E. G., Standring, D. N., Sommadossi, J. P., Storer, R., Gosselin, G., J. Med. Chem. 2006, 49, 6614-6620.
3. Toniutto, P., Fabris, C., Bitetto, D., Fornasiere, E., Rapetti, R., Pirisi, M., Curr. Opin. Investig. Drugs 2007, 8, 150-158.
4. Darque, A., Valette, G., Rousseau, F., Wang, L. H., Sommadossi, J. P., Zhou, X. J., Antimicrob. Agents Chemother. 1999, 43, 2245-2250.
5. Solas, C., Li, Y. F., Xie, M. Y., Sommadoussi, J. P., Zhou, X. J., Antimicrob. Agents Chemother. 1998, 42, 2989-2995.
6. Robbins, B. L., Tran, T. T., Pinkerton, F. H., Akeb, F., Guedj, R., Grassi, J., Lancaster, D., Fridland, A., Antimicrob. Agents Chemother. 1998, 42, 2656-2660.
7. Moore, K. H. P., Barrett, J. E., Shaw, S., Pakes, G. E., Churchus, R., Kapoor, A., Lloyd, J., Barry, M. G., Back, D., AIDS 1999, 13, 2239-2250.
8. Font, E., Rosario, O., Santana, J., Garcia, H., Sommadossi, J. P., Rodriguez, J. F., Antimicrob. Agents Chemother. 1999, 43, 2964-2968.
9. Moore, J. D., Valette, G., Darque, A., Zhou, X., Sommadossi, J. P., J. Am. Soc. Mass Spectrom. 2000, 11, 1134-1143.
10. Vela, J. E., Olson, L. Y., Huang, A., Fridland, A., Ray, A. S., J. Chromatogr. B 2007, 848, 335-343.
11. Qian, T., Cai, Z., Yang,M. S., Anal. Biochem. 2004, 325, 77-84.
12. Henneré, G., Becher, F., Pruvost, A., Goujard, C., Grassi, J., Benech, H., J. Chromatogr. B 2003, 789, 273-281.
13. St. Claire, R. L., III, Rapid Commun. Mass Spectrom. 2000, 14, 1625-1634.
14. Pruvost, A., Becher, F., Bardouille, P., Guerrero, C., Creminon, C., Delfraissy, J., Goujard, C., Grassi, J., Benech, H., Rapid Commun. Mass Spectrom. 2001, 15, 1401-1408.
15. Fung, E. N., Cai, Z., Burnette, T. C., Sinhababu, A. K., J. Chromatogr. B 2001, 754, 285-295.
16. Cai, Z., Anal. Sci. 2001, 17, 199-207.
17. Shi, G., Wu, J. T., Li, Y., Geleziunas, R., Gallagher, K., Emm, T., Olah, T., Unger, S., Rapid Commun. Mass Spectrom. 2002, 16, 1092-1099.
18. Faletto, M. B., Miller, W. H., Garvey, E. P., St. Clair, M. H., Daluge, S. M., Good, S. S., Antimicrob. Agents Chemother. 1997, 41, 1099-1107.
19. Zell, M., Husser, C., Hopfgartner, G., J. Mass Spectrom. 1997, 32, 23-32.
20. Bajad, S. U., Lu, W., Kimball, E. H., Yuan, J., Peterson, C., Rabinowitz, J. D., J. Chromatogr. A 2006, 1125, 76-88.
21. Xing, J., Apedo, A., Tymiak, A., Zhao, N., Rapid Commun. Mass Spectrom. 2004, 18, 1599-1606.
22. Bansal, S., DeStefano, A., AAPS J. 2007, 9, 109-114.
23. Gonzalez, B., Francois, J., Renaud, M., Yeast 1997, 13, 1347-1355.