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Volumn 397, Issue 4, 2012, Pages 569-578

Targeting the vasculature of visceral tumors: Novel insights and treatment perspectives

Author keywords

Angiogenesis; Anti angiogenic therapy; Cancer stem cell; Colorectal cancer; Hepatocellular carcinoma; Pancreatic cancer; Renal cell cancer; Tumor; Vascular targeting

Indexed keywords

AFLIBERCEPT; ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; AXITINIB; BAVITUXIMAB; BEVACIZUMAB; BREAST CANCER RESISTANCE PROTEIN; CATIONIC LIPOSOME; CD133 ANTIGEN; ENDOTAG 1; ERLOTINIB; EVEROLIMUS; GEMCITABINE; HYPOXIA INDUCIBLE FACTOR; LIPOSOME; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PACLITAXEL; PAZOPANIB; PROTEIN TYROSINE KINASE INHIBITOR; RAMUCIRUMAB; SORAFENIB; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

EID: 84863983366     PISSN: 14352443     EISSN: 14352451     Source Type: Journal    
DOI: 10.1007/s00423-012-0946-4     Document Type: Review
Times cited : (3)

References (82)
  • 1
    • 0021978223 scopus 로고
    • Tumor angiogenesis
    • Folkman J (1985) Tumor angiogenesis. Adv Cancer Res 43:175-203
    • (1985) Adv Cancer Res , vol.43 , pp. 175-203
    • Folkman, J.1
  • 2
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissue in vivo
    • Algire GH, Chalkley HW (1945) Vascular reactions of normal and malignant tissue in vivo. J Natl Cancer Inst 6:73-85
    • (1945) J Natl Cancer Inst , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2
  • 3
    • 0026846928 scopus 로고
    • The role of angiogenesis in tumor growth
    • Folkman J (1992) The role of angiogenesis in tumor growth. Semin Cancer Biol 3:65-71
    • (1992) Semin Cancer Biol , vol.3 , pp. 65-71
    • Folkman, J.1
  • 4
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J (2002) Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29:15-18
    • (2002) Semin Oncol , vol.29 , pp. 15-18
    • Folkman, J.1
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285:1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 8
    • 1542319129 scopus 로고    scopus 로고
    • Cancer without disease
    • DOI 10.1038/427787a
    • Folkman J, Kalluri R (2004) Cancer without disease. Nature 427:787 (Pubitemid 38297724)
    • (2004) Nature , vol.427 , Issue.6977 , pp. 787
    • Folkman, J.1    Kalluri, R.2
  • 10
    • 34249979533 scopus 로고    scopus 로고
    • Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
    • DOI 10.1182/blood-2006-10-053504
    • Venneri MA, De PM, Ponzoni M, Pucci F, Scielzo C, Zonari E, Mazzieri R, Doglioni C, Naldini L (2007) Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood 109:5276-5285 (Pubitemid 46890548)
    • (2007) Blood , vol.109 , Issue.12 , pp. 5276-5285
    • Venneri, M.A.1    De Palma, M.2    Ponzoni, M.3    Pucci, F.4    Scielzo, C.5    Zonari, E.6    Mazzieri, R.7    Doglioni, C.8    Naldini, L.9
  • 11
    • 34548798765 scopus 로고    scopus 로고
    • Tie2-expressing monocytes and tumor angiogenesis: Regulation by hypoxia and angiopoietin-2
    • DOI 10.1158/0008-5472.CAN-07-1684
    • Lewis CE, De PM, Naldini L (2007) Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. Cancer Res 67:8429-8432 (Pubitemid 47437413)
    • (2007) Cancer Research , vol.67 , Issue.18 , pp. 8429-8432
    • Lewis, C.E.1    De Palma, M.2    Naldini, L.3
  • 13
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306-1309 (Pubitemid 20066716)
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 16
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23:1011-1027 (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 18
    • 34447130180 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (Avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer
    • DOI 10.1634/theoncologist.12-6-713
    • Cohen MH, Gootenberg J, Keegan P, Pazdur R (2007) FDA drug approval summary: bevacizumab (Avastin) plus Carboplatin and Paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer. Oncologist 12:713-718 (Pubitemid 47036205)
    • (2007) Oncologist , vol.12 , Issue.6 , pp. 713-718
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 20
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M, Ferrara N (1997) Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 57:4593-4599 (Pubitemid 27441066)
    • (1997) Cancer Research , vol.57 , Issue.20 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 21
    • 77950494294 scopus 로고    scopus 로고
    • Effect of bevacizumab in older patients with metastatic colorectal cancer: Pooled analysis of four randomized studies
    • Cassidy J, Saltz LB, Giantonio BJ, Kabbinavar FF, Hurwitz HI, Rohr UP (2010) Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies. J Cancer Res Clin Oncol 136:737-743
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 737-743
    • Cassidy, J.1    Saltz, L.B.2    Giantonio, B.J.3    Kabbinavar, F.F.4    Hurwitz, H.I.5    Rohr, U.P.6
  • 24
    • 77954682879 scopus 로고    scopus 로고
    • Ramucirumab (IMC-1121B): A novel attack on angiogenesis
    • Spratlin JL, Mulder KE, Mackey JR (2010) Ramucirumab (IMC-1121B): a novel attack on angiogenesis. Future Oncol 6:1085-1094
    • (2010) Future Oncol , vol.6 , pp. 1085-1094
    • Spratlin, J.L.1    Mulder, K.E.2    MacKey, J.R.3
  • 25
    • 0037137903 scopus 로고    scopus 로고
    • Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy
    • DOI 10.1002/ijc.1634
    • Lu D, Jimenez X, Zhang H, Bohlen P, Witte L, Zhu Z (2002) Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy. Int J Cancer 97:393-399 (Pubitemid 34049034)
    • (2002) International Journal of Cancer , vol.97 , Issue.3 , pp. 393-399
    • Lu, D.1    Jimenez, X.2    Zhang, H.3    Bohlen, P.4    Witte, L.5    Zhu, Z.6
  • 29
    • 79955845255 scopus 로고    scopus 로고
    • Targeted therapies for the treatment of metastatic renal cell carcinoma: Clinical evidence
    • Hutson TE (2011) Targeted therapies for the treatment of metastatic renal cell carcinoma: clinical evidence. Oncologist 16(Suppl 2):14-22
    • (2011) Oncologist , vol.16 , Issue.SUPPL. 2 , pp. 14-22
    • Hutson, T.E.1
  • 30
  • 31
    • 77953725220 scopus 로고    scopus 로고
    • Targeted treatments in colorectal cancer: State of the art and future perspectives
    • Arnold D, Seufferlein T (2010) Targeted treatments in colorectal cancer: state of the art and future perspectives. Gut 59:838-858
    • (2010) Gut , vol.59 , pp. 838-858
    • Arnold, D.1    Seufferlein, T.2
  • 32
    • 79952697854 scopus 로고    scopus 로고
    • Targeting mTOR in cancer: Renal cell is just a beginning
    • Azim H, Azim HA Jr, Escudier B (2010) Targeting mTOR in cancer: renal cell is just a beginning. Target Oncol 5:269-280
    • (2010) Target Oncol , vol.5 , pp. 269-280
    • Azim, H.1    Azim Jr., H.A.2    Escudier, B.3
  • 33
    • 20344367537 scopus 로고    scopus 로고
    • Tumour vascular targeting
    • DOI 10.1038/nrc1627
    • Neri D, Bicknell R (2005) Tumour vascular targeting. Nat Rev Cancer 5:436-446 (Pubitemid 40791486)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.6 , pp. 436-446
    • Neri, D.1    Bicknell, R.2
  • 35
    • 0142155561 scopus 로고    scopus 로고
    • Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response
    • DOI 10.1016/S0360-3016(03)00769-7
    • Horsman MR, Murata R (2003) Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response. Int J Radiat Oncol Biol Phys 57:1047-1055 (Pubitemid 37324123)
    • (2003) International Journal of Radiation Oncology Biology Physics , vol.57 , Issue.4 , pp. 1047-1055
    • Horsman, M.R.1    Murata, R.2
  • 36
    • 79551570717 scopus 로고    scopus 로고
    • Classification and toxicities of vascular disrupting agents
    • Hasani A, Leighl N (2011) Classification and toxicities of vascular disrupting agents. Clin Lung Cancer 12:18-25
    • (2011) Clin Lung Cancer , vol.12 , pp. 18-25
    • Hasani, A.1    Leighl, N.2
  • 44
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
    • DOI 10.1126/science.1125950
    • Kerbel RS (2006) Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science 312:1171-1175 (Pubitemid 43801134)
    • (2006) Science , vol.312 , Issue.5777 , pp. 1171-1175
    • Kerbel, R.S.1
  • 46
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • DOI 10.1038/nm0901-987
    • Jain RK (2001) Normalizing tumor vasculature with antiangiogenic therapy: a new paradigm for combination therapy. Nat Med 7:987-989 (Pubitemid 32937367)
    • (2001) Nature Medicine , vol.7 , Issue.9 , pp. 987-989
    • Jain, R.K.1
  • 47
    • 79551642429 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Implications for combination with conventional therapies
    • Moschetta M, Cesca M, Pretto F, Giavazzi R (2010) Angiogenesis inhibitors: implications for combination with conventional therapies. Curr Pharm Des 16:3921-3931
    • (2010) Curr Pharm des , vol.16 , pp. 3921-3931
    • Moschetta, M.1    Cesca, M.2    Pretto, F.3    Giavazzi, R.4
  • 48
    • 33847638137 scopus 로고    scopus 로고
    • Estimates of the cancer incidence and mortality in Europe in 2006
    • DOI 10.1093/annonc/mdl498
    • Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P (2007) Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 18:581-592 (Pubitemid 46359643)
    • (2007) Annals of Oncology , vol.18 , Issue.3 , pp. 581-592
    • Ferlay, J.1    Autier, P.2    Boniol, M.3    Heanue, M.4    Colombet, M.5    Boyle, P.6
  • 50
    • 33751115483 scopus 로고    scopus 로고
    • Correlation of four vascular specific growth factors with carcinogenesis and portal vein tumor thrombus formation in human hepatocellular carcinoma
    • Li Q, Xu B, Fu L, Hao XS (2006) Correlation of four vascular specific growth factors with carcinogenesis and portal vein tumor thrombus formation in human hepatocellular carcinoma. J Exp Clin Cancer Res 25:403-409 (Pubitemid 44763732)
    • (2006) Journal of Experimental and Clinical Cancer Research , vol.25 , Issue.3 , pp. 403-409
    • Li, Q.1    Xu, B.2    Fu, L.3    Hao, X.S.4
  • 54
    • 78650373860 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors: Master regulators of metastasis
    • Lu X, Kang Y (2010) Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 16:5928-5935
    • (2010) Clin Cancer Res , vol.16 , pp. 5928-5935
    • Lu, X.1    Kang, Y.2
  • 55
    • 66749114931 scopus 로고    scopus 로고
    • MTOR in renal cell cancer: Modulator of tumor biology and therapeutic target
    • Wysocki PJ (2009) mTOR in renal cell cancer: modulator of tumor biology and therapeutic target. Expert Rev Mol Diagn 9:231-241
    • (2009) Expert Rev Mol Diagn , vol.9 , pp. 231-241
    • Wysocki, P.J.1
  • 57
    • 76049128595 scopus 로고    scopus 로고
    • Estimates of cancer incidence and mortality in Europe in 2008
    • Ferlay J, Parkin DM, Steliarova-Foucher E (2010) Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 46:765-781
    • (2010) Eur J Cancer , vol.46 , pp. 765-781
    • Ferlay, J.1    Parkin, D.M.2    Steliarova-Foucher, E.3
  • 58
    • 72549116624 scopus 로고    scopus 로고
    • Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: Vasculature-independent radiosensitizing effect of bevacizumab
    • Koukourakis MI,Giatromanolaki A, Sheldon H, Buffa FM, Kouklakis G, Ragoussis I, Sivridis E, Harris AL (2009) Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab. Clin Cancer Res 15:7069-7076
    • (2009) Clin Cancer Res , vol.15 , pp. 7069-7076
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sheldon, H.3    Buffa, F.M.4    Kouklakis, G.5    Ragoussis, I.6    Sivridis, E.7    Harris, A.L.8
  • 59
    • 81255142967 scopus 로고    scopus 로고
    • Targeted therapy with bevacizumab (Avastin) for metastatic colorectal cancer
    • Koukourakis GV, Sotiropoulou-Lontou A (2011) Targeted therapy with bevacizumab (Avastin) for metastatic colorectal cancer. Clin Transl Oncol 13:710-714
    • (2011) Clin Transl Oncol , vol.13 , pp. 710-714
    • Koukourakis, G.V.1    Sotiropoulou-Lontou, A.2
  • 62
    • 84861190138 scopus 로고    scopus 로고
    • A preclinical and clinical review of aflibercept for the management of cancer
    • press
    • Gaya A, Tse V (2012) A preclinical and clinical review of aflibercept for the management of cancer. Cancer Treat Rev (in press)
    • (2012) Cancer Treat Rev
    • Gaya, A.1    Tse, V.2
  • 64
    • 84863011440 scopus 로고    scopus 로고
    • Aflibercept in the treatment of metastatic colorectal cancer
    • Wang TF, Lockhart AC (2012) Aflibercept in the treatment of metastatic colorectal cancer. Clin Med Insights Oncol 6:19-30
    • (2012) Clin Med Insights Oncol , vol.6 , pp. 19-30
    • Wang, T.F.1    Lockhart, A.C.2
  • 65
    • 77958198446 scopus 로고    scopus 로고
    • Aflibercept (VEGF Trap): One more double-edged sword of anti-VEGF therapy for cancer?
    • Jin K, Shen Y, He K, Xu Z, Li G, Teng L (2010) Aflibercept (VEGF Trap): one more double-edged sword of anti-VEGF therapy for cancer? Clin Transl Oncol 12:526-532
    • (2010) Clin Transl Oncol , vol.12 , pp. 526-532
    • Jin, K.1    Shen, Y.2    He, K.3    Xu, Z.4    Li, G.5    Teng, L.6
  • 67
    • 53549092538 scopus 로고    scopus 로고
    • Targeting angiogenesis in pancreatic cancer: Rationale and pitfalls
    • Whipple C, Korc M (2008) Targeting angiogenesis in pancreatic cancer: rationale and pitfalls. Langenbecks Arch Surg 393:901-910
    • (2008) Langenbecks Arch Surg , vol.393 , pp. 901-910
    • Whipple, C.1    Korc, M.2
  • 68
    • 70649098156 scopus 로고    scopus 로고
    • Chemoradiotherapy with concurrent gemcitabine and cisplatin with or without sequential chemotherapy with gemcitabine/ cisplatin vs chemoradiotherapy with concurrent 5-fluorouracil in patients with locally advanced pancreatic cancer-A multi-centre randomised phase II stud
    • Wilkowski R, Boeck S, Ostermaier S, Sauer R, Herbst M, Fietkau R, Flentje M, Miethe S, Boettcher HD, Scholten T, Bruns CJ, Rau HG et al (2009) Chemoradiotherapy with concurrent gemcitabine and cisplatin with or without sequential chemotherapy with gemcitabine/ cisplatin vs chemoradiotherapy with concurrent 5-fluorouracil in patients with locally advanced pancreatic cancer-a multi-centre randomised phase II stud. Br J Cancer 101:1853-1859
    • (2009) Br J Cancer , vol.101 , pp. 1853-1859
    • Wilkowski, R.1    Boeck, S.2    Ostermaier, S.3    Sauer, R.4    Herbst, M.5    Fietkau, R.6    Flentje, M.7    Miethe, S.8    Boettcher, H.D.9    Scholten, T.10    Bruns, C.J.11    Rau, H.G.12
  • 69
    • 84855244327 scopus 로고    scopus 로고
    • Chemotherapy of metastatic pancreatic adenocarcinoma: Challenges and encouraging results
    • Conroy T, Mitry E (2011) Chemotherapy of metastatic pancreatic adenocarcinoma: challenges and encouraging results. Bull Cancer 98:1439-1446
    • (2011) Bull Cancer , vol.98 , pp. 1439-1446
    • Conroy, T.1    Mitry, E.2
  • 70
    • 79958119999 scopus 로고    scopus 로고
    • Anti-angiogenic agents in pancreatic cancer: A review
    • Assifi MM, Hines OJ (2011) Anti-angiogenic agents in pancreatic cancer: a review. Anticancer Agents Med Chem 11:464-469
    • (2011) Anticancer Agents Med Chem , vol.11 , pp. 464-469
    • Assifi, M.M.1    Hines, O.J.2
  • 73
    • 84866733344 scopus 로고    scopus 로고
    • Phase i study of axitinib (AG-013736) in combination with gemcitabine in patients with advanced pancreatic cancer
    • Spano JP, Moore MJ, Pithavala YK, Ricart AD, Kim S, Rixe O (2011) Phase I study of axitinib (AG-013736) in combination with gemcitabine in patients with advanced pancreatic cancer. Investig New Drugs
    • (2011) Investig New Drugs
    • Spano, J.P.1    Moore, M.J.2    Pithavala, Y.K.3    Ricart, A.D.4    Kim, S.5    Rixe, O.6
  • 77
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • DOI 10.1038/nm0797-730
    • Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3:730-737 (Pubitemid 27298715)
    • (1997) Nature Medicine , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 79
    • 80054974211 scopus 로고    scopus 로고
    • Stem cells, quiescence and rectal carcinoma: An unexplored relationship and potential therapeutic target
    • Buczacki S, Davies RJ, Winton DJ (2011) Stem cells, quiescence and rectal carcinoma: an unexplored relationship and potential therapeutic target. Br J Cancer 105:1253-1259
    • (2011) Br J Cancer , vol.105 , pp. 1253-1259
    • Buczacki, S.1    Davies, R.J.2    Winton, D.J.3
  • 81
    • 77951224759 scopus 로고    scopus 로고
    • ABCG2: A potential marker of stem cells and novel target in stem cell and cancer therapy
    • Ding XW, Wu JH, Jiang CP (2010) ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy. Life Sci 86:631-637
    • (2010) Life Sci , vol.86 , pp. 631-637
    • Ding, X.W.1    Wu, J.H.2    Jiang, C.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.