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Volumn 13, Issue 10, 2011, Pages 710-714

Targeted therapy with bevacizumab (Avastin) for metastatic colorectal cancer

Author keywords

Avastin; Bevacizumab; Metastatic colorectal cancer

Indexed keywords

BEVACIZUMAB; CAPECITABINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PLACEBO; VASCULOTROPIN A; VASCULOTROPIN E; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 81255142967     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-011-0720-z     Document Type: Review
Times cited : (38)

References (31)
  • 1
    • 51549117737 scopus 로고    scopus 로고
    • National Cancer Institute. SEER, Bethesda, MD
    • Ries LAG, Melbert D (2008) SEER Cancer Statistics Review, 1975-2005, National Cancer Institute. SEER, Bethesda, MD. http://seer.cancer.gov/csr/1975- 2005/, based on November 2007 SEER data submission, posted to the SEER website
    • (2008) SEER Cancer Statistics Review, 1975-2005
    • Ries, L.A.G.1    Melbert, D.2
  • 2
    • 84855842434 scopus 로고    scopus 로고
    • Cancer.net. Available at
    • Cancer.net. Colorectal cancer: overview. Available at http://www.cancer.net/patient/Cancer+Types/Colorectal+Cancer
    • Colorectal cancer: Overview
  • 3
    • 0028114985 scopus 로고
    • The implications of angiogenesis for the biology and therapy of cancer metastasis
    • DOI 10.1016/0092-8674(94)90187-2
    • I.J. Fidler L.M. Ellis 1994 The implications of angiogenesis for the biology and therapy of cancer metastasis Cell 79 185 188 7525076 10.1016/0092-8674(94)90187-2 1:CAS:528:DyaK2cXmslOltLY%3D (Pubitemid 24324908)
    • (1994) Cell , vol.79 , Issue.2 , pp. 185-188
    • Fidler, I.J.1    Ellis, L.M.2
  • 4
    • 0015221083 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • 4938153 10.1056/NEJM197108122850711 1:STN:280:DyaE38%2FgvVCqsQ%3D%3D
    • J. Folkman 1971 Tumor angiogenesis: therapeutic implications N Engl J Med 285 1182 1186 4938153 10.1056/NEJM197108122850711 1:STN:280: DyaE38%2FgvVCqsQ%3D%3D
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 5
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • N. Ferrara H.P. Gerber J. LeCouter 2003 The biology of VEGF and its receptors Nat Med 9 669 676 12778165 10.1038/nm0603-669 1:CAS:528: DC%2BD3sXktFOnur4%3D (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    LeCouter, J.3
  • 6
    • 33344463349 scopus 로고    scopus 로고
    • Discovery of vascular permeability factor (VPF)
    • DOI 10.1016/j.yexcr.2005.11.026, PII S0014482705005616
    • H.F. Dvorak 2006 Discovery of vascular permeability factor (VPF) Exp Cell Res 312 522 526 16430882 10.1016/j.yexcr.2005.11.026 1:CAS:528: DC%2BD28XhvVWltb8%3D (Pubitemid 43290329)
    • (2006) Experimental Cell Research , vol.312 , Issue.5 , pp. 522-526
    • Dvorak, H.F.1
  • 8
    • 0030721770 scopus 로고    scopus 로고
    • Characterization of the extracellular domain in vascular endothelial growth factor receptor-1 (Flt-1 tyrosine kinase)31
    • K. Tanaka S. Yamaguchi A. Sawano M. Shibuya 1997 Characterization of the extracellular domain in vascular endothelial growth factor receptor-1 (Flt-1 tyrosine kinase) Jpn J Cancer Res 88 867 876 9369935 10.1111/j.1349-7006.1997. tb00463.x 1:CAS:528:DyaK2sXms12hur4%3D (Pubitemid 27475089)
    • (1997) Japanese Journal of Cancer Research , vol.88 , Issue.9 , pp. 867-876
    • Tanaka, K.1    Yamaguchi, S.2    Sawano, A.3    Shibuya, M.4
  • 9
    • 1542571789 scopus 로고    scopus 로고
    • Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration
    • 14514674 10.1074/jbc.M310047200 1:CAS:528:DC%2BD3sXptlGkurw%3D
    • L. Wang H. Zeng P. Wang, et al. 2003 Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration J Biol Chem 278 48848 48860 14514674 10.1074/jbc.M310047200 1:CAS:528:DC%2BD3sXptlGkurw%3D
    • (2003) J Biol Chem , vol.278 , pp. 48848-48860
    • Wang, L.1    Zeng, H.2    Wang, P.3
  • 10
    • 43049147668 scopus 로고    scopus 로고
    • Prognostic Significance of VEGF Expression Evaluated by Quantitative Immunohistochemical Analysis in Colorectal Cancer
    • DOI 10.1016/j.jss.2007.05.041, PII S0022480407004027
    • K. Zafirellis G. Agrogiannis A. Zachaki, et al. 2008 Prognostic significance of VEGF expression evaluated by quantitative immunohistochemical analysis in colorectal cancer J Surg Res 147 99 107 17655863 10.1016/j.jss.2007.05.041 1:CAS:528:DC%2BD1cXlslaiu7Y%3D (Pubitemid 351626074)
    • (2008) Journal of Surgical Research , vol.147 , Issue.1 , pp. 99-107
    • Zafirellis, K.1    Agrogiannis, G.2    Zachaki, A.3    Gravani, K.4    Karameris, A.5    Kombouras, C.6
  • 11
    • 0030037264 scopus 로고    scopus 로고
    • Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma
    • DOI 10.1002/(SICI)1097-0142(19960715)78:2<226::AID-CNCR6>3.0.CO;2-J
    • Y. Takebayashi S. Aklyama K. Yamada, et al. 1996 Angiogenesis as an unfavourable prognostic factor in human colorectal carcinoma Cancer 78 226 231 8673996 10.1002/(SICI)1097-0142(19960715)78:2<226::AID-CNCR6>3.0.CO;2-J 1:STN:280:DyaK283osVartQ%3D%3D (Pubitemid 26234563)
    • (1996) Cancer , vol.78 , Issue.2 , pp. 226-231
    • Takebayashi, Y.1    Akiyama, S.-I.2    Yamada, K.3    Akiba, S.4    Aikou, T.5
  • 12
    • 0030059075 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth
    • O. Melnyk M.A. Shuman K.J. Kim 1996 Vascular endothelial growth factor promotes tumour dissemination by a mechanism distinct from its effect on primary tumour growth Cancer Res 56 921 924 8631034 1:CAS:528:DyaK28XhtVCltrc%3D (Pubitemid 26055486)
    • (1996) Cancer Research , vol.56 , Issue.4 , pp. 921-924
    • Melnyk, O.1    Shuman, M.A.2    Kim, K.J.3
  • 13
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • DOI 10.1038/362841a0
    • K.J. Kim B. Li J. Winer, et al. 1993 Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo Nature 362 841 844 7683111 10.1038/362841a0 1:CAS:528:DyaK3sXktVKju7s%3D (Pubitemid 23132159)
    • (1993) Nature , vol.362 , Issue.6423 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 14
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • 7535799 10.1172/JCI117857 1:CAS:528:DyaK2MXkslyktb4%3D
    • R.S. Warren H. Yuan M.R. Matli, et al. 1995 Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis J Clin Invest 95 1789 1797 7535799 10.1172/JCI117857 1:CAS:528:DyaK2MXkslyktb4%3D
    • (1995) J Clin Invest , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3
  • 15
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumour regression without overt toxicity
    • 10772661 10.1172/JCI8829 1:CAS:528:DC%2BD3cXisFOlurc%3D
    • G. Klement S. Baruchel J. Rak, et al. 2000 Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumour regression without overt toxicity J Clin Invest 105 R15 24 10772661 10.1172/JCI8829 1:CAS:528:DC%2BD3cXisFOlurc%3D
    • (2000) J Clin Invest , vol.105 , pp. 15-24
    • Klement, G.1    Baruchel, S.2    Rak, J.3
  • 16
    • 0033822622 scopus 로고    scopus 로고
    • Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
    • 11005565 10.1038/sj.neo.7900102 1:CAS:528:DC%2BD3cXntVCjtb8%3D
    • J.L. Rubenstein J. Kim T. Ozawa, et al. 2000 Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption Neoplasia 2 306 314 11005565 10.1038/sj.neo.7900102 1:CAS:528: DC%2BD3cXntVCjtb8%3D
    • (2000) Neoplasia , vol.2 , pp. 306-314
    • Rubenstein, J.L.1    Kim, J.2    Ozawa, T.3
  • 18
    • 0035253586 scopus 로고    scopus 로고
    • Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: Pharmacologic and long-term safety data
    • K. Margolin M.S. Gordon E. Holmgren, et al. 2001 Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data J Clin Oncol 19 851 856 11157039 1:CAS:528:DC%2BD3MXhtlGrt7Y%3D (Pubitemid 32119101)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.3 , pp. 851-856
    • Margolin, K.1    Gordon, M.S.2    Holmgren, E.3    Gaudreault, J.4    Novotny, W.5    Fyfe, G.6    Adelman, D.7    Stalter, S.8    Breed, J.9
  • 22
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • DOI 10.1038/nm0901-987
    • R.K. Jain 2001 Normalizing tumour vasculature with anti-angiogenic therapy: a new paradigm for combination therapy Nat Med 7 987 989 11533692 10.1038/nm0901-987 1:CAS:528:DC%2BD3MXmvFOmsrc%3D (Pubitemid 32937367)
    • (2001) Nature Medicine , vol.7 , Issue.9 , pp. 987-989
    • Jain, R.K.1
  • 24
    • 20644432867 scopus 로고    scopus 로고
    • Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer
    • 15908660 10.1200/JCO.2005.10.017 1:CAS:528:DC%2BD2MXlsVyhsrs%3D
    • H.I. Hurwitz L. Fehrenbacher J.D. Hainsworth, et al. 2005 Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer J Clin Oncol 23 3502 3508 15908660 10.1200/JCO.2005.10.017 1:CAS:528:DC%2BD2MXlsVyhsrs%3D
    • (2005) J Clin Oncol , vol.23 , pp. 3502-3508
    • Hurwitz, H.I.1    Fehrenbacher, L.2    Hainsworth, J.D.3
  • 25
    • 84857115496 scopus 로고    scopus 로고
    • Avastin prescribing information. Available at Accessed20July2006
    • Avastin prescribing information. Available at http://www.gene.com/gene/ products/information/pdf/avastin-prescribing.pdf. Accessed 20 July 2006
  • 27
    • 39149108869 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Updated results from the BICC-C study
    • DOI 10.1200/JCO.2007.15.5390
    • C.S. Fuchs J. Marshall J. Barrueco 2008 Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: updated results from the BICC-C study J Clin Oncol 26 689 690 18235136 10.1200/JCO.2007.15.5390 (Pubitemid 351264373)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.4 , pp. 689-690
    • Fuchs, C.S.1    Marshall, J.2    Barrueco, J.3
  • 28
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • 18421054 10.1200/JCO.2007.14.9930 1:CAS:528:DC%2BD1cXlvFaqs7g%3D
    • L.B. Saltz S. Clarke E. Díaz-Rubio, et al. 2008 Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study J Clin Oncol 26 2013 2019 18421054 10.1200/JCO.2007.14.9930 1:CAS:528:DC%2BD1cXlvFaqs7g%3D
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Díaz-Rubio, E.3
  • 30
    • 66349096540 scopus 로고    scopus 로고
    • CAPIRI (capecitabine, irinotecan)+bevacizumab vs FOLFIRI (folinic acid, 5 fluorouracil, irinotecan)+bevacizumab for the treatment of patients with metastatic colorectal cancer (mCRC): Interim analysis for safety of a randomized phase III trial
    • N. Ziras A. Polyzos S. Kakolyris 2008 CAPIRI (capecitabine, irinotecan)+bevacizumab vs FOLFIRI (folinic acid, 5 fluorouracil, irinotecan)+bevacizumab for the treatment of patients with metastatic colorectal cancer (mCRC): interim analysis for safety of a randomized phase III trial J Clin Oncol 26 [Suppl20] 15008
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. 20 , pp. 15008
    • Ziras, N.1    Polyzos, A.2    Kakolyris, S.3
  • 31
    • 34848827362 scopus 로고    scopus 로고
    • Association between exposure to bevacizumab (BV) beyond first progression (BBP) and overall survival (OS) in patients (pts) with metastatic colorectal cancer (mCRC): Results from a large observational study (BRiTE)
    • A. Grothey M. Sugrue E. Hedrick 2007 Association between exposure to bevacizumab (BV) beyond first progression (BBP) and overall survival (OS) in patients (pts) with metastatic colorectal cancer (mCRC): results from a large observational study (BRiTE) J Clin Oncol 25 [Suppl18] 4036
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18 , pp. 4036
    • Grothey, A.1    Sugrue, M.2    Hedrick, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.