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Volumn 6, Issue , 2012, Pages 19-30

Aflibercept in the treatment of metastatic colorectal cancer

Author keywords

Aflibercept; Angiogenesis; Colorectal cancer; Targeted therapy; VEGF; VEGFR

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; CETUXIMAB; DOCETAXEL; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; PAZOPANIB; PLACEBO; PREDNISONE; RAMUCIRUMAB; SORAFENIB; SUNITINIB; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VATALANIB;

EID: 84863011440     PISSN: 11795549     EISSN: 11795549     Source Type: Journal    
DOI: 10.4137/CMO.S7432     Document Type: Review
Times cited : (46)

References (60)
  • 3
    • 84898699852 scopus 로고    scopus 로고
    • American Cancer Society. Cancer Facts and Figures 2011. Available from, Accessed November 18
    • American Cancer Society. Cancer Facts and Figures 2011. Available from: http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-029771.pdf. Accessed November 18, 2011.
    • (2011)
  • 4
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971;285:1182-6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 6
    • 84555197776 scopus 로고    scopus 로고
    • An update on the current and emerging targeted agents in metastatic colorectal cancer
    • July 11, Epub ahead of print
    • Chu E. An update on the current and emerging targeted agents in metastatic colorectal cancer. Clin Colorectal Cancer. July 11, 2011. [Epub ahead of print.]
    • (2011) Clin Colorectal Cancer
    • Chu, E.1
  • 7
    • 0242624629 scopus 로고    scopus 로고
    • Molecular basis of angiogenesis and cancer
    • Tonini T, Rossi F, Claudio PP. Molecular basis of angiogenesis and cancer. Oncogene. 2003;22:6549-56.
    • (2003) Oncogene , vol.22 , pp. 6549-6556
    • Tonini, T.1    Rossi, F.2    Claudio, P.P.3
  • 8
    • 29944445729 scopus 로고    scopus 로고
    • Anti-angiogenic treatment of gastrointestinal malignancies
    • Salmon JS, Lockhart AC, Berlin J. Anti-angiogenic treatment of gastrointestinal malignancies. Cancer Invest. 2005;23:712-26.
    • (2005) Cancer Invest , vol.23 , pp. 712-726
    • Salmon, J.S.1    Lockhart, A.C.2    Berlin, J.3
  • 10
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med. 2008;358:2039-49.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 11
    • 0034693879 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis
    • Karkkainen MJ, Petrova TV. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis. Oncogene. 2000;19: 5598-605.
    • (2000) Oncogene , vol.19 , pp. 5598-5605
    • Karkkainen, M.J.1    Petrova, T.V.2
  • 12
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 995;376:66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 13
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci U S A. 1998;95:9349-54.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 14
    • 0035920244 scopus 로고    scopus 로고
    • Vascular permeability factor (VPF)/ vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways
    • Zeng H, Dvorak HF, Mukhopadhyay D. Vascular permeability factor (VPF)/ vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways. J Biol Chem. 2001;276:26969-79.
    • (2001) J Biol Chem , vol.276 , pp. 26969-26979
    • Zeng, H.1    Dvorak, H.F.2    Mukhopadhyay, D.3
  • 15
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005;23:1011-27.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 16
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    • Shalaby F, Rossant J, Yamaguchi TP, et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995;376:62-6.
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.P.3
  • 17
    • 0033862310 scopus 로고    scopus 로고
    • Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase
    • Irrthum A, Karkkainen MJ, Devriendt K, Alitalo K, Vikkula M. Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase. Am J Hum Genet. 2000;67:295-301.
    • (2000) Am J Hum Genet , vol.67 , pp. 295-301
    • Irrthum, A.1    Karkkainen, M.J.2    Devriendt, K.3    Alitalo, K.4    Vikkula, M.5
  • 18
    • 0035150839 scopus 로고    scopus 로고
    • Localization of vascular endothelial growth factor-D in malignant melanoma suggests a role in tumour angiogenesis
    • Achen MG, Williams RA, Minekus MP, et al. Localization of vascular endothelial growth factor-D in malignant melanoma suggests a role in tumour angiogenesis. J Pathol. 2001;193:147-54.
    • (2001) J Pathol , vol.193 , pp. 147-154
    • Achen, M.G.1    Williams, R.A.2    Minekus, M.P.3
  • 19
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 1995;55:3964-8.
    • (1995) Cancer Res , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3    Cleary, K.R.4    Ellis, L.M.5
  • 20
    • 1842415455 scopus 로고    scopus 로고
    • Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer
    • Takahashi Y, Tucker SL, Kitadai Y, et al. Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer. Arch Surg. 1997;132:541-6.
    • (1997) Arch Surg , vol.132 , pp. 541-546
    • Takahashi, Y.1    Tucker, S.L.2    Kitadai, Y.3
  • 21
    • 0033941120 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer
    • Cascinu S, Staccioli MP, Gasparini G, et al. Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer. Clin Cancer Res. 2000;6:2803-7.
    • (2000) Clin Cancer Res , vol.6 , pp. 2803-2807
    • Cascinu, S.1    Staccioli, M.P.2    Gasparini, G.3
  • 22
    • 36048960109 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study
    • Fuchs CS, Marshall J, Mitchell E, et al. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol. 2007;25:4779-86.
    • (2007) J Clin Oncol , vol.25 , pp. 4779-4786
    • Fuchs, C.S.1    Marshall, J.2    Mitchell, E.3
  • 23
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Díaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008;26: 2013-9.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Díaz-Rubio, E.3
  • 24
    • 67650996205 scopus 로고    scopus 로고
    • Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer
    • Sobrero A, Ackland S, Clarke S, et al. Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer. Oncology. 2009;77: 113-9.
    • (2009) Oncology , vol.77 , pp. 113-119
    • Sobrero, A.1    Ackland, S.2    Clarke, S.3
  • 25
    • 84861382251 scopus 로고    scopus 로고
    • Intravenous aflibercept versus placebo in combination with irinotecan/5-FU (FOLFIRI) for second-line treatment of metastatic colorectal cancer (MCRC): Results of a multinational Phase III trial (EFC10262-VELOUR)
    • Van Cutsem E, Tabernero J, Lakomy R. Intravenous aflibercept versus placebo in combination with irinotecan/5-FU (FOLFIRI) for second-line treatment of metastatic colorectal cancer (MCRC): results of a multinational Phase III trial (EFC10262-VELOUR). Ann Oncol. 2011:22.
    • (2011) Ann Oncol , pp. 22
    • van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 26
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356:115-24.
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 27
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356:125-34.
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 28
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378-90.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 29
    • 23844548194 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo- controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/ 5-fluorouracil/ leucovorin and PTK787/ZK 222584 or placebo (CONFIRM- 1)
    • Abstr LBA3
    • Hecht JR, Trarbach T, Jaeger E. A randomized, double-blind, placebo- controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/ 5-fluorouracil/ leucovorin and PTK787/ZK 222584 or placebo (CONFIRM- 1). J Clin Oncol. 2005;23 Suppl 2:Abstr LBA3.
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL. 2
    • Hecht, J.R.1    Trarbach, T.2    Jaeger, E.3
  • 30
    • 36349019056 scopus 로고    scopus 로고
    • Final results of CONFIRM 2: A multinational, randomized, double-blind, phase III study in 2nd line patients (pts) with metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo
    • Kohne C, Bajetta E, Lin E. Final results of CONFIRM 2: A multinational, randomized, double-blind, phase III study in 2nd line patients (pts) with metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo. J Clin Oncol. 2007;25 Suppl 18S:4033.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18S , pp. 4033
    • Kohne, C.1    Bajetta, E.2    Lin, E.3
  • 31
    • 0032698140 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
    • Prewett M, Huber J, Li Y, et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res. 1999;59: 5209-18.
    • (1999) Cancer Res , vol.59 , pp. 5209-5218
    • Prewett, M.1    Huber, J.2    Li, Y.3
  • 32
    • 77954682879 scopus 로고    scopus 로고
    • Ramucirumab (IMC-1121B): A novel attack on angiogenesis
    • Spratlin JL, Mulder KE, Mackey JR. Ramucirumab (IMC-1121B): a novel attack on angiogenesis. Future Oncol. 2010;6:1085-94.
    • (2010) Future Oncol , vol.6 , pp. 1085-1094
    • Spratlin, J.L.1    Mulder, K.E.2    Mackey, J.R.3
  • 33
    • 77649213706 scopus 로고    scopus 로고
    • Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    • Spratlin JL, Cohen RB, Eadens M, et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol. 2010;28:780-7.
    • (2010) J Clin Oncol , vol.28 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3
  • 34
    • 70450175957 scopus 로고    scopus 로고
    • Targeting angiogenesis: Progress with anti-VEGF treatment with large molecules
    • Grothey A, Galanis E. Targeting angiogenesis: progress with anti-VEGF treatment with large molecules. Nat Rev Clin Oncol. 2009;6:507-18.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 507-518
    • Grothey, A.1    Galanis, E.2
  • 35
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med. 2001;7:987-9.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 36
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGFspecific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett CG, Boucher Y, di Tomaso E, et al. Direct evidence that the VEGFspecific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004;10:145-7.
    • (2004) Nat Med , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    di Tomaso, E.3
  • 37
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A. 2002;99:11393-8.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 38
    • 0037143739 scopus 로고    scopus 로고
    • Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
    • Kim ES, Serur A, Huang J, et al. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci U S A. 2002;99:11399-404.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11399-11404
    • Kim, E.S.1    Serur, A.2    Huang, J.3
  • 39
    • 74949119167 scopus 로고    scopus 로고
    • Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors
    • Lockhart AC, Rothenberg ML, Dupont J, et al. Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol. 2010;28:207-14.
    • (2010) J Clin Oncol , vol.28 , pp. 207-214
    • Lockhart, A.C.1    Rothenberg, M.L.2    Dupont, J.3
  • 40
    • 84861185993 scopus 로고    scopus 로고
    • A Phase I study of aflibercept, pemetrexed, and cisplatin in patients with advanced solid tumors
    • Abstr 2536
    • Townsley CA, Siu LL, Pedro-Salcedo MS. A Phase I study of aflibercept, pemetrexed, and cisplatin in patients with advanced solid tumors. J Clin Oncol. 2010;28 Suppl 15:Abstr 2536.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15
    • Townsley, C.A.1    Siu, L.L.2    Pedro-Salcedo, M.S.3
  • 41
    • 85051940688 scopus 로고    scopus 로고
    • Phase I study of aflibercept and temozolomide in newly diagnosed, high-grade glioma
    • Abstr 2043
    • De Groot JF, Cloughesy T, Lieberman FS. Phase I study of aflibercept and temozolomide in newly diagnosed, high-grade glioma. J Clin Oncol. 2011; Suppl 29:Abstr 2043.
    • (2011) J Clin Oncol , Issue.SUPPL. 29
    • de Groot, J.F.1    Cloughesy, T.2    Lieberman, F.S.3
  • 42
    • 67649262706 scopus 로고    scopus 로고
    • Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): A PMH phase II consortium trial
    • Abstr 4027
    • Tang P, Cohen SJ, Bjarnason GA. Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): a PMH phase II consortium trial. J Clin Oncol. 2008;Suppl 26:Abstr 4027.
    • (2008) J Clin Oncol , Issue.SUPPL. 26
    • Tang, P.1    Cohen, S.J.2    Bjarnason, G.A.3
  • 44
    • 33845656482 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors for bevacizumab- induced hypertension
    • Dincer M, Altundag K. Angiotensin-converting enzyme inhibitors for bevacizumab- induced hypertension. Ann Pharmacother. 2006;40:2278-9.
    • (2006) Ann Pharmacother , vol.40 , pp. 2278-2279
    • Dincer, M.1    Altundag, K.2
  • 45
    • 65549122619 scopus 로고    scopus 로고
    • Management of hypertension in angiogenesis inhibitor-treated patients
    • Izzedine H, Ederhy S, Goldwasser F, et al. Management of hypertension in angiogenesis inhibitor-treated patients. Ann Oncol. 2009;20:807-15.
    • (2009) Ann Oncol , vol.20 , pp. 807-815
    • Izzedine, H.1    Ederhy, S.2    Goldwasser, F.3
  • 47
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007;25:1539-44.
    • (2007) J Clin Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 48
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
    • Saltz LB, Lenz HJ, Kindler HL, et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol. 2007;25:4557-61.
    • (2007) J Clin Oncol , vol.25 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.J.2    Kindler, H.L.3
  • 49
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360:563-72.
    • (2009) N Engl J Med , vol.360 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 50
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27: 672-80.
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 51
    • 79551521053 scopus 로고    scopus 로고
    • Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08
    • Allegra CJ, Yothers G, O'Connell MJ, et al. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08. J Clin Oncol. 2011;29:11-6.
    • (2011) J Clin Oncol , vol.29 , pp. 11-16
    • Allegra, C.J.1    Yothers, G.2    O'Connell, M.J.3
  • 52
    • 84898691563 scopus 로고    scopus 로고
    • Investor update. Available from, Accessed September 28
    • Investor update. Available from: http://www.roche.com/investors/ir_update/inv-update-2010-09-18b.html. Accessed September 28, 2011.
    • (2011)
  • 54
    • 84857006733 scopus 로고    scopus 로고
    • A study of aflibercept versus placebo in patients with second-line docetaxel for locally advanced or Metastatic nonsmall- cell lung cancer (VITAL)
    • US National Institutes of Health, Available from, Accessed September 21
    • US National Institutes of Health. A study of aflibercept versus placebo in patients with second-line docetaxel for locally advanced or metastatic nonsmall- cell lung cancer (VITAL). Available from: http://clinicaltrials.gov/ct2/show/NCT00532155. Accessed September 21, 2011.
    • (2011)
  • 55
    • 74249092481 scopus 로고    scopus 로고
    • Biomarkers of angiogenesis and their role in the development of VEGF inhibitors
    • Murukesh N, Dive C, Jayson GC. Biomarkers of angiogenesis and their role in the development of VEGF inhibitors. Br J Cancer. 2010;102:8-18.
    • (2010) Br J Cancer , vol.102 , pp. 8-18
    • Murukesh, N.1    Dive, C.2    Jayson, G.C.3
  • 56
    • 84863045991 scopus 로고    scopus 로고
    • A randomized, phase IIb study of sunitinib plus 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) versus bevacizumab plus mFOLFOX6 as first-line treatment for metastatic colorectal cancer (mCRC): Interim results
    • Abstr 3532
    • Hecht JR, Yoshino T, Mitchell EP, et al. A randomized, phase IIb study of sunitinib plus 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) versus bevacizumab plus mFOLFOX6 as first-line treatment for metastatic colorectal cancer (mCRC): Interim results. J Clin Oncol. 2010;28 Suppl 15: Abstr 3532.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15
    • Hecht, J.R.1    Yoshino, T.2    Mitchell, E.P.3
  • 57
    • 84863017984 scopus 로고    scopus 로고
    • SUNCAP, a phase II study with sunitinib and capecitabine in patients with metastatic colorectal cancer (MCRC) refractory to previous treatment with 5FU/irinotecan/oxaliplatin
    • Abstr 545
    • Samson B, Latreille J, Nguyen NT, Sperlich C, Berbiche D, Tournigand C. SUNCAP, a phase II study with sunitinib and capecitabine in patients with metastatic colorectal cancer (MCRC) refractory to previous treatment with 5FU/irinotecan/oxaliplatin. J Clin Oncol. 2011;29 Suppl 4:Abstr 545.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 4
    • Samson, B.1    Latreille, J.2    Nguyen, N.T.3    Sperlich, C.4    Berbiche, D.5    Tournigand, C.6
  • 58
    • 84863071022 scopus 로고    scopus 로고
    • Final results of a multicenter phase II trial assessing sorafenib (S) in combination with irinotecan (i) as second- or later-line treatment in metastatic colorectal cancer (mCRC) patients (pts) with KRAS-mutated tumors (mt; NEXIRI)
    • Abstr e14002
    • Ychou M, Bouche O, Thézenas S, et al. Final results of a multicenter phase II trial assessing sorafenib (S) in combination with irinotecan (i) as second- or later-line treatment in metastatic colorectal cancer (mCRC) patients (pts) with KRAS-mutated tumors (mt; NEXIRI). J Clin Oncol. 2011;29 Suppl: Abstr e14002.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Ychou, M.1    Bouche, O.2    Thézenas, S.3
  • 59
    • 77953674924 scopus 로고    scopus 로고
    • A phase I dose escalation (DE) and pharmacokinetics (PK) study of intravenous aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in patients with advanced solid tumors (STs)
    • Abstr 3557
    • Rixe O, Verslype C, Khayat D, et al. A phase I dose escalation (DE) and pharmacokinetics (PK) study of intravenous aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in patients with advanced solid tumors (STs). J Clin Oncol. 2008;26 Suppl:Abstr 3557.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Rixe, O.1    Verslype, C.2    Khayat, D.3
  • 60
    • 84898692461 scopus 로고    scopus 로고
    • Aflibercept compared to placebo in term of eficacyin patients treatedwith gemcitabine for metastaticpancreatic cancer (VANILLA)
    • US National Institutes of Health, Available from, Accessed September 21
    • US National Institutes of Health. Aflibercept compared to placebo in term of eficacyin patients treatedwith gemcitabine for metastaticpancreatic cancer (VANILLA). Available from: http://www.clinicaltrials.gov/ct2/show/NCT00574275. Accessed September 21, 2011.
    • (2011)


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