SCOPUS 정보 검색 플랫폼

Volumn 18, Issue 30, 2012, Pages 9246-9257

From lin-benzoguanines to lin-benzohypoxanthines as ligands for zymomonas mobilis tRNA-guanine transglycosylase: Replacement of protein-ligand hydrogen bonding by importing water clusters

(11) Barandun, Luzi Jakob a Immekus, Florian b Kohler, Philipp C a Tonazzi, Sandro a Wagner, Björn c Wendelspiess, Severin c Ritschel, Tina b,d Heine, Andreas b Kansy, Manfred c Klebe, Gerhard b Diederich, François a

a ETH ZURICH (Switzerland)

b PHILIPPS UNIVERSITY MARBURG (Germany)

c F HOFFMANN LA ROCHE LTD (Switzerland)

d RADBOUD UNIVERSITY MEDICAL CENTER (Netherlands)

Author keywords

drug design; hydrogen bonds; molecular recognition; shigellosis; water clusters

Indexed keywords

AS-LIGANDS; BINDING AFFINITIES; BINDING MODES; BINDING POCKETS; CONFORMATIONAL SHIFTS; CYTOTOXIC; DRUG DESIGN; ENTEROHEMORRHAGIC ESCHERICHIA COLI; ENZYME ACTIVE SITES; FOOD-BORNE ILLNESS; INHIBITION CONSTANTS; MOLECULAR RECOGNITION PROPERTIES; POTENTIAL TARGETS; PROTEIN-LIGAND INTERACTIONS; ROLE OF WATER; SHIGA TOXIN; SHIGELLA FLEXNERI; SHIGELLOSIS; SIDE-CHAINS; STRUCTURE-BASED DRUG DESIGN; WATER CLUSTER; WATER MOLECULE; X-RAY COCRYSTAL STRUCTURE; ZYMOMONAS MOBILIS;

BINDING ENERGY; ENZYMES; ESCHERICHIA COLI; LIGANDS; MOLECULAR RECOGNITION; POSITIVE IONS;

HYDROGEN BONDS;

DRUG DERIVATIVE; GLYCOSYLTRANSFERASE; GUANINE; HYPOXANTHINE; LIGAND; QUEUINE TRNA RIBOSYLTRANSFERASE; QUEUINE TRNA-RIBOSYLTRANSFERASE; WATER;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HYDROGEN BOND; PROTEIN BINDING; SHIGELLA FLEXNERI; SHIGELLOSIS; X RAY CRYSTALLOGRAPHY; ZYMOMONAS;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DYSENTERY, BACILLARY; GUANINE; HYDROGEN BONDING; HYPOXANTHINE; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PENTOSYLTRANSFERASES; PROTEIN BINDING; SHIGELLA FLEXNERI; WATER; ZYMOMONAS;

EID: 84863922705 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.201200809 Document Type: Article

Times cited : (18)

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