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Journal of Medicinal Chemistry

Volumn 43, Issue 26, 2000, Pages 5037-5043

Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors

(8) Rotella, D P a Sun, Z a Zhu, Y a Krupinski, J a Pongrac, R a Seliger, L a Normandin, D a Macor, J E a

a BRISTOL MYERS SQUIBB (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N 3 BENZYLIMIDAZOQUINAZOLINONE SULFONAMIDE DERIVATIVE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; PYRAZOLOPYRIMIDINE DERIVATIVE; SILDENAFIL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DOG; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RABBIT; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; CATTLE; DOGS; DRUG EVALUATION, PRECLINICAL; HUMANS; MALE; MUSCLE, SMOOTH; MUSCLES; PENIS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; QUINAZOLINES; RABBITS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034727872 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm000336j Document Type: Article

Times cited : (35)

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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.