A new target for shigellosis: Rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase

Journal of Molecular Biology

Volumn 306, Issue 3, 2001, Pages 455-467

  Grädler, Ulrich ^a   Gerber, Hans Dieter ^a   Goodenough Lashua, DeeAnne M ^b   Garcia, George A ^b   Ficner, Ralf ^a   Reuter, Klaus ^a   Stubbs, Milton T ^a   Klebe, Gerhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Crystal structure; LUDI; Modified tRNA nucleoside; Rational drug design; Shigellosis

Indexed keywords

3,5 DIAMINOPHTHALHYDRAZIDE; 4 AMINOPHTHALHYDRAZIDE; 5 AMINO 3 (1H [1,2,4]TRIAZOL 3 YLSULFANYL)PHTHALHYDRAZIDE; 5 AMINO 3 (5 AMINO 1H [1,2,4]TRIAZOL 3 YLSULFANYL)PHTHALHYDRAZIDE; GLYCOSYLTRANSFERASE INHIBITOR; GUANINE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUEUINE; TRANSFER RNA; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTICODON; ARTICLE; COMPUTER PROGRAM; CRYSTAL STRUCTURE; DRUG DESIGN; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; SHIGELLA FLEXNERI; SHIGELLOSIS; X RAY CRYSTALLOGRAPHY; ZYMOMONAS MOBILIS;

BACTERIA (MICROORGANISMS); SHIGELLA FLEXNERI; ZYMOMONAS MOBILIS;

EID: 0035936686     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4256     Document Type: Article

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